Results 81 to 90 of about 285,367 (303)

CD146 is required for VEGF-C-induced lymphatic sprouting during lymphangiogenesis

Scientific Reports, 2017
VEGF-C is essential for lymphangiogenesis during development and tumor progression. VEGFR-3 is the well-known cognate receptor of VEGF-C to regulate lymphatic migration and proliferation, but the receptor of VEGF-C in regulating lymphatic sprouting, the ...
Huiwen Yan, Chunxia Zhang, Zhaoqing Wang, Tao Tu, Hongxia Duan, Yongting Luo, Jing Feng, Feng Liu, Xiyun Yan   +8 more
doaj   +1 more source

Lymphendothel in terminaler Herzinsuffizienz und nach Herz- und Lungentransplantation [PDF]

, 2017
The lymphatic endothelium is relevant for the pathogenesis of various cardiac and pulmonary diseases. However, the knowledge about the functions and role of lymphatic endothelium in the setting of transplantation is very limited.
Dashkevich, Alexey
core  

Adventitial lymphatic capillary expansion impacts on plaque T cell accumulation in atherosclerosis [PDF]

, 2017
During plaque progression, inflammatory cells progressively accumulate in the adventitia, paralleled by an increased presence of leaky vasa vasorum. We here show that next to vasa vasorum, also the adventitial lymphatic capillary bed is expanding during ...
Alitalo, Kari, Anisimov, Andrey, Biessen, Erik A. L., Daissormont, Isabelle T. M. N., Gijbels, Marion, Heeneman, Sylvia, Lindeman, Jan H. N., Nurmi, Harri, Otten, Jeroen J. T., Rademakers, Timo, Schober, Andreas, Theelen, Thomas L., Theodorou, Kosta, van der Vorst, Emiel P. C.   +13 more
core   +1 more source

An Important Role of VEGF-C in Promoting Lymphedema Development [PDF]

Journal of Investigative Dermatology, 2017
Secondary lymphedema is a common complication after cancer treatment, but the pathomechanisms underlying the disease remain unclear. Using a mouse tail lymphedema model, we found an increase in local and systemic levels of the lymphangiogenic factor vascular endothelial growth factor (VEGF)-C and identified CD68+ macrophages as a cellular source ...
Gousopoulos, Epameinondas, Proulx, Steven T, Bachmann, Samia B, Dieterich, Lothar C, Scholl, Jeannette, Karaman, Sinem, Bianchi, Roberta, Detmar, Michael   +7 more
openaire   +4 more sources

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Expression of vascular endothelial growth factor (VEGF)-C in preoperative biopsy specimens and metastatic foci of regional lymph nodes in submucosal gastric carcinoma

World Journal of Surgical Oncology, 2005
Background Vascular endothelial growth factor (VEGF)-C is implicated in lymphangiogenesis, however the exact role of VEGF-C in promoting lymphatic spread of cancer cells remains largely unknown.
Kazama Shinsuke, Kitayama Joji, Ishikawa Makoto, Nagawa Hirokazu   +3 more
doaj   +1 more source

Engineering Blood and Lymphatic Microvascular Networks in Fibrin Matrices [PDF]

, 2017
Vascular network engineering is essential for nutrient delivery to tissue-engineered constructs and, consequently, their survival. In addition, the functionality of tissues also depends on tissue drainage and immune cell accessibility, which are the main
Hasenberg, Tobias, Holnthoner, Wolfgang, Knezevic, Lea, Marx, Uwe, Mühleder, Severin, Priglinger, Eleni, Redl, Heinz, Schaupper, Mira, Schimek, Katharina   +8 more
core   +1 more source

Arterial Delivery of VEGF-C Stabilizes Atherosclerotic Lesions [PDF]

Circulation Research, 2021
Carlos Silvestre-Roig, Patricia Lemnitzer, Julie Gall, Simon Schwager, Albulena Toska, Laurent Yvan-Charvet, Michael Detmar, Oliver Soehnlein   +7 more
openaire   +2 more sources

Marked Long‐Term Improvement in Lung Function in Melanoma Differentiation–Associated Protein 5 Antibody–Positive Dermatomyositis Patients: Experience of a Single‐Center Longitudinal Cohort in North America

Arthritis Care &Research, EarlyView.
Objective The objective of this study was to describe the longitudinal disease course and pulmonary outcomes of North American patients with melanoma differentiation–associated protein 5 (MDA5) antibody–associated dermatomyositis (DM). Methods Thirty patients with MDA5 antibody–associated DM were identified in a single‐center longitudinal cohort of 352
Jenice X. Cheah, Sangmee S. Bae, Tiffany De Leon, Yuna Lee, Rong Guo, David Elashoff, Jennifer Wang, Ani Shahbazian, Christina Charles‐Schoeman   +8 more
wiley   +1 more source

Hypoxia inducible factor-1α correlates with vascular endothelial growth factor A and C indicating worse prognosis in clear cell renal cell carcinoma [PDF]

, 2009
Background The role of angiogenesis in the pathogenesis of renal cell carcinoma is well recognized, however, the influence of tumor cells in this activity has not yet been fully clarified.
Gordana Đorđević, Koviljka Matušan-Ilijaš, Emina Babarović, Ita Hadžisejdić, Maja Grahovac, Blaženka Grahovac, Nives Jonjić   +6 more
core   +2 more sources