Results 1 to 10 of about 241,142 (235)

KLK3/PSA and cathepsin D activate VEGF-C and VEGF-D [PDF]

eLife, 2019
Vascular endothelial growth factor-C (VEGF-C) acts primarily on endothelial cells, but also on non-vascular targets, for example in the CNS and immune system.
Sawan Kumar Jha, Khushbu Rauniyar, Ewa Chronowska, Kenny Mattonet, Eunice Wairimu Maina, Hannu Koistinen, Ulf-Håkan Stenman, Kari Alitalo, Michael Jeltsch   +8 more
doaj   +2 more sources

Associations of VEGF-D levels with clinical manifestations in lymphangioleiomyomatosis: a cross-sectional analysis of 631 cases [PDF]

Orphanet Journal of Rare Diseases
Background Lymphangioleiomyomatosis (LAM) is a rare neoplastic disorder characterized predominantly by dyspnea, recurrent pneumothorax, chylous effusion and diffuse pulmonary cystic changes in women.
Luning Yang, Hanghang Wang, Chongsheng Cheng, Miaoyan Zhang, Danjing Hu, Yani Wang, Tengyue Zhang, Xiaoxin Zhang, Song Liu, Wenshuai Xu, Junya Liu, Jinrong Dai, Shuzhen Meng, Yanli Yang, Shao-Ting Wang, Xinlun Tian, Kai-Feng Xu   +16 more
doaj   +2 more sources

Plasma levels of the lymphangiogenic factors VEGF-C, VEGF-D, and CXCL-12 are elevated in advanced diabetic nephropathy [PDF]

Renal Failure
Objective Early biomarkers for diabetic nephropathy progression remain limited. This study aims to investigate whether plasma levels of VEGF-C, VEGF-D, and CXCL-12 can reflect the severity of diabetic kidney disease (DKD), and to evaluate their potential
Qingshan Tian, Fan Zhang, Zhichao Yang, Ji Miao, Hao Wu, Zhenzhong Zheng   +5 more
doaj   +2 more sources

Distinct Characteristics of VEGF‐D and VEGF‐C to Predict Mortality in Patients With Suspected or Known Coronary Artery Disease [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background VEGF‐D (vascular endothelial growth factor D) and VEGF‐C are secreted glycoproteins that can induce lymphangiogenesis and angiogenesis. They exhibit structural homology but have differential receptor binding and regulatory mechanisms.
Hiromichi Wada, Masahiro Suzuki, Morihiro Matsuda, Yoichi Ajiro, Tsuyoshi Shinozaki, Satoru Sakagami, Kazuya Yonezawa, Masatoshi Shimizu, Junichi Funada, Takashi Takenaka, Yukiko Morita, Toshihiro Nakamura, Kazuteru Fujimoto, Hiromi Matsubara, Toru Kato, Takashi Unoki, Daisuke Takagi, Kyohma Wada, Miyaka Wada, Moritake Iguchi, Nobutoyo Masunaga, Mitsuru Ishii, Hajime Yamakage, Toru Kusakabe, Akihiro Yasoda, Akira Shimatsu, Kazuhiko Kotani, Noriko Satoh‐Asahara, Mitsuru Abe, Masaharu Akao, Koji Hasegawa   +30 more
doaj   +2 more sources

Emerging Roles for VEGF-D in Human Disease [PDF]

Biomolecules, 2018
Blood vessels and lymphatic vessels are located in many tissues and organs throughout the body, and play important roles in a wide variety of prevalent diseases in humans.
Steven A. Stacker, Marc G. Achen
doaj   +2 more sources

Alginate hydrogels allow for bioactive and sustained release of VEGF-C and VEGF-D for lymphangiogenic therapeutic applications. [PDF]

PLoS ONE, 2017
Lymphatic dysfunction is associated with the progression of many cardiovascular disorders due to their role in maintaining tissue fluid homeostasis.
Kevin T Campbell, Dustin J Hadley, David L Kukis, Eduardo A Silva   +3 more
doaj   +2 more sources

Dysregulated Serum Lipid Metabolism Promotes the Occurrence and Development of Diabetic Retinopathy Associated With Upregulated Circulating Levels of VEGF-A, VEGF-D, and PlGF [PDF]

Frontiers in Medicine, 2021
Purpose: This study aims to explore the correlations of arteriosclerosis-associated plasma indices with various severity levels of diabetic retinopathy (DR) and to test the hypothesis that elevated circulating level of known angiogenic cytokines induced ...
Xinyuan Zhang, Bingjie Qiu, Qiyun Wang, Sobha Sivaprasad, Yanhong Wang, Lin Zhao, Rui Xie, Lei Li, Wenting Kang   +8 more
doaj   +2 more sources

Diagnostic Value of Serum VEGF-D in Lymphangioleiomyomatosis: Results of the First Prospective Study in the Russian Federation [PDF]

Diagnostics
Background/Objectives: Lymphangioleiomyomatosis (LAM) is a rare cystic lung disease for which serum vascular endothelial growth factor D (VEGF-D) is a recommended diagnostic biomarker. Data from the Russian Federation remain limited. We aimed to evaluate
Marina Makarova, Gulsara Baimakanova, Andrey Belevskiy, Anzhelika Chegodar, Airat Bilyalov, Natalia Bodunova   +5 more
doaj   +2 more sources

Elevated VEGF-D Modulates Tumor Inflammation and Reduces the Growth of Carcinogen-Induced Skin Tumors [PDF]

Neoplasia: An International Journal for Oncology Research, 2016
Vascular endothelial growth factor D (VEGF-D) promotes the lymph node metastasis of cancer by inducing the growth of lymphatic vasculature, but its specific roles in tumorigenesis have not been elucidated.
Hanne-Kaisa Honkanen, Valerio Izzi, Tiina Petäistö, Tanja Holopainen, Vanessa Harjunen, Taina Pihlajaniemi, Kari Alitalo, Ritva Heljasvaara   +7 more
doaj   +2 more sources

Expression profiles of VEGF-A, VEGF-D and VEGFR1 are higher in distant metastases than in matched primary high grade epithelial ovarian cancer [PDF]

BMC Cancer, 2019
Background In many malignancies including ovarian cancer, different angiogenic factors have been related to poor prognosis. However, data on their relations to each other or importance as a prognostic factor in ovarian cancer is missing.
Minna Sopo, Maarit Anttila, Kirsi Hämäläinen, Annukka Kivelä, Seppo Ylä-Herttuala, Veli-Matti Kosma, Leea Keski-Nisula, Hanna Sallinen   +7 more
doaj   +2 more sources