Results 11 to 20 of about 384,919 (304)

Benzodiazepine receptor agonist carbacetam modulates the level of vascular endothelial growth factor in the retina of rats with streptozotocin-induced diabetes [PDF]

The Ukrainian Biochemical Journal, 2023
One of the primary mechanisms of retinal neurodegeneration in diabetes mellitus is gamma-aminobutyric acid (GABA) deficiency that makes the use of GABA-benzodiazepine receptor modulators a promising option for the correction of this diabetic complication.
S. V. Ziablitsev , D. B. Zhupan, A. O. Tykhomyrov, O. O. Dyadyk   +3 more
doaj   +1 more source

VEGF family members : modulators of tumor angiogenesis and lymphangiogenesis [PDF]

, 2006
Members of the vascular endothelial growth factor (VEGF) family and their receptors (VEGFR) play an essential role in the development and maintenance of the blood and lymphatic vasculature.
Kopfstein, Lucie
core   +1 more source

Mechanisms of vascular morphogenesis and stabilization by VEGF dose [PDF]

, 2014
VEGF is the master regulator of angiogenesis and the most investigated factor in therapeutic angiogenesis approaches to induce the growth of new vessels that could restore oxygen and nutrients supply in tissues affected by ischemia.
Groppa, Elena
core   +1 more source

Expression of Diverse Angiogenesis Factor in Different Stages of the 4T1 Tumor as a Mouse Model of Triple-Negative Breast Cancer [PDF]

Advanced Pharmaceutical Bulletin, 2020
Purpose: Triple-negative breast cancer (TNBC) is specified by high vascularity and repetitious metastasis. Although several studies have indicated that angiogenesis has an important role in invasive breast cancer, a suitable model of TNBC that can show ...
Saba Malekian, Marveh Rahmati, Soyar Sari, Monireh Kazemimanesh, Raheleh Kheirbakhsh, Ahad Muhammadnejad, Saeid Amanpour   +6 more
doaj   +1 more source

VEGF-A, VEGF-C, and VEGF-D in Colorectal Cancer Progression

Neoplasia, 2001
We aimed to assess the relationship of the angiogenic cytokines VEGF-A, VEGF-C, and VEGF-D and their receptors VEGFR-2 and VEGFR-3 in the adenoma-carcinoma sequence and in metastatic spread of colorectal cancer (CRC). mRNA expression levels were measured using semi-quantitative reverse transcription polymerase chain reaction in 70 CRC (35 with paired ...
Mark L. George, Matthew G. Tutton, Frank Janssen, Abed Arnaout, A. Muti Abulafi, Suzanne A. Eccles, R. Ian Swift   +6 more
openaire   +3 more sources

VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia [PDF]

, 2003
Vascular endothelial growth factor (VEGF-A) is a major regulator of blood vessel formation and function. it controls several processes in endothelial cells, such as proliferation, survival, and migration, but it is not known how these are coordinately ...
Shima, D., Christiana Ruhrberg, Betsholtz, C, Jeltsch, M, Abramsson, A., Shima, D, Matthew Golding, Lundkvist, A, Lundkvist, A., Golding, M, David Shima, Ruhrberg, C, Christopher Mitchell, Mitchell, C, Betsholtz, C., Kari Alitalo, Gerhardt, H, Ruhrberg, C., Christer Betsholtz, Golding, M., Jeltsch, M., Holger Gerhardt, Abramsson, A, Alitalo, K, Andrea Lundkvist, Fruttiger, M., Gerhardt, H., Alitalo, K., Alexandra Abramsson, Mitchell, C., Fruttiger, M, Michael Jeltsch, Marcus Fruttiger   +32 more
core   +1 more source

Immunoreactivity of the anti-VEGF-A121 and anti-VEGF-A165 monoclonal antibodies.

, 2023
Mixture of rhVEGF-A121, rhVEGF-A165 and rhVEGF-A189 (50 μg each) were subjected to 15% SDS Polyacrylamide Gel Electrophoresis (SDS-PAGE). The transferred membrane was detected with anti-VEGF-A polyclonal antibody (left panel), anti-VEGF-A165 monoclonal ...
Yoko Oyama (600027), Aryal Bibek (15198524), Taiji Sakamoto (104961), Kazunori Takenouchi (15198521), Kazuhiko Higurashi (15198527), Shingo Yamada (339487), Hideaki Kanda (15198539), Akito Tabaru (15198530), Sadayuki Higashi (15198533), Hiroto Terasaki (104937), Chieko Fujisaki (15198536), Keiichi Inoue (466261), Masashi Okawa (8951294), Kiyonori Tanoue (14928179), Yoshiharu Soga (13883911), Munekazu Yamakuchi (220194), Teruto Hashiguchi (464609)   +16 more
core   +1 more source

VEGF₁₂₁b and VEGF₁₆₅b are weakly angiogenic isoforms of VEGF-A.

Molecular cancer, 2010
Different isoforms of VEGF-A (mainly VEGF₁₂₁, VEGF₁₆₅ and VEGF189) have been shown to display particular angiogenic properties in the generation of a functional tumor vasculature. Recently, a novel class of VEGF-A isoforms, designated as VEGF(xxx)b, generated through alternative splicing, have been described.
Pio, R. (Rubén), Agorreta, J. (Jackeline), Hermida, J. (José), Larrayoz, M. (Marta), Montuenga-Badia, L.M. (Luis M.), Catena, R. (R.), Molina, E. (Eva), Larzabal, L. (Leyre), Montes, R. (Ramón), Calvo-González, A. (Alfonso)   +9 more
openaire   +3 more sources

VEGF(164)-mediated inflammation is required for pathological, but not physiological, ischemia-induced retinal neovascularization [PDF]

, 2003
Hypoxia-induced VEGF governs both physiological retinal vascular development and pathological retinal neovascularization. In the current paper, the mechanisms of physiological and pathological neovascularization are compared and contrasted.
Ogura, Y, Ng, Yin-Shan, Adamis, Anthony P., Kenji Yamashiro, Usui, Tomohiko, Hida, Tetsuo, Yuichi Kaji, Evangelos S. Gragoudas, Yin-Shan Ng, Shiro Amano, Amano, Shiro, Miller, Joan W., Yuichiro Ogura, Patricia A. D'Amore, Ambati, Jayakrishna, Shima, David T., Gragoudas, Evangelos S., Miller, JW, D'Amore, PA, Yoshihisa Oguchi, Hida, T, Ishida, S, Gragoudas, ES, Usui, T, Tetsuo Hida, Ogura, Yuichiro, Tomohiko Usui, Jayakrishna Ambati, Shima, DT, Joan W. Miller, Kaji, Yuichi, D\u27Amore, Patricia A., Ambati, J, Adamis, AP, Anthony P. Adamis, Kaji, Y, Yamashiro, K, Amano, S, Oguchi, Y, Oguchi, Yoshihisa, David T. Shima, Yamashiro, Kenji, Susumu Ishida, Ishida, Susumu, Ng, YS   +44 more
core   +1 more source

Canstatin represses glioma growth by inhibiting formation of VM-like structures

Translational Neuroscience, 2021
Vasculogenic mimicry (VM) is different from classical tumor angiogenesis and does not depend on endothelial cells. VM is closely related to the prognosis of various cancers. Canstatin was first identified as an endogenous angiogenesis inhibitor.
Ma Yuqiang, Wu Tao, Zhou Houjie, He Guilu, Li Yifei, Wang Bocheng, Guo Qiang, Chen Baodong, Li Weiping   +8 more
doaj   +1 more source