Results 51 to 60 of about 21,465 (238)
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Bond Graph Modeling of a Robot Manipulator [PDF]
, 2015 A good modelling of the specific manipulator needs an efficient method to describe all behaviors of system.In this paper we propose a new approach for modelling a robot arm based on Bond Graph methodology.
Baghli, Fatima Zahra
core
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Nuclear reactor multiphysics via bond graph formalism [PDF]
, 2014 Thesis: Sc. D., Massachusetts Institute of Technology, Department of Nuclear Science and Engineering, 2014.This electronic version was submitted by the student author.
Sosnovsky, Eugeny, Eugeny Sosnovsky
core
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Frontiers in PhysicsIntroductionThe increasing complexity and non-linearity of financial markets make traditional linear models inadequate for systemic risk assessments. This study aims to develop a new framework for identifying outlier events and critical transitions in ...
Hao Li +4 more
doaj +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Jixie chuandong, 2010 As friction and clearance exist in mechanism kinematic pair simultaneously,the modeling and computation would be very complicated. A nonlinear model of the hinge is built by using switch bond graph and it is embedded into the vector bond graph modeling ...
王艾伦, 潘竞香
doaj
A dynamic programming algorithm for generating chemical isomers based on frequency vectors
Scientific ReportsWe propose a dynamic programming algorithm that generates chemical isomers of a given chemical compound with cycles. We represent a chemical compound as a chemical graph and define its feature vector based on graph-theoretical descriptors.
Ryota Ido +4 more
doaj +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source