Results 261 to 270 of about 285,367 (303)

Current biology of VEGF-B and VEGF-C

Current Opinion in Biotechnology, 1999
Endothelial growth factors and their receptors may provide important therapeutic tools for the treatment of pathological conditions characterised by defective or aberrant angiogenesis. Vascular endothelial growth factor (VEGF) is pivotal for vasculogenesis and for angiogenesis in normal and pathological conditions.
B, Olofsson, M, Jeltsch, U, Eriksson, K, Alitalo   +3 more
openaire   +2 more sources

VEGF-C expression in breast cancer: Clinical importance

Advances in Therapy, 2005
It is well known that angiogenesis and lymphangiogenesis play important roles in tumor occurrence and progression. The vascular endothelial growth factor (VEGF) family is the most important family of proteins involved in angiogenesis, and VEGF-C is the most important molecule in lymphangiogenesis.
Yavuz S., Paydas S., Disel U., Zorludemir S., Erdogan S.   +4 more
openaire   +2 more sources

Vascular endothelial growth factors VEGF‐B and VEGF‐C

Journal of Cellular Physiology, 1997
Vascular endothelial growth factor, which was idenheart cDNA library, respectively, by using a serendipitously found partial mouse cDNA clone as a probe tified almost 10 years ago, has so far been considered as the only growth factor relatively specific for endothelial (20,24).
V, Joukov, A, Kaipainen, M, Jeltsch, K, Pajusola, B, Olofsson, V, Kumar, U, Eriksson, K, Alitalo   +7 more
openaire   +2 more sources

Plasmin activates VEGF-C and VEGF-D

International Congress Series, 2004
Abstract Angiogenesis and lymphangiogenesis (growth of lymphatic vessels) are guided by members of the vascular endothelial growth factor (VEGF) family of secreted glycoproteins. In particular, VEGF-C and VEGF-D promote lymphangiogenesis as demonstrated in transgenic animal models and gene delivery studies.
Bradley K McColl, Megan E Baldwin, Sally Roufail, Craig Freeman, Kari Alitalo, Steven A Stacker, Marc G Achen   +6 more
openaire   +1 more source

VEGF-C shines a light on brain tumours

Nature Reviews Immunology, 2020
VEGF-C enhances T cell priming against brain tumours and improves the efficacy of immune checkpoint blockade in a model of glioblastoma.
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Therapeutic lymphangiogenesis using stem cell and VEGF-C hydrogel

Biomaterials, 2011
Lymphedema is a manifestation of lymphatic system insufficiency. It arises from primary lymphatic dysplasia or secondary obliteration after lymph node dissection or irradiation. Although improvement of swelling can be achieved by comprehensive non-operative therapy, treatment of this condition requires lifelong care and good compliance.
Ji Hye, Hwang, In Gul, Kim, Ji Young, Lee, Shuyu, Piao, David S, Lee, Tae Seung, Lee, Jeong Chan, Ra, Ji Youl, Lee   +7 more
openaire   +2 more sources

VEGF-C/VEGFRS and Cancer Metastasis

2006
Vascular endothelial growth factor C (VEGF-C) is the only factor known causing lymphangiogenesis. We report herein the review of recent experimental studies on VEGF family and their receptors and the molecular mechanisms of the lymphangiogenesis in cancer.
Yutaka Yonemura, Yoshio Endou, Takuma Sasaki, Kazuo Sugiyama, Tetumouri Yamashima, Taina Partaneri, Kari Alitalo   +6 more
openaire   +1 more source

VEGF-C mediates cyclic pressure-induced endothelial cell proliferation

Physiological Genomics, 2002
Mechanical forces modulate endothelial cell functions through several mechanisms including regulation of gene transcription. In the present study, gene transcription by human umbilical vein endothelial cells (HUVEC) either maintained under control pressure (that is, standard cell culture conditions equivalent to 0.15 mmHg sustained hydrostatic pressure)
Hainsworth Y, Shin, Michael L, Smith, Karen J, Toy, P Mickey, Williams, Rena, Bizios, Mary E, Gerritsen   +5 more
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Quantification of VEGF‐C expression in canine mammary tumours

Australian Veterinary Journal, 2008
Background  Tumours release angiogenic factors such as vascular endothelium growth factor (VEGF), which induces growth of a capillary network around the tumour. Elevated concentrations of VEGF have been reported in human mammary gland tumours.Methods  To evaluate the expression of VEGF‐C mRNA in canine mammary tissue, 38 mammary gland tumours ...
C, Qiu, D D, Lin, H H, Wang, C H, Qiao, J, Wang, T, Zhang   +5 more
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Hyperplasia of Lymphatic Vessels in VEGF-C Transgenic Mice

Science, 1997
No growth factors specific for the lymphatic vascular system have yet been described. Vascular endothelial growth factor (VEGF) regulates vascular permeability and angiogenesis, but does not promote lymphangiogenesis. Overexpression of VEGF-C, a ligand of the VEGF receptors VEGFR-3 and VEGFR-2, in the skin of transgenic mice resulted in lymphatic, but ...
M, Jeltsch, A, Kaipainen, V, Joukov, X, Meng, M, Lakso, H, Rauvala, M, Swartz, D, Fukumura, R K, Jain, K, Alitalo   +9 more
openaire   +2 more sources