Results 51 to 60 of about 38,680 (247)

Experimental infection and vector competence of Zika virus in Aedes aegypti mosquitoes from Acapulco, Guerrero, Mexico

Salud Pública de México, 2020
Objective. To gain a better understanding of the Zika virus (ZIKV) vector transmission in Mexico, we determined the vector competence of a local population of Ae. aegypti (Aca­pulco, Guerrero) for a strain of ZIKV isolated from a Mexican febrile patient.
Nayeli Sánchez-Casiano, Jorge Cime-Castillo, Marbella Ovilla-Muñoz, Judith Ramírez-Arroyo, Casandra González-Acosta, Miguel Moreno-García, Fabián Correa-Morales, Victoria Pando-Robles   +7 more
doaj   +1 more source

Identifying Knowledge Gaps through the Systematic Review of Temperature-Driven Variability in the Competence of Aedes aegypti and Ae. albopictus for Chikungunya Virus

Pathogens, 2023
Temperature is a well-known effector of several transmission factors of mosquito-borne viruses, including within mosquito dynamics. These dynamics are often characterized by vector competence and the extrinsic incubation period (EIP).
Rebecca C. Christofferson, Erik A. Turner, Víctor Hugo Peña-García   +2 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

The Vector Model of Competence Diagnostics

Mediterranean Journal of Social Sciences, 2015
The article summarizes the results of the theoretical study of the problem of diagnostics designing that takes into account the multidimensional nature of competence. Competences aggregate inconsistent components. Therefore, in order to describe them, it is natural to apply the category of multidimensionality.
Andrei Viktorovich Dorofeev, Al'fiia Faizrakhmanovna Latypova   +1 more
openaire   +2 more sources

Entomological assessment of dengue virus transmission risk in three urban areas of Kenya.

PLoS Neglected Tropical Diseases, 2019
Urbanization is one of the major drivers of dengue epidemics globally. In Kenya, an intriguing pattern of urban dengue virus epidemics has been documented in which recurrent epidemics are reported from the coastal city of Mombasa, whereas no outbreaks ...
Sheila B Agha, David P Tchouassi, Michael J Turell, Armanda D S Bastos, Rosemary Sang   +4 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

The neovolcanic axis is a barrier to gene flow among Aedes aegypti populations in Mexico that differ in vector competence for Dengue 2 virus. [PDF]

PLoS Neglected Tropical Diseases, 2009
Aedes aegypti is the main mosquito vector of the four serotypes of dengue virus (DENV). Previous population genetic and vector competence studies have demonstrated substantial genetic structure and major differences in the ability to transmit dengue ...
Saul Lozano-Fuentes, Ildefonso Fernandez-Salas, Maria de Lourdes Munoz, Julian Garcia-Rejon, Ken E Olson, Barry J Beaty, William C Black   +6 more
doaj   +1 more source

Analysis of switching dynamics with competing support vector machines [PDF]

Proceedings of the 2002 International Joint Conference on Neural Networks. IJCNN'02 (Cat. No.02CH37290), 2003
We present a framework for the unsupervised segmentation of switching dynamics using support vector machines. Following the architecture by Pawelzik et al., where annealed competing neural networks were used to segment a nonstationary time series, in this paper, we exploit the use of support vector machines, a well-known learning technique.
Ming-Wei Chang, Chih-Jen Lin, Ruby Chiu-Hsing Weng   +2 more
openaire   +3 more sources

Bacillus sphaericus exposure reduced vector competence of Anopheles dirus to Plasmodium yoelii by upregulating the Imd signaling pathway

Parasites & Vectors, 2020
Background Vector control with Bacillus sphaericus (Bs) is an effective way to block the transmission of malaria. However, in practical application of Bs agents, a sublethal dose effect was often caused by insufficient dosing, and it is little known ...
Shasha Yu, Pan Wang, Jie Qin, Hong Zheng, Jing Wang, Tingting Liu, Xuesen Yang, Ying Wang   +7 more
doaj   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source