Results 111 to 120 of about 20,098,805 (300)

Anti-VEGF-A antibody does not recognize VEGF-A : Incubation with VEGF-A antibody

, 2011
This antibody recognizes the VEGF-A monomer (22.5 kDa) and dimer (45 kDa) in control and glaucomatous retinas (first two lanes). VEGF-A antibody does not recognize 25 ng, 100 ng, or 250 ng of VEGF-A recombinant protein in the same membrane (last three ...
Wei Huang (36889), Diane Darland (53480), Arjun Ray (53479), Cynthia L. Grosskreutz (53482), Ceren Ergorul (53478), Zhonghui K. Luo (53481)   +5 more
core   +1 more source

Self‐Sealing Microneedles Improve Precision and Reduce Reflux in Subretinal Cell Transplantation

Advanced Materials Technologies, EarlyView.
Ultrafine 49G microneedles enable subretinal delivery of induced pluripotent stem cell‐derived retinal pigment epithelial cells through a 50 µm outer diameter tip. Compared with conventional 38G microcannulas, these microneedles reduce cell suspension reflux in a rabbit model, highlighting the potential of microinvasive delivery instruments to improve ...
Jared Ching, Hinako Ichikawa, Aya Motoyoshi, Shin Tanaka, Liam Morrow, Satoshi Shirae, Noriko Sakai, Shohei Kitahata, Michiko Mandai, Kazuaki Kadonosono   +9 more
wiley   +1 more source

Expression of hypoxia inducible factor-1α and vascular endothelial growth factor-C in human chronic periodontitis

Journal of Dental Sciences, 2015
Background/purpose: Evidence shows that there is a relationship between hypoxia and inflammatory response in periodontitis. Hypoxia-inducible factor (HIF)-1α is a major regulator of energy homeostasis and cellular adaptation to low oxygen stress ...
Qing-Yan Shi, Shi-Guang Huang, Jing-Hua Zeng, Xiao-Guo Fang   +3 more
doaj   +1 more source

Aptamer‐Engineered Liposomal Platform Enables in Situ cDC1 Vaccination to Potentiate Immunotherapy in Prostate Cancer

Advanced Science, EarlyView.
Prostate cancer is immunologically ‘cold’, with scarce, dysfunctional type 1 conventional dendritic cells (cDC1s) that limit T cell priming. We introduce an aptamer‐targeted liposomedelivering FMS‐like tyrosine kinase 3 ligand (Flt3L) and chlorin e6 (Ce6). Ultrasound induces antigen release and cDC1s recruitment, creating an in situ cDC1 vaccine.
Jiayi Wang, Xuan Wang, Xinfeng Dai, Linxin Tian, Wencheng Shen, Xueliang Liu, Wei Xue, Jiahua Pan, Yu Yang   +8 more
wiley   +1 more source

Survivin regulates the expression of VEGF-C in lymphatic metastasis of breast cancer

Diagnostic Pathology, 2012
Background As a known regulator of apoptosis, survivin has positive relationship with lymphatic metastasis in breast cancer. This study aims to detect the difference in expression between survivin and vascular endothelial growth factor-C (VEGF-C) in ...
Cai Xiaopeng, Ma Shuai, Gu Ming, Zu Cong, Qu Wenzhi, Zheng Xinyu   +5 more
doaj   +1 more source

Pre‐Regenerative Endothelial Cells Empowered by Antler Blood Exosomes Orchestrate Peripheral Nerve Repair

Advanced Science, EarlyView.
The pre‐regenerative vascular niche (PVN) is essential for nerve repair, yet its endothelial blueprint remains unclear. We identified angiogenic ECs (AECs) as the dominant pre‐regenerative subset and found that antler blood–derived exosomes (AB‐EXO) promote repair via IMP3.
Jinsheng Huang, Qiang Chen, Aihua Jin, Xiaoqi Yang, Hui Zhou, Weiquan Gong, Jin Cheng, Jun Dai, Minjin Wang, Meihua Piao, Yuanyi Wang, Nan Zhou   +11 more
wiley   +1 more source

Co‐Delivery of Sustained Release Chondroitinase ABC‐37 With Human iPSC‐Derived Neural Progenitors Promotes Transplant Survival and Functional Recovery in a Rodent Model of Stroke

Advanced Science, EarlyView.
A regenerative strategy for stroke combines human stem cell–derived neural progenitor cells with sustained release of a matrix‐modifying, thermostable chondroitinase ABC‐37 enzyme. In a rat model of stroke, co‐delivery enhanced transplanted cell survival and neuronal differentiation, degraded inhibitory extracellular matrix components, and improved ...
Nitzan Letko Khait, David Xinzheyang Li, Keyi Guo, Hong Cui, Quinton Sirianni, Dhana Abdo, Cindi M. Morshead, Molly S. Shoichet   +7 more
wiley   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Tumor-induced VEGF-C overexpression in retroperitoneal lymph nodes in VX2 carcinoma-bearing rabbits

, 2015
Yong-Wen Huang,1,* Yun Zhou,1,* Chun-Yan Lan,1 Yin Wang,1 Yan-Ling Feng,1 Rong-Zhen Luo,2 Ji-Hong Liu1 1Department of Gynecology, 2Department of Pathology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China ...
Huang YW, Feng YL, Lan CY, Luo RZ, Liu JH, Zhou Y, Wang Y   +6 more
core  

Peripheral Blood Platelets Express VEGF-C and VEGF which Are Released during Platelet Activation

, 1998
SummaryVEGF-C is a recently characterised endothelial growth factor structurally related to vascular endothelial growth factor (VEGF). We studied the expression of VEGF-C and VEGF in the cells of peripheral blood and in the umbilical cord blood CD 34 ...
Arto Orpana, Ari Ristimäki, Ulla Wartiovaara, Hanna Mikkola, Riitta Lassila, Jaakko Kaukonen, Aarno Palotie, Petri Salven, Vladimir Joukov, Kari Alitalo, Markku Heikinheimo, Heikki Joensuu   +11 more
core   +1 more source