Results 181 to 190 of about 20,098,805 (300)

Thrombospondin-4 drives lymphangiogenesis through cooperation with VEGF-C in human bladder cancer. [PDF]

Int J Med Sci
Hwang TI, Peng PW, Chi MS, Chou KY, Tsai TF, Ho CY, Chang AC.   +6 more
europepmc   +1 more source

Coexpression of TLR9 and VEGF-C is associated with lymphatic metastasis in prostate cancer. [PDF]

Asian J Androl, 2022
Zeng XZ, Huang ZS, Fang HP, Wu JY, Huang QX, Zhuang CB, Zhou J, Di JM.   +7 more
europepmc   +1 more source

Lactate Signal: Modulator of Cellular Energy Production and Anabolism

Advanced Science, EarlyView.
Compartmentalized lactate signaling provides a spatial framework for understanding how lactate‐rich states are generated, transported, sensed, and translated into biological outputs. This Review integrates extracellular, cytosolic, mitochondrial‐associated, and nuclear lactate mechanisms to explain how lactate shapes metabolic adaptation, immune ...
Han Wang, Si‐Yuan Yang, Wei Xu
wiley   +1 more source

SPIO-enhanced MRI for differentiating metastatic from reactive hyperplastic lymph nodes in breast cancer: diagnostic performance and association with VEGF-C expression. [PDF]

Front Med (Lausanne)
Wu T, Wu A, Xiong H, Deng J, Zhang Z, Gong D, Luo J, Wu D.   +7 more
europepmc   +1 more source

3D Bioprinted Blood–Brain–Tumor Barrier Spheroid‐Based In Situ Evaluation of Anticancer Compounds Against Glioblastoma: ROS‐Producing Ruthenium as a Potential Therapeutic Candidate

Advanced Science, EarlyView.
The blood–brain–tumor barrier (BBTB) penetration by anticancer drugs and their effects on glioblastoma (GBM) is assessed using 3D bioprinted‐spheroids. Anticancer drug‐induced U‐87 MG cell death is quantified through in situ imaging of spheroids using a cancer cell death probe. The Ru compound, a partial P‐gp substrate, induces greater tumor‐cell death
Hyunjung Lee, Chan Ho Jeon, Doyun Kim, Minjae Lee, Minji Kwon, Joon Myong Song   +5 more
wiley   +1 more source

RIP1 Contributes to Colorectal Cancer Progression and Lymphatic Remodeling in Association With VEGF-C/NF-κB Pathway. [PDF]

FASEB Bioadv
Li M, Li H.
europepmc   +1 more source

Visfatin upregulates VEGF-C expression and lymphangiogenesis in esophageal cancer by activating MEK1/2-ERK and NF-κB signaling. [PDF]

Aging (Albany NY), 2023
Huang CL, Achudhan D, Liu PI, Lin YY, Liu SC, Guo JH, Liu CL, Wu CY, Wang SW, Tang CH.   +9 more
europepmc   +1 more source

Meningeal Lymphatic LTBR Deficiency Links Spinal Cord Injury to Secondary Brain Pathology

Advanced Science, EarlyView.
Spinal cord injury (SCI) induces remote brain alterations beyond the injured spinal cord. This study links dysfunction of meningeal lymphatic vessels (mLVs) to neuroinflammation and neuronal injury after SCI. LTBR‐mediated lymphatic restoration improves meningeal lymphatic integrity and neurological outcomes, highlighting LTBR as a potential regulator ...
Yi Chen, Yu Tang, Chengpeng Hu, Xiaoyan Duan, LingXia Min, Boya Cong, Chao Ma, Mingliang Tan, Ya Luo, Pengfei Wei, Minpeng Xu, Zhou Feng, Jingming Hou   +12 more
wiley   +1 more source

AXL promotes lymphangiogenesis by amplifying VEGF-C-mediated AKT pathway. [PDF]

Cell Mol Life Sci
Pirson S, Gautier-Isola M, Baudin L, Rouaud L, Vanwynsberghe A, Deroye J, Bekisz S, Gucciardo F, Lebeau A, Buntinx F, Ivanova E, Staumont B, Blacher S, Gilles C, Noël A.   +14 more
europepmc   +1 more source

Tumor‐Intrinsic HEXB Drives Endothelial‐To‐Mesenchymal Transition and Confers Resistance to Anti‐Angiogenic Therapy in Glioblastoma

Advanced Science, EarlyView.
This study elucidates how glioblastoma tumors develop resistance to anti‐VEGF therapy through endothelial‐to‐mesenchymal transition (Endo‐MT). The researchers identify a novel signaling pathway where tumor‐derived HEXB stabilizes HSP60 to drive this vascular reprogramming.
Tianqi Liu, Xin Chen, Tao Sun, Jianqi Wu, Haixu Yan, Xing Liu, Hongda Lin, Xiangyu Wang, Ziao Xiao, Yang Xu, Qiang Fu, Peng Cheng, Wen Cheng, Anhua Wu   +13 more
wiley   +1 more source