Results 21 to 30 of about 59,545 (218)

Vitamin D receptor gene polymorphisms and prognosis of breast cancer among African-American and Hispanic women. [PDF]

, 2013
BackgroundVitamin D plays a role in cancer development and acts through the vitamin D receptor (VDR). Although African-Americans have the lowest levels of serum vitamin D, there is a dearth of information on VDR gene polymorphisms and breast cancer among
Chen, Zujian, Heber, David, Koeffler, H Phillip, Mishra, Dhruva K, Ong, May, Sarkissyan, Marianna, Sarkissyan, Suren, Shang, Xiying, Vadgama, Jaydutt V, Wu, Yanyuan   +9 more
core   +2 more sources

Quick-VDR: interactive view-dependent rendering of massive models [PDF]

IEEE Visualization 2004, 2004
We present a novel approach for interactive view-dependent rendering of massive models. Our algorithm combines view-dependent simplification, occlusion culling, and out-of-core rendering. We represent the model as a clustered hierarchy of progressive meshes (CHPM).
Sung-Eui Yoon, Brian Salomon, Russell Gayle, Dinesh Manocha   +3 more
openaire   +1 more source

Deletion of vitamin D receptor leads to premature emphysema/COPD by increased matrix metalloproteinases and lymphoid aggregates formation [PDF]

, 2011
Deficiency of vitamin D is associated with accelerated decline in lung function. Vitamin D is a ligand for nuclear hormone vitamin D receptor (VDR), and upon binding it modulates various cellular functions.
Hwang, Jae-woong, Rahman, Irfan, Sun, Jun, Sundar, Isaac K, Wu, Shaoping   +4 more
core   +1 more source

Stress-induced c-Jun-dependent Vitamin D Receptor (VDR) Activation Dissects the Non-classical VDR Pathway from the Classical VDR Activity [PDF]

Journal of Biological Chemistry, 2007
Vitamin D receptor (VDR) is a ligand-dependent transcription factor that mediates vitamin D(3)-induced gene expression. Our previous work has established that stress MAPK signaling stimulates VDR expression (Qi, X., Pramank, R., Wang, J., Schultz, R. M., Maitra, R. K., Han, J., DeLuca, H. F., and Chen, G. (2002) J. Biol. Chem. 277, 25884-25892) and VDR
Qing-Ping, Li, Xiaomei, Qi, Rocky, Pramanik, Nicole M, Pohl, Mathew, Loesch, Guan, Chen   +5 more
openaire   +2 more sources

1,25-Dihydroxycholecalciferol Improved the Growth Performance and Upregulated the Calcium Transporter Gene Expression Levels in the Small Intestine of Broiler Chickens

The Journal of Poultry Science, 2022
1,25-Dihydroxycholecalciferol (1,25-(OH)2-D3) is the final active product of vitamin D. This study aimed to investigate the effects of 1,25-(OH)2-D3 on growth performance, bone development, and calcium (Ca) transporter gene expression levels in the ...
Lihua Wu, Xiaona Wang, Xianliang Lv, Lei He, Hongxia Qu, Chuanxin Shi, Liao Zhang, Jinliang Zhang, Zhixiang Wang, Jincheng Han   +9 more
doaj   +1 more source

The role of vitamin D receptor signaling in hair follicle health and alopecia: Current understanding and therapeutic implications. [PDF]

J Cell Commun Signal
The vitamin D receptor (VDR) regulates hair follicle biology through ligand‐dependent and ligand‐independent mechanisms by heterodimerizing with retinoid X receptor, recruiting coactivator complexes, and activating target genes including Wnt inhibitors, hair keratins, and cell cycle regulators.
Guan L, Yang F, Li M, Chen Y, Zhao Z, Li H, Luo D, Li Q, Chen Y.   +8 more
europepmc   +2 more sources

Molecular Static and Dynamic Analyses reveal Flaw in Murine Model used by US FDA to Detect Drug Carcinogenicity [PDF]

, 2007
The US FDA currently accepts carcinogenicity studies of pharmaceutical drugs based on murine models. In addition to 6 month studies with p53(+/-) and ras.H2 transgenic mice, lifetime studies (typically 2 years) in WT mice or rats are also considered as ...
Trevor Marshall
core   +2 more sources

Nephrolithiasis in primary hyperparathyroidism: a contemporary look

Ожирение и метаболизм, 2014
Primary hyperparathyroidism (PHPT) has attracted a growing attention of medical doctors of different specialties in the last few years. The ability to predict the risk of the development of visceral manifestations (nephrolithiasis, nephrocalcinosis ...

doaj   +1 more source

The Association between Vitamin D Receptor Expression and Prolonged Overall Survival in Breast Cancer. [PDF]

, 2012
Summary In this study, we analyzed vitamin D receptor (VDR) expression and survival in a breast cancer patient cohort of 82 breast cancer patients. Immunohistochemical analysis was possible in 91.5% of the patients (75/82). Staining was evaluated using
Berger U, Berger U, Boecker W, Conde I, Eisman JA, Frampton RJ, Freake HC, Gombart AF, Jeschke U, Mason BH, Mylonas I, Remmele W, Ulmann A, Zinser GM   +13 more
core   +2 more sources

Association of rs2476601 and rs1544410 with Onset of T1D in Youngsters of Lahore, Pakistan

Journal of Bioresource Management, 2016
The PTPN22 gene plays vital role in T1D onset by encoding Lymphoid-specific phosphatase (LYP) that lead to T-cell receptor-associated CsK kinase inactivation and preventing T-cell spontaneous activation by dephosphorylation.
Andleeb Batool, Maryam Mukhtar, Iram Qayyum, Romessa Shakeel   +3 more
doaj   +1 more source