VEGF-A, VEGF-C, and VEGF-D in Colorectal Cancer Progression
Neoplasia: An International Journal for Oncology Research, 2001 We aimed to assess the relationship of the angiogenic cytokines VEGF-A, VEGF-C, and VEGF-D and their receptors VEGFR-2 and VEGFR-3 in the adenomacarcinoma sequence and in metastatic spread of colorectal cancer (CRC).
Mark L. George +6 more
doaj +4 more sources
VEGF-C and VEGF-D Blockade Inhibits Inflammatory Skin Carcinogenesis [PDF]
Cancer Research, 2013 Abstract VEGF-C and VEGF-D were identified as lymphangiogenic growth factors and later shown to promote tumor metastasis, but their effects on carcinogenesis are poorly understood. Here, we have studied the effects of VEGF-C and VEGF-D on tumor development in the murine multistep chemical carcinogenesis model of squamous cell ...
Alitalo AK +8 more
core +6 more sources
VEGF-D promotes pulmonary oedema in hyperoxic acute lung injury. [PDF]
J Pathol, 2016 AbstractLeakage of fluid from blood vessels, leading to oedema, is a key feature of many diseases including hyperoxic acute lung injury (HALI), which can occur when patients are ventilated with high concentrations of oxygen (hyperoxia). The molecular mechanisms driving vascular leak and oedema in HALI are poorly understood.
Sato T +13 more
europepmc +8 more sources
Diagnostic performance of VEGF-D for lymphangioleiomyomatosis: a meta-analysis. [PDF]
J Bras Pneumol, 2022 Objective: VEGF-D is a potential biomarker for lymphangioleiomyomatosis (LAM); however, its diagnostic performance has yet to be systematically studied. Methods: We searched PubMed, EMBASE, Scopus, Web of Science, and Cochrane Library to identify primary studies on VEGF-D in relation to the diagnosis of LAM.
Li M +5 more
europepmc +5 more sources
Pre- and postcapillary pulmonary hypertension in dogs: Circulating biomarkers [PDF]
Open Veterinary Journal, 2022 Background: Pulmonary hypertension (PH) in dogs is a syndrome that could be primary or secondary due to pulmonary disease, pulmonary thromboembolism, heartworm disease, heart failure.
Dmitrij Arkadievich Oleynikov, Ma Yi
doaj +1 more source
Vascular Endothelial Growth Factor-D (VEGF-D): An Angiogenesis Bypass in Malignant Tumors. [PDF]
Int J Mol Sci, 2023 Vascular endothelial growth factors (VEGFs) are the key regulators of vasculogenesis in normal and oncological development. VEGF-A is the most studied angiogenic factor secreted by malignant tumor cells under hypoxic and inflammatory stress, which made ...
Bokhari SMZ, Hamar P.
europepmc +2 more sources
VEGF-D: a novel biomarker for detection of COVID-19 progression. [PDF]
Crit Care, 2020 Kong Y +5 more
europepmc +5 more sources
VEGF-A/VEGF-B/VEGF-C expressions in non-hereditary, non-metastatic phaeochromocytoma. [PDF]
, 2021 Vascular endothelial growth factor (VEGF) is important in pathogenesis of different cancers. The aim of this study is to investigate the relationships between different VEGFs and clinicopathological factors in patients with phaeochromocytomas.
Pillai, Suja +5 more
core +3 more sources
Co-expression of α9β1 integrin and VEGF-D confers lymphatic metastatic ability to a human breast cancer cell line MDA-MB-468LN. [PDF]
PLoS ONE, 2012 INTRODUCTION AND OBJECTIVES: Lymphatic metastasis is a common occurrence in human breast cancer, mechanisms remaining poorly understood. MDA-MB-468LN (468LN), a variant of the MDA-MB-468GFP (468GFP) human breast cancer cell line, produces extensive ...
Mousumi Majumder +9 more
doaj +1 more source
Biology, 2021 Specific proteolytic cleavages turn on, modify, or turn off the activity of vascular endothelial growth factors (VEGFs). Proteolysis is most prominent among the lymphangiogenic VEGF-C and VEGF-D, which are synthesized as precursors that need to undergo ...
Jaana Künnapuu +2 more
doaj +1 more source