Results 11 to 20 of about 25,428 (209)

Vitamin D Receptor (VDR) Regulation of Voltage-Gated Chloride Channels by Ligands Preferring a VDR-Alternative Pocket (VDR-AP) [PDF]

Molecular Endocrinology, 2011
We have postulated that the vitamin D receptor (VDR) contains two overlapping ligand binding sites, a genomic pocket and an alternative pocket (AP), that mediate regulation of gene transcription and rapid responses, respectively. Flexible VDR + ligand docking calculations predict that the major blood metabolite, 25(OH)-vitamin D3 (25D3), and curcumin ...
Danusa, Menegaz, Mathew T, Mizwicki, Antonio, Barrientos-Duran, Ning, Chen, Helen L, Henry, Anthony W, Norman   +5 more
openaire   +2 more sources

Enhancement of VDR-Mediated Transcription by Phosphorylation: Correlation with Increased Interaction Between the VDR and DRIP205, a Subunit of the VDR-Interacting Protein Coactivator Complex [PDF]

Molecular Endocrinology, 2002
When UMR-106 osteoblastic cells, LLCPK1 kidney cells, and VDR transfected COS-7 cells were transfected with the rat 24-hydroxylase [24(OH)ase] promoter (-1,367/+74) or the mouse osteopontin (OPN) promoter (-777/+79), we found that the response to 1,25dihydroxyvitamin D(3) [1,25-(OH)(2)D(3)] could be significantly enhanced 2- to 5-fold by the protein ...
Frank, Barletta, Leonard P, Freedman, Sylvia, Christakos   +2 more
openaire   +3 more sources

Gene variants and haplotypes of Vitamin D biosynthesis, transport, and function in preeclampsia

Hypertension in Pregnancy, 2021
Objective: To find whether the gene variants and haplotypes of cytochrome (CYP) 27B1 (1α-hydroxylase), group-specific component (GC) that is a vitamin D binding protein, vitamin D receptor (VDR), peroxisome proliferator-activated receptor γ (PPARγ) and ...
Zahra Ghorbani, Mohammad Shakiba, Negin Rezavand, Ziba Rahimi, Asad Vaisi-Raygani, Zohreh Rahimi, Ebrahim Shakiba   +6 more
doaj   +1 more source

VDR

Proceedings of the 2nd ACM Conference on Information-Centric Networking, 2015
In this work, we propose VDR, a routing scheme based on virtual domains -- domains that are not bound to physical routers -- to exploit the benefits of aggregation and hashing while overcoming their disadvantages. VDR addresses the FIB scalability issue in CCN by facilitating aggregation without compromising on the advantages of CCN such as ease of ...
Jie Li 0008, Jiachen Chen, Mayutan Arumaithurai, Xingwei Wang 0001, Xiaoming Fu 0001   +4 more
openaire   +3 more sources

The role of vitamin D in seasonal acute respiratory viral infections and COVID-19

Терапевтический архив, 2020
A link between vitamin D deficiency and susceptibility to infectious diseases was suggested over a hundred years ago. Epidemiological studies show a strong association between seasonal fluctuations in vitamin D levels and the incidence of various ...
E. A. Pigarova, A. A. Povalyaeva, L. K. Dzeranova, L. Y. Rozhinskaya, N. G. Mokrysheva   +4 more
doaj   +1 more source

Association of Single Nucleotide Polymorphisms in the VDR and CYP27B1 Genes with Risk of Developing Vitamin D3 Deficiency

Journal of Pure and Applied Microbiology, 2021
This study was carried out to investigate the relationship between common variants in two vitamin D pathway genes (VDR and CYP27B1) and vitamin D3 serum levels.
Hormoz Selahvarzi, Milad Kamdideh, Mehrnoosh Vahabi, Ali Dezhgir, Massoud Houshmand, Soha Sadeghi   +5 more
doaj   +1 more source

Nephrolithiasis in primary hyperparathyroidism: a contemporary look

Ожирение и метаболизм, 2014
Primary hyperparathyroidism (PHPT) has attracted a growing attention of medical doctors of different specialties in the last few years. The ability to predict the risk of the development of visceral manifestations (nephrolithiasis, nephrocalcinosis ...

doaj   +1 more source

1,25-Dihydroxycholecalciferol Improved the Growth Performance and Upregulated the Calcium Transporter Gene Expression Levels in the Small Intestine of Broiler Chickens

The Journal of Poultry Science, 2022
1,25-Dihydroxycholecalciferol (1,25-(OH)2-D3) is the final active product of vitamin D. This study aimed to investigate the effects of 1,25-(OH)2-D3 on growth performance, bone development, and calcium (Ca) transporter gene expression levels in the ...
Lihua Wu, Xiaona Wang, Xianliang Lv, Lei He, Hongxia Qu, Chuanxin Shi, Liao Zhang, Jinliang Zhang, Zhixiang Wang, Jincheng Han   +9 more
doaj   +1 more source

VDR and gemini ligands

Oncotarget, 2015
The active form of vitamin D, 1α,25-dihydroxyvitamin D3 [1,25(OH)2D3; calcitriol], plays a key role in mineral and bone homeostasis, and exerts potent anti-inflammatory and anti-proliferative activities [1]. It is thus a potential pharmacological agent to treat various diseases, including autoimmune disorders, infections and cancer [1].
Laverny, Gilles, Metzger, Daniel
openaire   +2 more sources

Presence of a Truncated Form of the Vitamin D Receptor (VDR) in a Strain of VDR-Knockout Mice [PDF]

Endocrinology, 2005
As part of our studies on the membrane-initiated actions of 1α,25-dihydroxyvitamin D3 [1α,25(OH)2D3] and its localization in caveolae membrane fractions, we used a vitamin D receptor (VDR)-knockout (KO) mouse model to study the binding of [3H]-1α,25(OH)2D3 in the presumed absence of the VDR.
Craig M, Bula, Johanna, Huhtakangas, Christopher, Olivera, June E, Bishop, Anthony W, Norman, Helen L, Henry   +5 more
openaire   +2 more sources