Results 251 to 260 of about 20,098,805 (300)

Comparison of VEGF, VEGF-B, VEGF-C and Ang-1 mRNA Regulation by Serum, Growth Factors, Oncoproteins and Hypoxia

Oncogene, 1997
The vascular endothelial growth factor (VEGF) family has recently been expanded by the isolation of two additional growth factors, VEGF-B and VEGF-C. Here we compare the regulation of steady-state levels of VEGF, VEGF-B and VEGF-C mRNAs in cultured cells
Juha Klefström, Kari Alitalo, Karri Paavonen   +2 more
exaly   +2 more sources

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VEGF-C shines a light on brain tumours

Nature Reviews Immunology, 2020
VEGF-C enhances T cell priming against brain tumours and improves the efficacy of immune checkpoint blockade in a model of glioblastoma.
openaire   +2 more sources

Hyperplasia of Lymphatic Vessels in VEGF-C Transgenic Mice

Science, 1997
No growth factors specific for the lymphatic vascular system have yet been described. Vascular endothelial growth factor (VEGF) regulates vascular permeability and angiogenesis, but does not promote lymphangiogenesis. Overexpression of VEGF-C, a ligand of the VEGF receptors VEGFR-3 and VEGFR-2, in the skin of transgenic mice resulted in lymphatic, but ...
Jeltsch, M., Kaipainen, A., Joukov, V., Meng, X., Lakso, M., Rauvala, H., Swartz, M. A., Fukumura, D., Jain, R. K., Alitalo, K.   +9 more
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VEGF-C expression in breast cancer: Clinical importance

Advances in Therapy, 2005
It is well known that angiogenesis and lymphangiogenesis play important roles in tumor occurrence and progression. The vascular endothelial growth factor (VEGF) family is the most important family of proteins involved in angiogenesis, and VEGF-C is the most important molecule in lymphangiogenesis.
Yavuz S., Paydas S., Disel U., Zorludemir S., Erdogan S.   +4 more
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Quantification of VEGF‐C expression in canine mammary tumours

Australian Veterinary Journal, 2008
Background  Tumours release angiogenic factors such as vascular endothelium growth factor (VEGF), which induces growth of a capillary network around the tumour. Elevated concentrations of VEGF have been reported in human mammary gland tumours.Methods  To evaluate the expression of VEGF‐C mRNA in canine mammary tissue, 38 mammary gland tumours ...
C, Qiu, D D, Lin, H H, Wang, C H, Qiao, J, Wang, T, Zhang   +5 more
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VEGF-C: putting the ‘lymph’ back in lymphoma?

Leukemia & Lymphoma, 2009
In this issue of Leukemia & Lymphoma[1], Paydas et al. report significantly shorter median overall survival in patients with aggressive non-Hodgkin lymphoma whose lymphoma cells produce immunohisto...
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VEGF-C/VEGFRS and Cancer Metastasis

2006
Vascular endothelial growth factor C (VEGF-C) is the only factor known causing lymphangiogenesis. We report herein the review of recent experimental studies on VEGF family and their receptors and the molecular mechanisms of the lymphangiogenesis in cancer.
Yutaka Yonemura, Yoshio Endou, Takuma Sasaki, Kazuo Sugiyama, Tetumouri Yamashima, Taina Partaneri, Kari Alitalo   +6 more
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Functional interaction of VEGF‐C and VEGF‐D with neuropilin receptors

The FASEB Journal, 2006
ABSTRACT Lymphatic vascular development is regulated by vascular endothelial growth factor receptor‐3 (VEGFR‐3), which is activated by its ligands VEGF‐C and VEGF‐D. Neuropilin‐2 (NP2), known to be involved in neuronal development, has also been implicated to play a role in lymphangiogenesis. We aimed to elucidate
KÄRPÄNEN T, HECKMAN CA, KESKITALO S, JELTSCH M, OLLILA H, NEUFELD G, TAMAGNONE, Luca, ALITALO K.   +7 more
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Expression and localization of VEGF‐C and VEGFR‐3 in glioblastomas and haemangioblastomas

The Journal of Pathology, 2006
AbstractPrimary human brain tumours account for approximately 2% of all cancers. High levels of expression of vascular endothelial growth factor‐A (VEGF‐A), a potent angiogenic factor, are linked to poor prognosis. In contrast, the potential role in human brain tumour biology of newer VEGF family members, VEGF‐C and VEGF‐D, both of which are ...
Jenny, Benoît John, Harrison, J. A., Baetens, D., Tille, J. C., Burkhardt, Karim, Mottaz, H., Kiss, Jozsef Zoltan, Dietrich, Pierre-Yves, De Tribolet, Nicolas, Pizzolato, G. P., Pepper, Michael Sean   +10 more
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Plasmin activates VEGF-C and VEGF-D

International Congress Series, 2004
Abstract Angiogenesis and lymphangiogenesis (growth of lymphatic vessels) are guided by members of the vascular endothelial growth factor (VEGF) family of secreted glycoproteins. In particular, VEGF-C and VEGF-D promote lymphangiogenesis as demonstrated in transgenic animal models and gene delivery studies.
Bradley K McColl, Megan E Baldwin, Sally Roufail, Craig Freeman, Kari Alitalo, Steven A Stacker, Marc G Achen   +6 more
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