Results 61 to 70 of about 1,916,755 (267)

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Myogenic Fusogen‐Engineered Lipid Nanoparticles Enhance mRNA Delivery in Skeletal Muscle

Advanced Functional Materials, EarlyView.
This study reports a biomimetic strategy of engineering full‐length Myomaker, a muscle‐specific fusogen, into lipid nanoparticles (LNPs) to harness the native myoblast fusion capability for skeletal muscle mRNA delivery. The resulting Mymk‐LNPs enhance transfection in differentiating myocytes and enable Cre‐mediated reporter activation in injured ...
Fangyu Zhang, Zhisheng Xu, Yaou Duan, Yehui Sun, Shiying Wu, Tao Long, Mateusz Durbacz, Li Zhang, Yufen Xiao, Yu‐Chung Pien, Erick D. Guerrero, Zeru Tian, Xu Wang, Pratima Basak, Sumanta Chatterjee, Ning Liu, Xiaochun Li, Eric N. Olson, Daniel J. Siegwart   +18 more
wiley   +1 more source

Seroprevalence and current infections of canine vector-borne diseases in Nicaragua [PDF]

Parasites & Vectors, 2018
Vector-borne diseases constitute a major problem for veterinary and public health, especially in tropical regions like Central America. Domestic dogs may be infected with several vector-borne pathogens of zoonotic relevance, which may also severely compromise canine health.To assess the prevalence of canine vector-borne diseases in Nicaragua, 329 dogs ...
Springer, Andrea, Montenegro, Víctor M., Schicht, Sabine, Pantchev, Nikola, Strube, Christina   +4 more
openaire   +5 more sources

An Epigenetic Fate Converter Based on Nuclei‐Targeting Lipid Nanoparticles Drives Neuronal Programming of Stem Cells for Spinal Cord Repair

Advanced Functional Materials, EarlyView.
Schematic illustration of LNP‐MPG nuclei‐targeting delivery of HMW‐FGF2 promoting histone acetylation to regulate the fate of DPSCs and treat spinal cord injury. LNPs components include pHMW‐FGF2 plasmid, DSPC, Dlin‐MC3‐DMA, cholesterol, and PEG2000, and are modified with MPG to form HMW‐FGF2@LNP‐MPG (HLM). HLM nuclei‐targets DPSCs to deliver HMW‐FGF2,
Heng Zhou, Qiang Qin, Xiqin Li, Hanyu Ding, Chun Xu, Yan He, Qingsong Ye   +6 more
wiley   +1 more source

NEVBD Quarterly Digest Issue 6

, 2020
The Northeast Regional Center for Excellence in Vector-Borne Diseases is supported through Cooperative Agreement Number 1U01CK000509-01 between the Centers for Disease Control and Prevention (CDC) and Cornell UniversityThe Northeast Regional Center for ...
Northeast Regional Center for Excellence in Vector-Borne Diseases
core   +4 more sources

Role of immune cell subsets in the establishment of vector‐borne infections [PDF]

European Journal of Immunology, 2012
Many of the pathogens responsible for diseases that result in both economic and global health burdens are transmitted by arthropod vectors in the course of a blood meal. In the past, these vectors were viewed mainly as simple delivery vehicles but the appreciation of the role that factors in the saliva of vectors play during pathogen transmission is ...
Wolfgang W, Leitner, Adriana, Costero-Saint Denis, Tonu, Wali   +2 more
openaire   +2 more sources

Vector-Borne Zoonotic Pathogens in Eurasian Moose (Alces alces alces)

, 2019
Climate change, with warmer temperatures and altered precipitation patterns, has affected the distribution of vectors and vector-borne diseases. In the northern hemisphere, vectors are spreading north, and with them, pathogens of zoonotic and animal ...
Sveriges lantbruksuniversitet., Dalin, Anne-Marie,, Malmsten, Jonas,, Felton, Annika,   +3 more
core   +1 more source

Mosquitoes in Malta: Preliminary entomological investigation and risk assessment for vector-borne diseases (Diptera: Culicidae) [PDF]

, 2010
At the request of Malta’s Infectious Disease Prevention and Control Unit (IDCU), the European Centre for Disease Prevention and Control (ECDC) organized an expert mission in Malta in 2009 to provide support for a vector-borne disease (VBD) risk ...
Spiteri, G, Mall, S, Melillo Fenech, Tanya, Schaffner, Francis; https://orcid.org/, Schaffner, Francis, Mall, Sabine, Maroli, Michele, Zeller, H, Zeller, Herve, Maroli, M, Melillo, T, Gatt, Paul, Gianfranco, Spiteri, Gatt, P   +13 more
core   +1 more source

How is Nanoarchitectonics Shaping Extracellular Vesicle Research?

Advanced Healthcare Materials, EarlyView.
The convergence of nanoarchitectonics and extracellular vesicle biology is reshaping next‐generation nanomedicine by enabling rationally designed nanostructures for enhanced EVs detection, engineering, and therapy. ABSTRACT Extracellular vesicles (EVs) have gained recognition as crucial mediators of cell‐to‐cell communication, holding immense potential
Madushani Dahanayake, Md Shahriar A. Hossain, Chia‐Hung Liu, Carlos Salomon, Yusuke Yamauchi, Mostafa Kamal Masud   +5 more
wiley   +1 more source

Improved antibody breadth with an extended primary dose interval of COVID-19 vaccine is overcome by boosters

Frontiers in Immunology
IntroductionDuring rollout of mRNA-based COVID-19 vaccines, several jurisdictions extended the interval between the first and second doses to prioritize wider population access to limited vaccine supply.
Jessica I. Ahmed, Samantha J. Krosta, Mandy N. Reimer, Winnie Cheung, Christine Mesa, Carmen Lopez, Rayeil J. Chua, Farah Alsattari, Alyssia Robinson, Kathy Manguiat, Naima Jahan, Bernard Abrenica, Angela Harris, Karla Cachero, Rissa Fabia, Jonathan Walker, Myo Minn Oo, Derek Stein, Derek Stein, Hezhao Ji, Hezhao Ji, Ruey-Chyi Su, Ruey-Chyi Su, Paul J. McLaren, Paul J. McLaren, Lyle R. McKinnon, Lyle R. McKinnon, Lyle R. McKinnon, T Blake Ball, T Blake Ball, Heidi Wood, John Kim, Sandra A. Kiazyk, Sandra A. Kiazyk, Catherine M. Card, Catherine M. Card   +35 more
doaj   +1 more source