Results 71 to 80 of about 119,802 (171)

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Development of a Virtual Telehandler Model Using a Bond Graph

Machines
Recent technological advancements and evolving regulatory frameworks are catalysing the integration of renewable energy sources in construction equipment, with the objective of significantly reducing greenhouse gas emissions.
Beatriz Puras, Gustavo Raush, Javier Freire, Germán Filippini, Pedro Roquet, Manel Tirado, Oriol Casadesús, Esteve Codina   +7 more
doaj   +1 more source

Finite pseudo orbit expansions for spectral quantities of quantum graphs

, 2012
We investigate spectral quantities of quantum graphs by expanding them as sums over pseudo orbits, sets of periodic orbits. Only a finite collection of pseudo orbits which are irreducible and where the total number of bonds is less than or equal to the ...
Berkolaiko G, Berkolaiko G, Berry M V, Bogomolny E, C H Joyner, Comtet A, Desbois J, Edmunds D E, Gutzwiller M, Haake F, Harmer M, Harrison J M, Harrison J M, Harrison J M, Harrison J M, Harrison J M, J M Harrison, Keating J P, Kirsten K, Kostrykin V, R Band, Roth J P, Rueckriemen R, Tanner G, Tanner G   +24 more
core   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Scattering theory on graphs

, 2001
We consider the scattering theory for the Schr\"odinger operator $-\Dc_x^2+V(x)$ on graphs made of one-dimensional wires connected to external leads. We derive two expressions for the scattering matrix on arbitrary graphs.
Adamyan V, Avron J E, Avron J E, Berkolaiko G, Berkolaiko G, Biggs N, Carlson R, Christophe Texier, Chung F, Colin de Verdière Y, Cvetkovic D M, Desbois J, Desbois J, Douçot B, Douçot B, Exner P, Gerasimenko N I, Gilles Montambaux, Kostrykin V, Pannetier B, Pascaud M, Roth J-P, Roth J-P, Rudenberg K, Vidal J   +24 more
core   +3 more sources

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source

Structure–Function Decoupling of the Sensorimotor and Default Mode Networks in Black Americans With MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Multiple sclerosis (MS) exhibits racially disparate rates of disease progression. Black people with MS (B‐PwMS) experience a more severe disease course than non‐Hispanic White people with MS (NHW‐PwMS). Here we investigated structural and functional connectivity as well as structure–function decoupling in the ...
Emilio Cipriano, Giacomo Boffa, Maria Petracca, Marta Ponzano, Nicole Graziano, Claire Wigley, Claire Riley, Jonathan Howard, Pietro Bontempi, Sylvia Klineova, Fred Lublin, Matilde Inglese   +11 more
wiley   +1 more source

Duality and free energy analyticity bounds for few-body Ising models with extensive homology rank [PDF]

, 2019
We consider pairs of few-body Ising models where each spin enters a bounded number of interaction terms (bonds) such that each model can be obtained from the dual of the other after freezing k spins on large-degree sites.
Dumer, Ilya, Jiang, Yi, Kovalev, Alexey, Pryadko, Leonid   +3 more
core   +1 more source