Results 131 to 140 of about 113,958,312 (241)

The level of VEGF-A in the lacrimal fluid of diabetic retinopathy

open access: yesКубанский научный медицинский вестник, 2015
The lacrimal fluid was investigated in 56 people (95 eyes) with type II diabetes, of which 11 (11 eyes) with no signs of diabetic retinopathy and 45 patients (84 eyes) suffering from diabetic retinopathy of varying severity.
Yu. A. Borzilova   +4 more
doaj  

TPI1 Loss Triggers a Metabolite‐Driven Mitochondrial Redox Vulnerability via the SARM1–cADPR–Ca2+ Axis

open access: yesAdvanced Science, EarlyView.
Metabolite‐driven redox stress governs cancer cell senescence. TPI1 deficiency elevates DHAP, initiating SARM1‐dependent cADPR‐Ca2+ release. Mitochondrial ROS surge subsequently induces DNA damage and senescence, offering a conserved therapeutic target in multiple cancers.
Chunyu Liu   +15 more
wiley   +1 more source

VEGF-A splicing patterns in whole kidney tissue obtained from mice with DN, healthy age-matched control mice and mice with lupus nephritis.

open access: yes, 2016
A The VEGF-A 120, 144, 164, and 188 isoforms were measured in whole kidney tissue obtained from mice with early-stage DN and age-matched control mice. The two groups did not differ significantly with respect to any isoform measured (p>0.05).
H. J. Baelde (3105789)   +4 more
core   +1 more source

VEGF-A expression in fat grafts (experimental study)

open access: yesActa Biomedica Scientifica
The study of vascularization of fat implants is focused on the assessment of specific external and/or internal factors affecting its stimulation.The aim.
I. V. Kastyro   +8 more
doaj   +1 more source

CA9‐Targeted PET Imaging for Noninvasive Discrimination of Clear Cell Renal Cell Carcinoma and Associated Tumor Biological Features

open access: yesAdvanced Science, EarlyView.
CA9‐targeted PET imaging could be a noninvasive approach to characterize clear cell renal cell carcinoma and associated tumor biology. PET uptake correlates with tumor CA9 expression and is linked to angiogenic activity, immune remodeling, and metabolic reprogramming.
Kailei Chen   +19 more
wiley   +1 more source

Harmonizing Rigidity and Flexibility: Embedding COF Quantum Dots Into Extracellular Matrix Gel as Carbon Monoxide Depot for Acoustically Triggered Time‐Programmable Anti‐Infective Therapy

open access: yesAdvanced Science, EarlyView.
A rigid‑flexible integrated CO depot is engineered by embedding rigid COFQDs into a flexible ECM gel network. The rigid framework enables high‑capacity CO storage and sonodynamic bacterial killing, while the flexible ECM gel controls sustained CO release, collectively eradicating multidrug‑resistant infection and promoting scarless healing.
Baohong Sun   +13 more
wiley   +1 more source

Pasta, a Versatile Transcriptomic Clock, Maps the Chemical and Genetic Determinants of Aging and Rejuvenation

open access: yesAdvanced Science, EarlyView.
Pasta is a transcriptomic aging clock built on an age‐shift learning framework and trained on 17 000 samples across 21 datasets. It accurately predicts relative biological age across tissues, platforms, and species, captures stemness‐to‐senescence transitions, and identifies age‐modulatory perturbations.
Jérôme Salignon   +6 more
wiley   +1 more source

Clinical Significance of Anti-VEGF Therapy

open access: yes
This thesis compiles recent data on the uses, effectiveness and side effects of anti-VEGF therapy. It demonstrates its significance in the fields of oncology, ophthalmology and cardiology. The thesis dwells deeper into the clinical significance of anti-
Agranovski , Yaran
core  

Multifunctional Manganese Oxide Nanocomposite Hydrogel With Synergistic Reactive Oxygen Species‐Scavenging, Oxygen‐Generating, Immunomodulatory, and Photothermal Antimicrobial Activities for Enhanced Diabetic Wound Healing

open access: yesAdvanced Science, EarlyView.
CFP/PC@MnO2 hydrogel integrates ROS scavenging, oxygen delivery, oxidative stress reduction, immunomodulation, and photothermal antibacterial properties. The incorporation of PC@MnO2 NPs endows the hydrogel with multiple functional advantages tailored to the pathological microenvironment of diabetic wounds, including efficient ROS clearance, mitigation
Zhi Xu   +9 more
wiley   +1 more source

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