Results 11 to 20 of about 241,142 (235)

Curcumin inhibits the lymphangiogenesis of gastric cancer cells by inhibiton of HMGB1/VEGF-D signaling [PDF]

International Journal of Immunopathology and Pharmacology, 2019
Accumulating evidence shows that curcumin exerts antitumor activities in a variety of malignancies. High mobility group box 1 (HMGB1) is associated with vascular endothelial growth factor D (VEGF-D)–induced lymphangiogenesis and tumor metastasis in ...
Wei Da, Jing Zhang, Rui Zhang, Jinshui Zhu   +3 more
doaj   +2 more sources

Pre- and postcapillary pulmonary hypertension in dogs: Circulating biomarkers [PDF]

Open Veterinary Journal, 2022
Background: Pulmonary hypertension (PH) in dogs is a syndrome that could be primary or secondary due to pulmonary disease, pulmonary thromboembolism, heartworm disease, heart failure.
Dmitrij Arkadievich Oleynikov, Ma Yi
doaj   +1 more source

Co-expression of α9β1 integrin and VEGF-D confers lymphatic metastatic ability to a human breast cancer cell line MDA-MB-468LN. [PDF]

PLoS ONE, 2012
INTRODUCTION AND OBJECTIVES: Lymphatic metastasis is a common occurrence in human breast cancer, mechanisms remaining poorly understood. MDA-MB-468LN (468LN), a variant of the MDA-MB-468GFP (468GFP) human breast cancer cell line, produces extensive ...
Mousumi Majumder, Elena Tutunea-Fatan, Xiping Xin, Mauricio Rodriguez-Torres, Jose Torres-Garcia, Ryan Wiebe, Alexander V Timoshenko, Rabindra N Bhattacharjee, Ann F Chambers, Peeyush K Lala   +9 more
doaj   +1 more source

Proteolytic Cleavages in the VEGF Family: Generating Diversity among Angiogenic VEGFs, Essential for the Activation of Lymphangiogenic VEGFs

Biology, 2021
Specific proteolytic cleavages turn on, modify, or turn off the activity of vascular endothelial growth factors (VEGFs). Proteolysis is most prominent among the lymph­angiogenic VEGF-C and VEGF-D, which are synthesized as precursors that need to undergo ...
Jaana Künnapuu, Honey Bokharaie, Michael Jeltsch   +2 more
doaj   +1 more source

VEGF Expression in Colorectal Cancer Metastatic Lymph Nodes: Clinicopathological Correlation and Prognostic Significance

Gastrointestinal Disorders, 2020
Background: Angiogenesis plays an important role in colorectal cancer (CRC) tumorigenesis and metastatic progression. Methods: The present series consisted of CRC lymph node metastasis (LNM) tissue samples from 210 patients.
Inês Mazeda, Sandra F. Martins, Eduardo A. Garcia, Mesquita Rodrigues, Adhemar Longatto   +4 more
doaj   +1 more source

VASCULAR ENDOTHELIAL GROWTH FACTORS IN HEART TRANSPLANT REJECTIONS

Вестник трансплантологии и искусственных органов, 2015
Aim: to determine the clinical significance of vascular endothelial growth factors VEGF-A, VEGF-D, PlGF-1 to assess the risk of cardiovascular complications in heart recipients. Materials and methods.
O. P. Shevchenko, E. A. Stakhanova, A. O. Shevchenko, N. P. Mogeiko, O. E. Gichkun   +4 more
doaj   +1 more source

The association of alternate VEGF ligands with resistance to anti-VEGF therapy in metastatic colorectal cancer. [PDF]

PLoS ONE, 2013
BACKGROUND:Circulating angiogenic factors are altered in patients with mCRC receiving bevacizumab. Evaluation of alterations in levels of VEGF ligands may provide insights into possible resistance mechanisms. METHODS:PlGF, VEGF-A, VEGF-C, and VEGF-D were
Christopher H Lieu, Hai Tran, Zhi-Qin Jiang, Muling Mao, Michael J Overman, E Lin, Cathy Eng, Jeffrey Morris, Lee Ellis, John V Heymach, Scott Kopetz   +10 more
doaj   +1 more source

Differential receptor binding and regulatory mechanisms for the lymphangiogenic growth factors VEGF-C and VEGF-D [PDF]

, 2016
VEGF-C and VEGF-D are secreted glycoproteins that induce angiogenesis and lymphangiogenesis in cancer, thereby promoting tumor growth and spread. They exhibit structural homology and activate VEGFR-2 and VEGFR-3, receptors on endothelial cells that ...
Achen, Marc G, Davydova, Natalia, Harris, Nicole C, Ishaq, Musarat, Karnezis, Tara, Paquet-Fifield, Sophie, Roufail, Sally, Stacker, Steven A, Streltsov, Victor A, Williams, Steven P   +9 more
core   +1 more source

Early Changes of VEGF Levels After Zoledronic Acid in Women With Postmenopausal Osteoporosis: A Potential Role of Vitamin D

Frontiers in Medicine, 2021
Zoledronic acid (Zol) is a widely used intravenous aminobisphosphonate to treat both benign and malignant skeletal diseases, and bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a serious side effect whose pathophysiology remains poorly ...
Federica Bellone, Antonino Catalano, Angelo Ruggero Sottile, Agostino Gaudio, Saverio Loddo, Francesco Corica, Nunziata Morabito   +6 more
doaj   +1 more source

Clinical significance of VEGF-A, -C and -D expression in esophageal malignancies [PDF]

, 2005
Vascular endothelial growth factors ( VEGF)- A, - C and - D are members of the proangiogenic VEGF family of glycoproteins. VEGF-A is known to be the most important angiogenic factor under physiological and pathological conditions, while VEGF-C and VEGF-D
Ahn MJ, Baatar D, Banks RE, Berse B, Boucher Y, Coia LR, Dirix LY, Du JR, Gu ZP, Guo WZ, Hefler L, Hickey K, Hironaka S, Isaka N, Ishikawa M, Karpanen T, Kato H, Kitadai Y, Kitamura K, Koide N, Koukourakis MI, Kukk E, Kumar H, Lackey VL, Lewis CE, Li Z, Maniwa Y, Millikan KW, Mobius C, Nagata J, Nguyen M, Noguchi T, Nor JE, Ohtsu A, Roberts WG, Rockwell S, Roder JD, Salven P, Shih CH, Spence GM, Suit HD, Theunissen PH, Uchida S, Vogel SB, Wallner G, Weingartner K, Yamamoto Y, Yang B, Yeo KT   +48 more
core   +1 more source