Results 41 to 50 of about 12,305 (169)

Western blotting of VDR in the wild-type and VDR-KO HCT116 cells.

, 2023
Lack of VDR protein in the VDR KO HCT116 cells used in this study was confirmed by Western blotting. The left panel showed lack of VDR protein expression in the KO cells with the internal control of β-actin protein expression. (TIF)
Yoshiaki Kanemoto (17628166), Shigeaki Kato (294800), Rino Tsutsumi (17628172), Miho Iwaki (17628163), Tomohiro Kurokawa (15031457), Kazuo Nagasawa (1685587), Koki Nojiri (17628169), Takahiro Sawada (184183)   +7 more
core   +1 more source

VDR

, 2015
In this work, we propose VDR, a routing scheme based on virtual domains -- domains that are not bound to physical routers -- to exploit the benefits of aggregation and hashing while overcoming their disadvantages.
Xiaoming Fu, Fu, Xiaoming, Jiachen Chen, Li, Jie, Chen, Jiachen, Wang, Xingwei, Jie Li, Mayutan Arumaithurai, Xingwei Wang, Arumaithurai, Mayutan   +9 more
core   +1 more source

Overexpression of the vitamin D receptor (VDR) induces skeletal muscle hypertrophy [PDF]

, 2020
ObjectiveThe Vitamin D receptor (VDR) has been positively associated with skeletal muscle mass, function and regeneration. Mechanistic studies have focused upon loss of the receptor, with in vivo whole-body knockout models demonstrating reduced myofiber ...
Atherton, Philip J.,, Garcia, Amadeo Mu�oz, Szewczyk, Nathaniel J., Gallagher, Iain J.,, Smith, Ken,, Atherton, Philip J., Brook, Matthew S., Andersen, Ditte, Garcia, Amadeo Muñoz, Nakhuda, Asif,, Wilkinson, Daniel J., Cleasby, Mark E, Atherton, Philip J, Garcia, Amadeo Munoz,, Cleasby, Mark E., Andersen, Ditte,, Philp, Andrew,, Gallagher, Iain James, Brook, Matthew S.,, Deane, Colleen S.,, Kadi, Fawzi,, Gallagher, Iain J, Deane, Colleen S, Gallagher, Iain J., Wilkinson, Daniel J.,, Szewczyk, Nathaniel J.,, Cleasby, Mark E.,, Szewczyk, Nathaniel, Bass, Joseph J., Smith, Ken, Philp, Andrew, Bass, Joseph J.,, Tarum, Janelle, Brook, Mathew S., Szewczyk, Nathaniel J, Phillips, Bethan E.,, Deane, Colleen S., Wilkinson, Daniel J, Tarum, Janelle,, Phillips, Bethan E, Brook, Matthew S, Bass, Joseph J, Phillips, Bethan E., Kadi, Fawzi, Nakhuda, Asif   +44 more
core   +1 more source

siRNA-mediated knockdown of VDR.

, 2013
A) Comparison of VDR mRNA levels. VDR siRNA treatment suppressed VDR mRNA expression. After 12 hours of vitamin D treatment (1×10−7 M) applied to VDR-silenced neurons, VDR mRNA levels increased.
Erdinç Dursun (355265), Selma Yilmazer (355267), Duygu Gezen-Ak (355264)   +2 more
core   +1 more source

Charting Endocrine Progenitors Across Species and Organs

Advanced Science, EarlyView.
Endocrine progenitors give rise to the hormone‐producing cells of the pancreas and intestine. Using single‐cell multiomics and proteomics, this study compares these progenitors across species, systems, and organs, mapping the conserved and species‐specific gene regulatory networks that guide their formation.
Changying Jing, Michael Sterr, Özüm Sehnaz Caliskan, Lama Saber, Nicole Katarina Rogers, Samuel Ogden, Kei Kozawa, Christos Karampelias, Jessica Jaki, Aimée Bastidas‐Ponce, Falk Janos Farkas, Oliver Czarnecki, Osvaldo Rodrigues Pereira, Perla Cota, Valerie Vandenbempt, Diego Balboa, Anika Böttcher, Natalie Krahmer, Mohammad Lotfollahi, Julie B. Sneddon, Heiko Lickert, Mostafa Bakhti   +21 more
wiley   +1 more source

Gut Microbiota‐Isoallolithocholic Acid Crosstalk Promotes Calcium Oxalate Kidney Stone Formation via PARP1‐Mediated Parthanatos

Advanced Science, EarlyView.
ABSTRACT Bile acids have been implicated in calcium oxalate (CaOx) nephrolithiasis. Here, we employ multi‐omics approaches to identify isoallolithocholic acid (isoalloLCA) as the key bile acid elevated in the feces, serum, kidney, and urine of CaOx rats, confirmed by spatial metabolomics.
Zijian Zhou, Ruixi Yu, Xuan Zhou, Feng Shi, Zeyu Lin, Peng Gao, Lujia Wang, Ninghan Feng, Zhong Wu, Dawei Wang   +9 more
wiley   +1 more source

Efeito de ligantes dos receptores nucleares PXR e VDR na expressão de genes de biotransformação no fígado e intestino de peixes Danio rerio [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Bioquímica, Florianópolis, 2010O receptor de Vitamina D (VDR) e o receptor Pregnano X (PXR) são receptores nucleares e agem como ...
Siebert, Marília Nardelli
core  

A Unified Hierarchical Multiscale Fusion Framework for Drug–Target Affinity Prediction: From Benchmark Performance to Nanomolar Inhibitor Discovery

Advanced Science, EarlyView.
A multimodal fusion framework integrating sequence, atomic, and fragment representations captures drug–target interactions across multiple scales. The model delivers strong predictive performance and enables efficient virtual screening. Applied to hematopoietic progenitor kinase 1 (HPK1), it identifies structurally diverse inhibitors with nanomolar ...
Shuo Liu, Xiang Zhang, Haixia Feng, Yuquan Li, Xiaoqing Gong, Yong Liang, Xiaojun Yao, Huanxiang Liu   +7 more
wiley   +1 more source

Integrated O2 and H2 Gas Therapy via Microneedle‐Assisted Photocatalytic Water Splitting for Accelerating Diabetic Full‐Thickness Skin Wound Healing

Advanced Science, EarlyView.
A concept of integrated O2 and H2 gas therapy is achieved using a gas‐producing material. PMP nanoparticles, fabricated from platinum, MIL‐101(Fe)‐NH2, and phosphotungstic acid, are integrated into bilayer gelatin methacryloyl microneedles for transdermal delivery. These microneedles enable integrated O2 and H2 gas therapy and promote wound healing via
Zesheng Chen, Yanchao Yu, Xingyuan Xiao, Wenwen Cheng, Ye Yang, Zhengyao Zhang, Wang Wang, Zhijun Zhou, Weikang Hu, Xiaolong Wang, Bing Li, Kwang Leong Choy, Yun Chen, Zijian Wang   +13 more
wiley   +1 more source

T‐Cell Remodeling in Renal Fibrosis: From Acute Injury to Chronic Kidney Disease

Advanced Science, EarlyView.
This Review presents renal fibrosis as a sequence of overlapping T‐cell programs, from chemokine‐guided recruitment and metabolic activation to maladaptive polarization, tertiary lymphoid structure formation, tissue residency, exhaustion, and senescence.
Qianhui Li, Junting Guan, Yifan Song, Hongxia Yang, Guangtao Li, Xiaodong Zhao, Jiaxin Liu, Bin Liu, Yang Tan, Honglan Zhou, Yang‐He Zhang, Yishu Wang   +11 more
wiley   +1 more source