Results 121 to 130 of about 20,098,805 (300)

Selenium Nanoparticles Selectively Target KRAS G13D to Inhibit Colorectal Cancer

Advanced Science, EarlyView.
The mechanisms of SeNPs therapy in cancer treatment, encompass three parallel actions: (1) seleno‐amino acids, key metabolites, upregulate GPX2 expression, thereby inhibiting tumor metastasis via the GPX2‐HIF1α‐VEGF signaling pathway; (2) selenite (SeO32−), an inorganic metabolite, forms hydrogen bonds with amino acid residues 13–17 of the KRAS G13D ...
Xiaoting Liu, Chong Wu, Shiyao Song, Li Ma, Shaoqing Huang, Yuting He, Qinghai Li, Yanzhou Chang, Dan Jiang, Yong Mei, Junchao Cai, Zhenshuang Du, Tianfeng Chen, Weiling He   +13 more
wiley   +1 more source

The lymphangiogenic growth factors VEGF-C and VEGF-D : Part 1: Basic principles and embryonic development [PDF]

, 2013
VEGF-C and VEGF-D are the two central signaling molecules that stimulate the development and growth of the lymphatic system. Both belong to the vascular endothelial growth factor (VEGF) protein family, which plays important roles in the growth of blood ...
Krebs, Rainer, Jeltsch, Michael
core  

The correlation of circulating vascular endothelial growth factor-A (VEGF-A) or C (VEGF-C) levels with their independent determinants.

, 2013
A. The correlation between circulating VEGF-A levels and the body mass index. B. The correlation between those of VEGF-C and those of triglycerides. C. The correlation between those of VEGF-C and those of non-high-density-lipoprotein cholesterol (nonHDL ...
Toshinori Murayama (337152), Rieko Takanabe-Mori (337146), Takahiro Horie (337141), Hiromichi Wada (337134), Shuji Kitaoka (337137), Masaharu Akao (233558), Masatoshi Fujita (337157), Koji Hasegawa (337158), Shuichi Ura (337136), Mitsuru Abe (337148), Tomohide Takaya (337145), Noriko Satoh-Asahara (337139), Koh Ono (337143), Tatsuya Morimoto (337150), Akira Shimatsu (308226), Masayuki Yokode (337155)   +15 more
core   +1 more source

In Situ Genetic Engineering Facilitates MMP‐9‐Responsive TIMP1 Release Through Proteolytic Cleavage to Boost Diabetic Wound Healing

Advanced Science, EarlyView.
This study develops an MMP‐9‐responsive protein release system that transforms resident cells into drug depots through in situ genetic engineering. Anchored to the membrane, the therapeutic protein TIMP1 is selectively released upon MMP‐9 cleavage.
Yuan Zhang, Jiani Deng, Man Yee Cheung, Tingting Fu, Xufeng Qi, Dongqing Cai, Jianmin Sun, Gang Lu, Peng Shi, Wai‐Yee Chan, Xu Li, Hui Zhao   +11 more
wiley   +1 more source

Representative images of VEGF-A (A), VEGF-C (B), VEGF-D (C), and VEGFR3 (D) immunohistochemical staining in primary oral squamous cell carcinoma (original magnification, x100).

, 2015
VEGF-A, VEGF-C, and VEGF-D were mainly immunolocalized in the cytoplasm of tumor cells. VEGFR3 was localized in the cytoplasm and/or at the membrane of tumor cells. VEGF, vascular endothelial growth factr; VEGFR3, VEGF receptor 3.
Tomokazu Yoshizaki (407160), Naohiro Wakisaka (407153), Seiichi Yoshimoto (833098), Kazuhira Endo (407155), Yasuhisa Hasegawa (691533), Akihiro Shiotani (682360), Makiko Moriyama-Kita (833101), Junkichi Yokoyama (833100), Masashi Sugasawa (768211), Kouki Miura (833099)   +9 more
core   +1 more source

Regulating Cells Fate and Function to Facilitate Bone Regeneration via Designing Programmable Bio‐Interactive Materials

Advanced Science, EarlyView.
This article aims to elucidate the biological mechanisms of bone repair and the evolution of material design, highlighting key cellular and molecular processes. It further proposes strategies and prospects for programmable bio‐interactive materials, which enable precisely guided bone tissue regeneration by dynamically regulating cell behavior and the ...
Qingrui Fan, Fuming Cao, Junqiang Mao, Pengbin Yin, Licheng Zhang, Jianjun Wang, Peifu Tang   +6 more
wiley   +1 more source

胃癌患者血清VEGF-C的检测及其临床意义

Zhongguo shiyan zhenduanxue, 2007
目的探讨胃癌患者血清VEGF-C浓度水平与胃癌患者临床病理特征的相关性,血清VEGF-C水平与组织VEGF-C蛋白表达的关系以及二者对胃癌淋巴结转移的诊断价值。方法采用酶联免疫吸附技术（ELISA）对28例胃癌患者血清VEGF-C水平进行检测,同时应用免疫组化技术对28例胃癌组织标本进行VEGF-C蛋白表达进行检测。结果胃癌患者血清VEGF-C浓度水平明显高于健康对照组,P0.05.胃癌患者血清VEGF-C浓度水平与淋巴结转移 ...
赵金伟, 王广义, 陈英会, 孙明
doaj  

Programmable Paracrine‐Mimetic Microneedle System for Temporal Regulation of Cardiac Repair

Advanced Science, EarlyView.
Temporal signaling is encoded into a programmable paracrine‐mimetic microneedle patch via tris(2,2'‐bipyridyl)dichlororuthenium(II) hexahydrate/sodium persulfate‐tuned hydrogel microparticles that deliver TGF‐β, IGF‐1, and VEGF over phase‐matched 7‐, 14‐, and 28‐day windows.
Yichen Dai, Pengchong Du, Zhaoyang Wang, Surilige, Rangga Fokta, Renjian Tan, Xiqing Zhao, Shuoyi Zhang, Yuecheng Wang, Yixin Zhang, Ziliang Fu, Rui Gong, Cheng Jiang, Yisheng He, Qiguang Wang, Renke Li, Khoon Lim, Junnan Tang, Xiaolin Cui   +18 more
wiley   +1 more source

Application and Single‐Cell Regulation Mechanism of Engineered EVs Combined With 4D‐Printed Hydrogel for Infected Burn Repair

Advanced Science, EarlyView.
4D bioprinted hydrogel loaded with FGF2‐modified extracellular vesicles (4D@F‐EVs) targets dermal fibroblasts and elevates local wound FGF2 levels via sustained release of F‐EVs. It activates PI3K‐Akt signaling, restores critical KGF+ fibroblast–KGFR+ keratinocyte crosstalk, enhances robust angiogenesis and collagen deposition to efficiently repair ...
Xiaomin Wang, Xiaoyan Li, Xiao Xu, Kelun Zhang, Fengjiao Yu, Zhen Shang, Nailong Pan, Junlin Lv, Yiwei Xu, Yan Tang, Liang Zhang, Xiaotong Li, Taoyi Wang, Jing Tao, Jiaxu Song, Mengyu Zhang, Xin Ma, Dan Han, Xiaoying Kong, Wenhua Xu   +19 more
wiley   +1 more source

VEGF-A regulates the expression of VEGF-C in human retinal pigment epithelial cells

, 2006
AIM: To determine the expression and regulation of vascular endothelial growth factor C (VEGF-C), and its receptor VEGFR-3, in human retinal pigment epithelial (RPE) cells and to consider their angiogenic role in choroidal neovascularisation (CNV ...
Zhao, B., Ma, A., Boulton, Michael, Cai, Jun   +3 more
core   +1 more source