Results 51 to 60 of about 2,059,233 (272)

Rickettsiosis in Denmark: A nation-wide survey

Ticks and Tick-Borne Diseases, 2023
Rickettsia helvetica has been reported at varying prevalences in Danish and other European Ixodes ricinus populations. Though apparently widespread and with reported cases of human infection, the significance of the bacteria as a threat to public health ...
Bo Bødker Jensen, Nanna Skaarup Andersen, Silke Wölfel, Ming Chen, Helene M. Paarup, Carsten Riis Olesen, Pierre Edouard Fournier, Per Moestrup Jensen, Sigurdur Skarphedinsson   +8 more
doaj   +1 more source

Modeling preferential attraction to infected hosts in vector-borne diseases

Frontiers in Public Health, 2023
Vector-borne infectious diseases cause more than 700,000 deaths a year and represent an increasing threat to public health worldwide. Strategies to mitigate the spread of vector-borne diseases can benefit from a thorough understanding of all mechanisms that contribute to viral propagation in human.
Ishwor Thapa, Dario Ghersi
openaire   +3 more sources

Emerging roles of non-coding RNAs in vector-borne infections [PDF]

Journal of Cell Science, 2020
ABSTRACT Non-coding RNAs (ncRNAs) are nucleotide sequences that are known to assume regulatory roles previously thought to be reserved for proteins. Their functions include the regulation of protein activity and localization and the organization of subcellular structures. Sequencing studies have now identified thousands of ncRNAs encoded
Chaima Bensaoud, Larissa Almeida Martins, Hajer Aounallah, Michael Hackenberg, Michail Kotsyfakis   +4 more
openaire   +2 more sources

Innate and Adaptive Immune Genes Associated with MERS-CoV Infection in Dromedaries

Cells, 2021
The recent SARS-CoV-2 pandemic has refocused attention to the betacoronaviruses, only eight years after the emergence of another zoonotic betacoronavirus, the Middle East respiratory syndrome coronavirus (MERS-CoV).
Sara Lado, Jean P. Elbers, Martin Plasil, Tom Loney, Pia Weidinger, Jeremy V. Camp, Jolanta Kolodziejek, Jan Futas, Dafalla A. Kannan, Pablo Orozco-terWengel, Petr Horin, Norbert Nowotny, Pamela A. Burger   +12 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Mathematical modeling in perspective of vector-borne viral infections: a review

Beni-Suef University Journal of Basic and Applied Sciences, 2022
AbstractBackgroundViral diseases are highly widespread infections caused by viruses. These viruses are passing from one human to other humans through a certain medium. The medium might be mosquito, animal, reservoir and food, etc. Here, the population of both human and mosquito vectors are important.Main body of the abstractThe main objectives are here
Ramakant Prasad, Surendra Kumar Sagar, Shama Parveen, Ravins Dohare   +3 more
openaire   +3 more sources

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Role of immune cell subsets in the establishment of vector‐borne infections [PDF]

European Journal of Immunology, 2012
Many of the pathogens responsible for diseases that result in both economic and global health burdens are transmitted by arthropod vectors in the course of a blood meal. In the past, these vectors were viewed mainly as simple delivery vehicles but the appreciation of the role that factors in the saliva of vectors play during pathogen transmission is ...
Wolfgang W, Leitner, Adriana, Costero-Saint Denis, Tonu, Wali   +2 more
openaire   +2 more sources