Results 51 to 60 of about 37,265 (258)

Entomological assessment of dengue virus transmission risk in three urban areas of Kenya.

PLoS Neglected Tropical Diseases, 2019
Urbanization is one of the major drivers of dengue epidemics globally. In Kenya, an intriguing pattern of urban dengue virus epidemics has been documented in which recurrent epidemics are reported from the coastal city of Mombasa, whereas no outbreaks ...
Sheila B Agha, David P Tchouassi, Michael J Turell, Armanda D S Bastos, Rosemary Sang   +4 more
doaj   +1 more source

Aedes aegypti vector competence studies: A review

Infection, Genetics and Evolution, 2019
Aedes aegypti is the primary transmitter of the four viruses that have had the greatest impact on human health, the viruses causing yellow fever, dengue fever, chikungunya, and Zika fever. Because this mosquito is easy to rear in the laboratory and these viruses grow in laboratory tissue culture cells, many studies have been performed testing the ...
Jayme A. Souza-Neto, Jeffrey R. Powell, Mariangela Bonizzoni   +2 more
openaire   +4 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Analysis of switching dynamics with competing support vector machines [PDF]

Proceedings of the 2002 International Joint Conference on Neural Networks. IJCNN'02 (Cat. No.02CH37290), 2003
We present a framework for the unsupervised segmentation of switching dynamics using support vector machines. Following the architecture by Pawelzik et al., where annealed competing neural networks were used to segment a nonstationary time series, in this paper, we exploit the use of support vector machines, a well-known learning technique.
Chang, Ming-Wei, Lin, Chih-Jen, Weng, R.C.   +2 more
openaire   +3 more sources

The neovolcanic axis is a barrier to gene flow among Aedes aegypti populations in Mexico that differ in vector competence for Dengue 2 virus. [PDF]

PLoS Neglected Tropical Diseases, 2009
Aedes aegypti is the main mosquito vector of the four serotypes of dengue virus (DENV). Previous population genetic and vector competence studies have demonstrated substantial genetic structure and major differences in the ability to transmit dengue ...
Saul Lozano-Fuentes, Ildefonso Fernandez-Salas, Maria de Lourdes Munoz, Julian Garcia-Rejon, Ken E Olson, Barry J Beaty, William C Black   +6 more
doaj   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Bacillus sphaericus exposure reduced vector competence of Anopheles dirus to Plasmodium yoelii by upregulating the Imd signaling pathway

Parasites & Vectors, 2020
Background Vector control with Bacillus sphaericus (Bs) is an effective way to block the transmission of malaria. However, in practical application of Bs agents, a sublethal dose effect was often caused by insufficient dosing, and it is little known ...
Shasha Yu, Pan Wang, Jie Qin, Hong Zheng, Jing Wang, Tingting Liu, Xuesen Yang, Ying Wang   +7 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

The Vector Model of Competence Diagnostics

Mediterranean Journal of Social Sciences, 2015
The article summarizes the results of the theoretical study of the problem of diagnostics designing that takes into account the multidimensional nature of competence. Competences aggregate inconsistent components. Therefore, in order to describe them, it is natural to apply the category of multidimensionality.
Andrei Viktorovich Dorofeev, Al'fiia Faizrakhmanovna Latypova   +1 more
openaire   +2 more sources

Secondary vectors of Zika Virus, a systematic review of laboratory vector competence studies

PLOS Neglected Tropical Diseases, 2023
Background After the unprecedented Zika virus (ZIKV) outbreak in the western hemisphere from 2015–2018, Aedes aegypti and Ae. albopictus are now well established primary and secondary ZIKV vectors, respectively. Consensus about identification and importance of other secondary ZIKV vectors remain. This systematic review aims to provide a list of vector
Marina Bisia, Carlos Alberto Montenegro-Quiñonez, Peter Dambach, Andreas Deckert, Olaf Horstick, Antonios Kolimenakis, Valérie R. Louis, Pablo Manrique‐Saide, Αntonios Michaelakis, Silvia Runge‐Ranzinger, Amy C. Morrison   +10 more
openaire   +5 more sources