Results 41 to 50 of about 21,465 (238)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

A Computer Aided Kineto-Static Analysis Method for 3-RRRT Parallel Manipulator Based on Vector Bond Graph [PDF]

The Open Automation and Control Systems Journal, 2013
For improving the reliability and efficiency of the kineto-static analysis of complex robot systems, the corre- sponding vector bond graph procedure is proposed. By the kinematic constraint condition, the vector bond graph model of universal joint are made. Based on this, the vector bond model of 3-RRRT parallel Manipulator is built.
openaire   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

A natural scheme for the quantitative analysis of the magnetically induced molecular current density using an oriented flux-weighted stagnation graph. I. A minimal example for LiH [PDF]

, 2022
A new natural scheme is introduced to analyze quantitatively the magnetically induced molecular current density vector field, J. The set of zero points of J, which is called its stagnation graph (SG), has been previously used to study the topological ...
Berger, Raphael J. F., Dimitrova, Maria
core   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Bond graph models of DC-DC converters operating in both CCM and DCM [PDF]

, 2014
In this paper, Bond Graphs are employed to develop a novel mathematical model of conventional switched-mode DC-DC converters valid for both continuous and discontinuous conduction modes.
Potter, Ben, Markakis, Antonios, Holderbaum, William   +2 more
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Intermittent predictive control of an inverted pendulum [PDF]

, 2006
Intermittent predictive pole-placement control is successfully applied to the constrained-state control of a prestabilised experimental inverted ...
Gawthrop, P.J., Wang, L.
core   +1 more source

Modeling and Analysis of Dynamics of Rigid–Flexible Coupled Parallel Robots

Applied Sciences
Rigid–flexible coupled robots have problems such as vibration and elastic deformation caused by the flexibility of the members during the motion process, which significantly impacts the system’s motion accuracy and dynamics performance.
Leilei Wang, Wei Xu, Fei Guo, Hao Yan, Yunxue Wang   +4 more
doaj   +1 more source

Bond Graph Modeling of a Planar Vehicle with Electric Traction Motors for Assisted Torque-Vectoring

, 2021
Powertrains for vehicles are transitioning from the internal combustion engine to electric motors. Electric motors have the ability to both output traction and generative braking torque. Furthermore, electric motor powertrains have a smaller size compared to the internal combustion engine powertrain.
Lee, Donghun, Loyola, Jonathan, McCrone, Jordan, Margolis, Donald   +3 more
openaire   +1 more source