Results 41 to 50 of about 120,896 (238)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Spectral Statistics for the Dirac Operator on Graphs

, 2002
We determine conditions for the quantisation of graphs using the Dirac operator for both two and four component spinors. According to the Bohigas-Giannoni-Schmit conjecture for such systems with time-reversal symmetry the energy level statistics are ...
Alonso V, Berkolaiko G, Berkolaiko G, Berry M V, Bolte J, Bolte J, Bulla W, Gantmacher F R, Haake F, Jens Bolte, Jonathan Harrison, Keppeler S, Kostrykin V, Kottos T, Roth J-P, Scharf R, Scharf R, Thaha M, Thaller B   +18 more
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Complete-Graph Tensor Network States: A New Fermionic Wave Function Ansatz for Molecules [PDF]

, 2010
We present a new class of tensor network states that are specifically designed to capture the electron correlation of a molecule of arbitrary structure. In this ansatz, the electronic wave function is represented by a Complete-Graph Tensor Network (CGTN)
Bela Bauer, Changlani H J Kinder J M Umrigar C J Chan G K-L, Cirac J I Verstraete F, Derrida B, Eisert J Cramer M Plenio M B, Frank Verstraete, Frenkel D, Harvey J N, Helgaker T, Katzgraber H G, Klümper A, Konrad H Marti, Markus Reiher, Marti K H, Matthias Troyer, McCulloch I P, Mezzacapo F, Moritz G Marti K H Reiher M, Nishio Y Maeshima N Gendiar A Nishino T, Perez-Garcia D, Reiher M, Sierra G Martin-Delgado M A, Werner H J   +22 more
core   +2 more sources

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Bond Graph Based Stability Analysis of a Railway Traction System [PDF]

, 2005
This paper emphasises the interest of the Bond Graph approach for analysis and system design of heterogeneous and multi-field devices. In particular, the local stability analysis of non linear systems can be directly derived from the linearised Causal ...
Dauphin-Tanguy, Geneviève, Gandanegara, Grace, Roboam, Xavier, Sareni, Bruno   +3 more
core   +1 more source

General duality for abelian-group-valued statistical-mechanics models

, 2003
We introduce a general class of statistical-mechanics models, taking values in an abelian group, which includes examples of both spin and gauge models, both ordered and disordered.
Andrea Sportiello, Caracciolo S, Caracciolo S Sportiello A, Caracciolo S Sportiello A, Drühl K, Gruber C, Gruber C, Hewitt E, Kirillov A A, Lee D-H, Mc Kean H P, Nienhuis B, Oxley J, Peskin M E, Potts R B, Savit R, Sergio Caracciolo, Villain J, Whitney H, Wu F Y   +19 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

A Computer Aided Kineto-Static Analysis Method for 3-RRRT Parallel Manipulator Based on Vector Bond Graph [PDF]

The Open Automation and Control Systems Journal, 2013
For improving the reliability and efficiency of the kineto-static analysis of complex robot systems, the corre- sponding vector bond graph procedure is proposed. By the kinematic constraint condition, the vector bond graph model of universal joint are made. Based on this, the vector bond model of 3-RRRT parallel Manipulator is built.
openaire   +1 more source

Infinite Matroids and Determinacy of Games [PDF]

, 2013
Solving a problem of Diestel and Pott, we construct a large class of infinite matroids. These can be used to provide counterexamples against the natural extension of the Well-quasi-ordering-Conjecture to infinite matroids and to show that the class of ...
Bowler, Nathan, Carmesin, Johannes
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