Results 31 to 40 of about 25,277 (207)

Very important pharmacogene summary for VDR [PDF]

Pharmacogenetics and Genomics, 2012
The vitamin D receptor (VDR) binds the active form of vitamin D (1,25-dihydroxyvitamin D3). It belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. The gene was cloned by Baker and colleagues in 1988 and maps to chromosome 12q13.11 [1].
Poon, Audrey H., Gong, Li, Brasch-Andersen, Charlotte, Litonjua, Augusto A., Raby, Benjamin, Hamid, Qutayba, Laprise, Catherine, Weiss, Scott, Altman, Russ B., Klein, Teri E.   +9 more
openaire   +4 more sources

Difference and similarity of DNA sequence recognized by VDR homodimer and VDR/RXR heterodimer

Nucleic Acids Research, 1994
Nuclear receptors for the thyroid hormone and vitamin A and D cooperate with the retinoid X receptor (RXR) in activating the transcription. Although the hormone response elements for these receptors have been proposed in which spacing of the direct repeated motifs determine the specificity (so called 3-4-5 rule), vitamin D response elements (VDREs) in ...
J, Nishikawa, M, Kitaura, M, Matsumoto, M, Imagawa, T, Nishihara   +4 more
openaire   +3 more sources

Association of vitamin D receptor gene fok1 polymorphism with bone health in Pakistani population

Journal of Biochemical and Clinical Genetics, 2020
Background: Osteoporosis is the bone disease characterized by demineralization of the bone. One of the most important genetic factors responsible for the osteoporosis is the vitamin D receptor (VDR) gene polymorphism.
Najam Farooq, Anwar Ullah, Abida Arshad, Navida Riaz, Jabar Zaman Khan, Sobia Tabassum, Muhammad Arshad Malik   +6 more
doaj   +1 more source

A simple and sensitive method to detect vitamin D receptor expression in various disease models using stool samples

Genes and Diseases, 2021
Vitamin D receptor (VDR) executes the main biological functions of its ligand vitamin D. VDR/vitamin D plays critical roles in regulating host immunity, maintaining barrier functions, and shaping gut microbiome.
Yong-guo Zhang, Yinglin Xia, Jun Sun
doaj   +1 more source

The Anti-Sepsis Effect of Isocorydine Screened from Guizhou Ethnic Medicine is Closely Related to Upregulation of Vitamin D Receptor Expression and Inhibition of NFκB p65 Translocation into the Nucleus

Journal of Inflammation Research, 2022
Jing Luo,1 Nuoyan Wang,1 Ling Hua,1 Fei Deng,1 Dan Liu,1 Jun Zhou,1 Yue Yuan,1 Fumin Ouyang,1 Xuemin Chen,1 Shujuan Long,1 Yasi Huang,1 Zhanxing Hu,2,3 Hong Zhou1 1Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International ...
Luo J, Wang N, Hua L, Deng F, Liu D, Zhou J, Yuan Y, Ouyang F, Chen X, Long S, Huang Y, Hu Z, Zhou H   +12 more
doaj  

Vitamin D Receptor Activation Targets ROS-Mediated Crosstalk Between Autophagy and Apoptosis in Hepatocytes in Cholestasic MiceSummary

Cellular and Molecular Gastroenterology and Hepatology, 2023
Background & Aims: Observational epidemiologic studies have associated vitamin D deficiency with cholestasis. We reported previously that activation of the vitamin D/vitamin D receptor (VDR) axis in cholangiocytes mitigates cholestatic liver injury ...
Zhijian Zheng, Jing Xie, Liman Ma, Zhiqing Hao, Weiwei Zhang, Lihua Li   +5 more
doaj   +1 more source

Quercetin Directly Interacts with Vitamin D Receptor (VDR): Structural Implication of VDR Activation by Quercetin [PDF]

Biomolecules & Therapeutics, 2016
The vitamin D receptor (VDR) is a member of the nuclear receptor (NR) superfamily. The VDR binds to active vitamin D3 metabolites, which stimulates downstream transduction signaling involved in various physiological activities such as calcium homeostasis, bone mineralization, and cell differentiation.
Lee, Ki-Young, Choi, Hye-Seung, Choi, Ho-Sung, Chung, Ka Young, Lee, Bong-Jin, Maeng, Han-Joo, Seo, Min-Duk   +6 more
openaire   +2 more sources

Stress-induced c-Jun-dependent Vitamin D Receptor (VDR) Activation Dissects the Non-classical VDR Pathway from the Classical VDR Activity [PDF]

Journal of Biological Chemistry, 2007
Vitamin D receptor (VDR) is a ligand-dependent transcription factor that mediates vitamin D(3)-induced gene expression. Our previous work has established that stress MAPK signaling stimulates VDR expression (Qi, X., Pramank, R., Wang, J., Schultz, R. M., Maitra, R. K., Han, J., DeLuca, H. F., and Chen, G. (2002) J. Biol. Chem. 277, 25884-25892) and VDR
Qing-Ping, Li, Xiaomei, Qi, Rocky, Pramanik, Nicole M, Pohl, Mathew, Loesch, Guan, Chen   +5 more
openaire   +2 more sources

Vitamin D Receptor (VDR) mRNA and VDR Protein Levels in Relation to Vitamin D Status, Insulin Secretory Capacity, and VDR Genotype in Bangladeshi Asians [PDF]

Diabetes, 2002
Associations have been reported between vitamin D receptor (VDR) gene polymorphisms, type 1 diabetes, insulin secretion, and the insulin resistance syndrome. As VDR polymorphisms have no known functional significance, these findings may implicate a variant of the VDR gene or a locus in linkage disequilibrium with the VDR.
Babatunji-William, Ogunkolade, Barbara J, Boucher, Jean M, Prahl, Stephen A, Bustin, Jacky M, Burrin, Kate, Noonan, Bernard V, North, Nassima, Mannan, Michael F, McDermott, Hector F, DeLuca, Graham A, Hitman   +10 more
openaire   +2 more sources

Ein photoschaltbares Vitamin‐D‐Mimetikum mit agonistischer und antagonistischer Aktivität ermöglicht bidirektionale optische Kontrolle von VDR

Angewandte Chemie, EarlyView.
Vitamin D entfaltet über die Aktivierung des ligandenabhängigen Transkriptionsfaktors Vitamin‐D‐Rezeptor (VDR) komplexe und zellspezifische biologische Wirkungen in verschiedenen Geweben. Das photoschaltbare Vitamin‐D‐Mimetikum 10 wechselt durch Belichtung zwischen VDR‐Antagonisten‐ (E) und Agonisten‐Aktivität (Z) und bietet eine bislang einzigartige ...
Xiu Ge, Sabine Willems, Francesco Melfi, Tufan Mukhopadhyay, Johannes Morstein, Jordan Artzy, Loris Knümann, Giorgia Sbriccoli, Jörg Pabel, Julian A. Marschner, Dirk Trauner, Daniel Merk   +11 more
wiley   +1 more source