Results 111 to 120 of about 384,919 (304)

Chromosomal Instability Drives Glioblastoma Heterogeneity and Therapeutic Opportunities

Advanced Science, EarlyView.
ABSTRACT Glioblastoma, the most aggressive and lethal form of brain cancer, is defined by profound genomic instability, with Chromosomal Instability (CIN) playing a central role in driving tumor progression, therapy resistance, and poor prognosis. CIN is characterized by numerical and structural alterations, is driven by mechanisms such as mitotic ...
Amarnath Pal, Milan Patra, Rianita Mondal, Shubhasis Haldar   +3 more
wiley   +1 more source

VEGF-C is differentially expressed between lymphangiogenic and non-lymphangiogenic NSCLC cell lines.

, 2016
(A) Microarray results showing genes differentially expressed between lymphangiogenic (Calu-1, HCC827, HCC461, H1993, and H2122) and non-lymphangiogenic (Calu-3, H1155, H1975, and H2073) cells.
John D. Minna (158214), Robert C. Sibley (3182082), Michael T. Dellinger (337877), Erin Regan (3182085), Asitha Silva (3182088), Bercin Kutluk Cenik (3182079), Luc Girard (67129)   +6 more
core   +1 more source

Perivascular Matrix Densification Dysregulates Angiogenesis and Activates Pro‐Inflammatory Endothelial Cells

Advanced Science, EarlyView.
Perivascular matrix densification promotes the emergence of aberrant endothelial tip cells (ATECs) that invade and persist within fibrotic microenvironments. Using in vivo lineage tracing and a human microvessel model, this study shows that fibrous matrix cues destabilize VE‐cadherin–mediated junctions to gate TGF‐β signaling, inducing a pro ...
Jingyi Xia, William Y. Wang, Kyle A. Jacobs, Kairav Maniar, Daphne Lin, Evan H. Jarman, Daniel L. Matera, Kristen Loesel, Christopher D. Davidson, Harrison L. Hiraki, Xiaotian Tan, Eve H. Shikanov, Robert N. Kent, Carole Parent, Xudong Fan, Ariella Shikanov, Matthew L. Kutys, Brendon M. Baker   +17 more
wiley   +1 more source

Serum Levels of Tumor Necrosis Factor-α and Vascular Endothelial Growth Factor in the Subtypes of Clinical High Risk Individuals: A Prospective Cohort Study [Letter]

Neuropsychiatric Disease and Treatment, 2023
Lisa Andriani Lienggonegoro,* Frans Dany,* Novaria Sari Dewi Panjaitan* Center for Biomedical Research, Research Organization for Health, National Research and Innovation Agency (BRIN), Cibinong Science Center, Cibinong, West Java, Indonesia ...
Lienggonegoro LA, Dany F, Panjaitan NSD
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LMO7 Suppresses Tumor‐Associated Macrophage Phagocytosis of Tumor Cells Through Degradation of LRP1

Advanced Science, EarlyView.
LMO7 in tumor‐associated macrophages suppresses phagocytosis of tumor cells and limits cytotoxic T lymphocytes infiltration, fostering tumor progression. Mechanistically, LMO7 mediates the ubiquitination and degradation of the phagocytic receptor LRP1, impairing its ability to engulf tumor cells and driving macrophages toward an antitumor phenotype ...
Mengkai Li, Tao Wang, Yuwen Zhong, Zhiming Wang, Wei Li, Zejian Wang, Xinyi Yang, Yu Qiao, Jianfeng Xiang, Wei Gu, Zishu Wang, Lei Sun, Feng Qian   +12 more
wiley   +1 more source

Angiogenic gene expression and vascular density are reflected in ultrasonographic features of synovitis in early Rheumatoid Arthritis: an observational study. [PDF]

, 2015
INTRODUCTION: Neovascularization contributes to the development of sustained synovial inflammation in the early stages of Rheumatoid Arthritis. Ultrasound (US) provides an indirect method of assessing synovial blood flow and has been shown to correlate ...
Kelly, S, Maria DiCicco, Hands, RE, Frances Humby, Riahi, S, Nora Ng, Michele Bombardieri, Arti Mahto, Sudeh Riahi, Humby, F, DiCicco, M, Rebecca E Hands, Marrelli, A, Pitzalis, C, Stephen Kelly, Pyne, D, Lu Zou, Bombardieri, M, Mahto, A, Ng, N, Costantino Pitzalis, Zou, L, Debasish Pyne, Alessandra Marrelli   +23 more
core   +1 more source

Engineering Osteoimmune Responses with Functionalized Orthopedic Implants for Post‐Operative Osteosarcoma Treatment

Advanced Science, EarlyView.
Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong, Lingshuang Wang, Hui Zhang, Menghuan Li, Zhong Luo, Yan Hu, Chunyuan Cai   +6 more
wiley   +1 more source

VEGF-C and VEGF-D blockade inhibits inflammatory skin carcinogenesis.

, 2013
VEGF-C and VEGF-D were identified as lymphangiogenic growth factors and later shown to promote tumor metastasis, but their effects on carcinogenesis are poorly understood. Here, we have studied the effects of VEGF-C and VEGF-D on tumor development in the
Karaman, Sinem, Proulx, Steven T, Bry, Maija, Aebischer, David, Alitalo, Annamari K, Schneider, Nicole, Jost, Manuela, Detmar, Michael, Martino, Stefania   +8 more
core   +1 more source

Structural and functional characterization of the intracellular kinase domain of vascular endothelial growth factor receptor-2 [PDF]

, 2013
Vascular Endothelial Growth Factors (VEGFs) are key players in blood and lymphatic vessel development and homeostasis. The family consists of five members, VEGF-A, -B, -C, -D and placenta growth factor (PLGF).
Manni, Sandro
core   +1 more source

Survivin and VEGF as novel biomarkers in diagnosis of endometriosis [PDF]

Journal of Medical Biochemistry, 2016
Background: The aim of this study was to investigate the role of peripheral blood markers as additional diagnostic tools to transvaginal ultrasound (TVU) findings in the diagnosis of endometriosis.
Aćimović Milena, Vidaković Snežana, Milić Nataša, Jeremić Katarina, Marković Miloš, Milošević-Đerić Ana, Lazović-Radonjić Gordana   +6 more
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