Results 121 to 130 of about 113,958,312 (241)
Polymorphism of the PPARG, AGTR1, VEGF-A genes: frequency and association with obesity phenotypes
Российский кардиологический журналAim. To assess the association of the allele and genotype frequencies of following single nucleotide polymorphisms: rs1801282 of the peroxisome proliferator-activated receptor gamma (PPARG) gene, rs5186 of the angiotensin II receptor type 1 (AGTR1) gene,
A. E. Bragina +7 more
doaj +1 more source
Advanced Science, EarlyView.This study unravels that bone fracture accelerates diabetic wound healing by releasing exosomal microRNA (miR‐130b‐3p). To mimic this bone‐skin crosstalk, we engineered a self‐assembling agomir‐130b‐3p nanocomplex. Delivered via a photocrosslinkable hydrogel, this bio‐inspired therapy provides sustained localized agomir release.
Tao Shen +14 more
wiley +1 more source
Dual Blockade of LILRB1 and LILRB2 Enhances Antiviral Immune Responses in SIV Infection
Advanced Science, EarlyView.Dual LILRB1/B2 blockade with mac20G10 reshapes myeloid activation during acute SIV infection by targeting LILRB1 and LILRB2 on myeloid cells. This treatment enhances CD80 expression on selected myeloid subsets and increases plasma IFN‐λ, IL‐8, and IL‐1RA.
Florian Meurisse +20 more
wiley +1 more source
Advanced Science, EarlyView.ABSTRACT Bacterial wound infections, particularly those caused by Escherichia coli and Pseudomonas aeruginosa, are difficult to treat due to biofilm formation, multidrug resistance, and chronic inflammation. Here, we report a multifunctional nanoplatform based on a surface‐enhanced Raman scattering (SERS) probe that enables simultaneous photodynamic ...
Hanbin Deng +6 more
wiley +1 more source
VEGF-A level is significantly higher in the wound of E2F1–/– mice than in WT mice.
, 2016 Wound tissues were isolated at day 7 post-surgery. (A) Immumohistochemical staining of VEGF (brown), 20X original magnification (left panels), the inlets were enlarged (right panels). (B) VEGF mRNA expression was analyzed by qRT-PCR and normalized to the
Andrew Wang (353056) +14 more
core +1 more source
Advanced Science, EarlyView.A thermo‐responsive rectal delivery platform integrating probiotic‐derived extracellular vesicles within a hyaluronic acid‐based copolymer enables localized and sustained therapy for ulcerative colitis. The formulation effectively suppresses inflammation, promotes macrophage polarization toward a regenerative phenotype, restores epithelial barrier ...
Ayushi Mairal +5 more
wiley +1 more source
VEGF-A and VEGFR2 as candidate pathway in NVU OPC recruitment.
, 2019 a-i Representative confocal images of cerebral cortex sections from EAE-affected WT mice, immunolabelled for growth factors and their receptors: VEGF-A and its receptor VEGFR2 (a-c), FGF2 and its receptor FGFR1 (d-f), PDGF-AA/PDGFRα (g, h) and TGFβ (i ...
Carlotta Alias (6459365) +10 more
core +1 more source
Neovascular age-related macular degeneration management – Beyond anti-VEGF
Indian Journal of OphthalmologyIntravitreal anti-vascular endothelial growth factor (VEGF) therapy has transformed neovascular age-related macular degeneration (nAMD) into a chronic, treatable condition.
Apoorva Ayachit +7 more
doaj +1 more source
Advanced Science, EarlyView.In bladder cancer, LRG1 binds to ANXA2 to trigger mitochondrial ROS‐dependent NETosis. This pathogenic cascade actively uncouples endothelial‐mural cell interactions, driving profound vascular destabilization. Consequently, targeting the LRG1‐ANXA2 axis attenuates the neutrophil burden and induces structural vascular normalization, offering a powerful ...
Dongshan Chen +8 more
wiley +1 more source