Results 61 to 70 of about 539,443 (278)

MiRNA-145 increases therapeutic sensibility to gemcitabine treatment of pancreatic adenocarcinoma cells. [PDF]

, 2016
Pancreatic adenocarcinoma is one of the most leading causes of cancer-related deaths worldwide. Although recent advances provide various treatment options, pancreatic adenocarcinoma has poor prognosis due to its late diagnosis and ineffective therapeutic
Chen, Qiu-Dan, Ge, Xin, Jiang, Bing-Hua, Lin, Yong, Liu, Ling-Zhi, Lu, Yuan, Shi, Zhu-Mei, Wang, Min, Wen, Yiyang   +8 more
core   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Genipin Inhibits Hypoxia-Induced Accumulation of HIF-1α and VEGF Expressions in Human Cervical Carcinoma Cells [PDF]

Kosin Medical Journal, 2019
Objectives Hypoxia—a characteristic of almost all types of solid tumors—has been associated with poor outcomes in several human malignancies. Genipin—an active constituent of Gardenia fruit— has been reported to exert an anti-tumor effect in several ...
Cho Eui Jin, Jung Hyun Lee, Geun Joo Kim, Tae Hwa Lee   +3 more
doaj   +1 more source

Circulating miRNA 20a, miRNA 140-5p and VEGF as Predictive Biomarkers of Metastasis in Liquid Biopsy of Breast Cancer Patients

Archives of Pharmaceutical Sciences Ain Shams University, 2021
Background: MicroRNAs (miRNAs) are critical modulators in breast carcinogenesis. Metastasis remains the underlying cause of breast cancer related mortality.
Sherihan G AbdelHamid, Hany AbdelAziz, Amany Kamal   +2 more
doaj   +1 more source

Correlation from undiluted vitreous cytokines of untreated central retinal vein occlusion with spectral domain optical coherence tomography [PDF]

, 2013
Purpose: To correlate inflammatory and proangiogenic key cytokines from undiluted vitreous of treatment-naïve central retinal vein occlusion (CRVO) patients with SD-OCT parameters. Methods: Thirty-five patients (age 71.1 years, 24 phakic, 30 nonischemic)
Cinatl, Jindrich, Koch, Frank H., Kohnen, Thomas, Koss, Michael Janusz, Pfister, Marcel, Rejdak, Robert, Ribeiro, Ramiro M., Rothweiler, Florian, Schubert, Ralf   +8 more
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Effects of Carvacrol in an Experimentally Induced Esophageal Burn Model: Expression of VEGF and Caspase-3 Proteins

Journal of Investigative Surgery, 2021
Introduction We investigated the therapeutic effects of carvacrol in an experimental esophageal burn rat model with immunohistochemical techniques. Materials and Methods: Three groups were included in this study, composed of eight Wistar albino rats each.
Hikmet Zeytun, Ebru Gökalp Özkorkmaz
doaj   +1 more source

???????????????????? ???????????????????? ?? ?????????????????????? ?????????????????????????????? ?????????????? ?????????? (VEGF) ?? ?????????????? ?????????????????? ?? ?????????????????????? ?????? [PDF]

, 2019
This paper presents the results of the study of serum levels of melatonin and VEGF with various severity of psoriasis and with sleep disorder and without it. The study revealed significant increase of VEGF levels and decrease of serum levels of melatonin with maximum deviation in severe disease.
openaire   +3 more sources

VEGF: inflammatory paradoxes [PDF]

Pathogens and Global Health, 2015
Invited commentary on ‘VEGF and LPS synergistically silence inflammatory response to Plasmodium berghei infection and protect against cerebral malaria’ and ‘Vascular Endothelial Growth factor (VEGF) and Lovastatin suppress the inflammatory response to Plasmodium berghei infection and protect against Experimental Cerebral Malaria’ by Canavese et al.
Georges E R, Grau, Mike B, Thompson, Christopher R, Murphy   +2 more
openaire   +2 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source