Results 191 to 200 of about 285,367 (303)

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source

VEGF-C propagates 'onward' colorectal cancer metastasis from liver to lung. [PDF]

Br J Cancer
Poghosyan S, Frenkel N, van den Bent L, Raats D, Spaapen T, Laoukili J, Borel Rinkes I, Kranenburg O, Hagendoorn J.   +8 more
europepmc   +1 more source

IL-1RA inhibits esophageal carcinogenesis and lymphangiogenesis via downregulating VEGF-C and MMP9.

Funct Integr Genomics, 2023
Shen Z, Zhang P, Zhang W, Luo F, Xu H, Chen S, Kang M.   +6 more
europepmc   +1 more source

ANRIL promotes the regulation of colorectal cancer on lymphatic endothelial cells via VEGF-C and is the key target for Pien Tze Huang to inhibit cancer metastasis. [PDF]

Cancer Gene Ther, 2023
Huang B, Lu Y, Ni Z, Liu J, He Y, An H, Ye F, Shen J, Lin M, Chen Y, Lin J.   +10 more
europepmc   +1 more source

Combating VEGFA‐siRNA‐Induced Metabolic Reprogramming via Glucose Utilization Deprivation

Advanced Science, EarlyView.
An ionizable lipid nanoparticle co‐delivers VEGFA siRNA and glucose oxidase to tumors to counteract VEGFA knockdown‐induced, glutamine‐driven metabolic compensation. Enzymatic glucose consumption reverses the adaptive pathways and restores metabolism toward baseline, thereby sensitizing tumors to therapy.
Lulu Zheng, Shuai Guo, Yingjixing Luo, Pengfei Wu, Haiyin Yang, Yingqiu Xie, Yuchuan Fan, Qing Liu, Bo Hu, Jia Huang, Yuanyu Huang   +10 more
wiley   +1 more source

VEGF-C and Lymphatic Vessel Density in Tumor Tissue of Gastric Cancer: Correlations with Pathoclinical Features and Prognosis. [PDF]

Cancers (Basel)
Szajewski M, Ciesielski M, Pęksa R, Kurek P, Stańczak M, Walczak J, Zieliński J, Kruszewski WJ.   +7 more
europepmc   +1 more source

VEGF-C serum level is associated with response to bevacizumab maintenance therapy in primary ovarian cancer patients. [PDF]

PLoS One, 2022
Ding Y, Oliveira-Ferrer L, Vettorazzi E, Legler K, Milde-Langosch K, Woelber L, Jaeger A, Prieske K, Mueller V, Schmalfeldt B, Kuerti S.   +10 more
europepmc   +1 more source

A NeuroD1 AAV‐Based Gene Therapy for Functional Brain Repair in Alzheimer's Disease‐Like Non‐Human Primate Model

Advanced Science, EarlyView.
This study tests NeuroD1 AAV‐based gene therapy in a non‐human primate Alzheimer's disease model. The therapy prevents neuronal damage, inhibits hippocampal atrophy, and reduces neuroinflammation. It also repairs vascular and blood‐brain barrier damage, restores cerebrospinal fluid biomarkers, enhances hippocampal glucose metabolism, and improves ...
Zhouquan Jiang, Yongpeng Qin, Bin Luo, Fan Bai, Jiangyue Liu, Long Ma, Shu He, Rongjie Chen, Yuchen Wang, Shanggong Liu, Ying Sun, Yi Chen, Shuo Zhang, Jiaqi Liang, Feng Liao, Huiyi Wei, Junjie Wei, Lu Wang, Hao Xu, Zheng Wu, Gong Chen, Wenliang Lei   +21 more
wiley   +1 more source

Overestimation of clinical N-staging in microsatellite instable gastric cancers is associated with VEGF-C signaling and CD8+ T-cell dynamics. [PDF]

Oncologist
Tsai CY, Tai TS, Huang SC, Chen TH, Hsu JT, Yeh CN, Lai YC, Lin G, Yeh TS.   +8 more
europepmc   +1 more source

BANCR positively regulates the HIF-1α/VEGF-C/VEGFR-3 pathway in a hypoxic microenvironment to promote lymphangiogenesis in pancreatic cancer cells. [PDF]

Oncol Lett, 2022
Hao S, Han W, Ji Y, Sun H, Shi H, Ma J, Yip J, Ding Y.   +7 more
europepmc   +1 more source