Results 91 to 100 of about 413,657 (289)

A U‐shaped Microfluidic Platform for Culturing Vascularized Colorectal Cancer Spheroids Reveals Tumor–Endothelial Crosstalk and Invasion‐Associated Remodeling

open access: yesAdvanced Materials Technologies, EarlyView.
A closed U‐shaped microfluidic platform symmetrically embeds a single, size‐controlled HT29 colorectal cancer spheroid within a GFP‐HUVEC‐laden fibrin matrix. HT29 spheroids are associated with hyper‐branched endothelial network remodeling, while vascularized co‐culture is accompanied by anisotropic protrusive growth and EMT‐like marker changes in the ...
G. Cretti   +4 more
wiley   +1 more source

Ramucirumab, A Second-Line Option For Patients With Hepatocellular Carcinoma: A Review Of The Evidence

open access: yesCancer Management and Research, 2020
Emmanuele De Luca,1,2,* Donatella Marino,1,2,* Massimo Di Maio1,2 1Department of Oncology, University of Turin, Torino, Italy; 2Division of Medical Oncology, Ordine Mauriziano Hospital, Torino, Italy*These authors contributed equally to this ...
De Luca E, Marino D, Di Maio M
doaj  

Growth Promoting Effect of Vacuum Sealing Drainage in the Healing Processes of Diabetic Foot Ulcers

open access: yesTherapeutics and Clinical Risk Management, 2021
Hui Yang,* Lan Liu,* Gai Li, Yinchen Chen, Dong Jiang, Wei Wang, Tianyuan Wang, Jinshan Sun, Jianfang Che, Dongmei Gu, Meng Lu, Aiping Wang Department of Endocrinology, The Air Force Hospital from Eastern Theater of PLA, Nanjing 210029, People’s ...
Yang H   +11 more
doaj  

Inhibition of IGFBP4 in Granulosa Cells Improves Reproductive Performance and Maintains Fertility With Age via YAP Signaling

open access: yesAdvanced Science, EarlyView.
IGFBP4 is upregulated in granulosa cells of aged ovaries across monkeys, mice, and humans. It inhibits YAP signaling, thereby suppressing cell proliferation and contributing to follicular dysfunction. Deletion of Igfbp4 in granulosa cells enhances ovulatory output, improves hormone profiles, and reproductive performance in aged female mice, suggesting ...
Qianhui Hu   +8 more
wiley   +1 more source

Nuevas contribuciones al estudio de los efectores inmunológicos inducidos con la inmunoterapia activa específica CIGB-247

open access: yesAnales de la Academia de Ciencias de Cuba, 2022
Objetivos. Esta investigación tiene como objetivo estudiar los efectores inmunológicos que se inducen en los pacientes inmunizados con el CIGB-247, que incluyen elementos humo - rales y celulares.
Javier Sánchez Ramírez   +11 more
doaj  

Modulation of miR‐23b Wnt/β‐catenin Axis Strengthens Endothelial Barrier Properties

open access: yesAdvanced Science, EarlyView.
Early blood‐brain barrier (BBB) disruption contributes to stroke and CNS disease pathology. miR‐23b was identified as a regulator of BBB integrity in brain endothelial cells. Inhibition of miR‐23b enhanced barrier‐associated properties, promoted repair‐related signaling, and reduced BBB leakage in experimental stroke models, supporting further ...
Victor Anthony Martinez   +16 more
wiley   +1 more source

Study of biomarkers p53, Ki-67, Bcl-2, and VEGF in pterygium

open access: yesIndian Journal of Ophthalmology
Purpose: To study the biomarkers present in primary pterygium samples of patients of Indian ethnicity and compare it with the samples obtained from the unaffected conjunctiva of the same eye.
Shilpa Ghosh   +4 more
doaj   +1 more source

Aptamer‐Engineered Liposomal Platform Enables in Situ cDC1 Vaccination to Potentiate Immunotherapy in Prostate Cancer

open access: yesAdvanced Science, EarlyView.
Prostate cancer is immunologically ‘cold’, with scarce, dysfunctional type 1 conventional dendritic cells (cDC1s) that limit T cell priming. We introduce an aptamer‐targeted liposomedelivering FMS‐like tyrosine kinase 3 ligand (Flt3L) and chlorin e6 (Ce6). Ultrasound induces antigen release and cDC1s recruitment, creating an in situ cDC1 vaccine.
Jiayi Wang   +8 more
wiley   +1 more source

VEGF-A splicing patterns in kidney tissue obtained from healthy mice and humans.

open access: yes, 2016
The VEGF-A 121, 165, and 189 isoforms were measured in kidney biopsies obtained from healthy human subjects, and the corresponding VEGF-A isoforms (VEGF-A 120, 164, and 188, respectively) were measured in kidney tissue and obtained from healthy mice ...
H. J. Baelde (3105789)   +4 more
core   +1 more source

Modern aspects of the pathogenesis, diagnosis and treatment of diabetic retinopathy

open access: yesКлинический разбор в общей медицине
The article discusses current ideas about the pathogenesis, risk factors, and new methods of diagnosis and treatment of diabetic retinopathy. This disease is a specific microvascular ocular complication of diabetes mellitus and is part of the group of ...
Elmaz Z. Kayalieva   +2 more
doaj   +1 more source

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