Results 41 to 50 of about 38,935 (247)

AscF in the mycobacterial CIII–CIV supercomplex lacks metal and nucleotide binding but links malate oxidation to respiration

FEBS Letters, EarlyView.
The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile, Riccardo Diamanti, Daniel Lundin, Soni Sharma, Robin Lissner, Coenraad P. Kuil, Martin Högbom, Dirk Bald, Dan Sjöstrand   +8 more
wiley   +1 more source

Identifying Knowledge Gaps through the Systematic Review of Temperature-Driven Variability in the Competence of Aedes aegypti and Ae. albopictus for Chikungunya Virus

Pathogens, 2023
Temperature is a well-known effector of several transmission factors of mosquito-borne viruses, including within mosquito dynamics. These dynamics are often characterized by vector competence and the extrinsic incubation period (EIP).
Rebecca C. Christofferson, Erik A. Turner, Víctor Hugo Peña-García   +2 more
doaj   +1 more source

Entomological assessment of dengue virus transmission risk in three urban areas of Kenya.

PLoS Neglected Tropical Diseases, 2019
Urbanization is one of the major drivers of dengue epidemics globally. In Kenya, an intriguing pattern of urban dengue virus epidemics has been documented in which recurrent epidemics are reported from the coastal city of Mombasa, whereas no outbreaks ...
Sheila B Agha, David P Tchouassi, Michael J Turell, Armanda D S Bastos, Rosemary Sang   +4 more
doaj   +1 more source

The neovolcanic axis is a barrier to gene flow among Aedes aegypti populations in Mexico that differ in vector competence for Dengue 2 virus. [PDF]

PLoS Neglected Tropical Diseases, 2009
Aedes aegypti is the main mosquito vector of the four serotypes of dengue virus (DENV). Previous population genetic and vector competence studies have demonstrated substantial genetic structure and major differences in the ability to transmit dengue ...
Saul Lozano-Fuentes, Ildefonso Fernandez-Salas, Maria de Lourdes Munoz, Julian Garcia-Rejon, Ken E Olson, Barry J Beaty, William C Black   +6 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Bacillus sphaericus exposure reduced vector competence of Anopheles dirus to Plasmodium yoelii by upregulating the Imd signaling pathway

Parasites & Vectors, 2020
Background Vector control with Bacillus sphaericus (Bs) is an effective way to block the transmission of malaria. However, in practical application of Bs agents, a sublethal dose effect was often caused by insufficient dosing, and it is little known ...
Shasha Yu, Pan Wang, Jie Qin, Hong Zheng, Jing Wang, Tingting Liu, Xuesen Yang, Ying Wang   +7 more
doaj   +1 more source

Vector competence of Florida mosquitoes for chikungunya virus [PDF]

Journal of Vector Ecology, 2010
Chikungunya virus (CHIKV, family Togaviridae, genus Alphavirus) has re-emerged and caused human epidemics in Europe, Africa, Asia, and India in recent years (Bessaud et al. 2006, Powers and Logue 2007, Peyrefitte et al. 2008, Leo et al. 2009). The debilitating disease caused by CHIKV results in fever, skin rash, and arthritis-like pain in small ...
Stephanie L, Richards, Sheri L, Anderson, Chelsea T, Smartt   +2 more
openaire   +2 more sources

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

The Vector Model of Competence Diagnostics

Mediterranean Journal of Social Sciences, 2015
The article summarizes the results of the theoretical study of the problem of diagnostics designing that takes into account the multidimensional nature of competence. Competences aggregate inconsistent components. Therefore, in order to describe them, it is natural to apply the category of multidimensionality.
Andrei Viktorovich Dorofeev, Al'fiia Faizrakhmanovna Latypova   +1 more
openaire   +2 more sources

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source