Results 51 to 60 of about 12,305 (169)

Vitamin D Receptor (VDR) Regulation of Voltage-Gated Chloride Channels by Ligands Preferring a VDR-Alternative Pocket (VDR-AP)

, 2011
We have postulated that the vitamin D receptor (VDR) contains two overlapping ligand binding sites, a genomic pocket and an alternative pocket (AP), that mediate regulation of gene transcription and rapid responses, respectively.
Antonio Barrientos-Duran, Anthony W. Norman, Danusa Menegaz, Ning Chen, Helen L. Henry, Mathew T. Mizwicki   +5 more
core   +1 more source

Vitamin D receptor ChIP-seq in primary CD4+ cells: relationship to serum 25-hydroxyvitamin D levels and autoimmune disease. [PDF]

, 2013
BACKGROUND: Vitamin D insufficiency has been implicated in autoimmunity. ChIP-seq experiments using immune cell lines have shown that vitamin D receptor (VDR) binding sites are enriched near regions of the genome associated with autoimmune diseases.
Heather Hanwell, Adam E Handel, Giulio Disanto, Gavin Giovannoni, Sandve, GK, Berlanga-Taylor, AJ, Geir K Sandve, Finn Drabløs, Disanto, Giulio, Drabløs, F, Handel, Adam, Giuseppe Gallone, George C Ebers, Ramagopalan, Sreeram V, Ebers, George, Drabløs, Finn, Drablos, F, Hanwell, Heather EC, Antonio J Berlanga-Taylor, Handel, Adam E, Sandve, Geir Kjetil, Ebers, Georg C, Ramagopalan, SV, Hanwell, H, Handel, AE, Price, RN, Sreeram V Ramagopalan, Gallone, G, Ebers, GC, Gallone, Anna, Giovannoni, Gavin, Berlanga-Taylor, Antonio, Giovannoni, G, Price, Richard, Disanto, G   +34 more
core   +2 more sources

Characterization and Analysis of PHEX Variants in Patients With Hypophosphatemia in Argentina

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Confirming the underlying molecular etiology of hereditary hypophosphatemia (HH) to provide recurrence risk counseling is highly important. Our aims were to describe the detected variants and their distribution across Argentina and to contrast them with published data.
Silvia Ávila, Sara Fernández, Maximiliano Zeballos, María Georgina Poggio   +3 more
wiley   +1 more source

Reframing the Gut–Brain Axis: The Gut Wall as a Neural Immune Interface in Multiple Sclerosis and Autoimmune Neurological Diseases

Annals of Neurology, EarlyView.
Gut wall physiology in multiple sclerosis (MS) and autoimmune neurologic diseases remains underexplored but may span gut barrier dysfunction, enteric glial targeting, mucosal immune dysregulation, and autoimmune targets within the enteric nervous system (ENS).
Federico Montini, Sean J. Pittock, Laura Cacciaguerra, Howard L. Weiner, Luke A. Schwerdtfeger   +4 more
wiley   +1 more source

Assessment of VDR-RXR interactions.

, 2015
(A) Analysis of overexpressed RXR on VDR transactivation and (B) VDR-RXR heterodimerization in response to 1, 25D3. (A) HepG2 cells were transiently transfected with pSG5-VDR, the XREM-Luc reporter, and the pRL-CMV internal luciferase control as ...
David M. Reif (218469), Seth W. Kullman (292134), Guozhu Zhang (719744), Mary Beth Hawkins (211225), Erin M. Kollitz (719743), G. Kerr Whitfield (719745)   +5 more
core   +1 more source

Vitamin D receptor prevents tumour development by regulating the Wnt/β-catenin signalling pathway in human colorectal cancer

BMC Cancer, 2023
Background Colorectal cancer (CRC) is a common disease threatening human lives worldwide, and vitamin D receptor (VDR) contributes protective roles in this disease.
Jie Yu, Qi Sun, Yi Hui, Jinping Xu, Pancheng Shi, Yu Chen, Yunzhao Chen   +6 more
doaj   +1 more source

Characterization of Rickets Type II Model Rats to Reveal Functions of Vitamin D and Vitamin D Receptor

Biomolecules, 2023
Vitamin D has been known to exert a wide range of physiological effects, including calcemic, osteogenic, anticancer, and immune responses. We previously generated genetically modified (GM) rats and performed a comparative analysis of their physiological ...
Yuichiro Iwai, Ayano Iijima, Satoko Kise, Chika Nagao, Yuto Senda, Kana Yabu, Hiroki Mano, Miyu Nishikawa, Shinichi Ikushiro, Kaori Yasuda, Toshiyuki Sakaki   +10 more
doaj   +1 more source

Vitamin D3: research breakthroughs and therapeutic use

Annals of Mechnikov's Institute, 2019
Vitamin D3 (cholecalciferol), the natural form of vitamin D, is produced in the skin from 7-dehydrocholesterol. The synthesis of vitamin D in the skin is the most important source of vitamin D.
М Pohorila, A Martynov, E Romanova, N Іgumnova, Т Sidorenko, V Yukhimenko, O Shcherbak   +6 more
doaj  

Population-genetic research of the VDR gene polymorphism

Фундаментальная и клиническая медицина, 2019
Aim. To explore the prevalence of alleles and genotypes in rsl544410 polymorphism within the VDR gene in the population of Kemerovo Region.Materials and Methods. Genotyping was performed in 232 residents of Kemerovo region (125 men and 107 women, average
A. N. Volkov, E. V. Tsurkan
doaj   +1 more source

Immunohistochemical expression of vitamin D receptor and forkhead box P3 in classic Hodgkin lymphoma: correlation with clinical and pathologic findings

BMC Cancer, 2020
Background Expression of forkhead box P3 (FOXP3), a key regulator of T-cell function, in the tumor immune microenvironment is related to survival in classic Hodgkin lymphoma (CHL). Vitamin D receptor (VDR), a transcription factor agonists have been shown
Gaurav K. Gupta, Tanupriya Agrawal, Monika Pilichowska   +2 more
doaj   +1 more source