Archives of Pharmaceutical Sciences Ain Shams University, 2021 Background: MicroRNAs (miRNAs) are critical modulators in breast carcinogenesis. Metastasis remains the underlying cause of breast cancer related mortality.
Sherihan G AbdelHamid +2 more
doaj +1 more source
KRAS mutation-driven angiopoietin 2 bestows anti-VEGF resistance in epithelial carcinomas [PDF]
, 2023 Kayoko Hosaka +13 more
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Involvement of pro-inflammatory cytokines and growth factors in the pathogenesis of Dupuytren's contracture: a novel target for a possible future therapeutic strategy? [PDF]
, 2015 Dupuytren's contracture (DC) is a benign fibro-proliferative disease of the hand causing fibrotic nodules and fascial cords which determine debilitating contracture and deformities of fingers and hands.
Alberto Signore +11 more
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Journal of Investigative Surgery, 2021 Introduction We investigated the therapeutic effects of carvacrol in an experimental esophageal burn rat model with immunohistochemical techniques. Materials and Methods: Three groups were included in this study, composed of eight Wistar albino rats each.
Hikmet Zeytun, Ebru Gökalp Özkorkmaz
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Modifications at the C-Terminus To Improve Pyrrole−Imidazole Polyamide Activity in Cell Culture [PDF]
, 2009 Pyrrole−imidazole (Py-Im) hairpin polyamides are a class of small molecule DNA minor groove binding compounds that have been shown to modulate endogenous gene expression in cell culture.
Dervan, Peter B., Jacobs, Claire S.
core +2 more sources
???????????????????? ???????????????????? ?? ?????????????????????? ?????????????????????????????? ?????????????? ?????????? (VEGF) ?? ?????????????? ?????????????????? ?? ?????????????????????? ?????? [PDF]
, 2019 This paper presents the results of the study of serum levels of melatonin and VEGF with various severity of psoriasis and with sleep disorder and without it. The study revealed significant increase of VEGF levels and decrease of serum levels of melatonin with maximum deviation in severe disease.
openaire +3 more sources
VEGF: inflammatory paradoxes [PDF]
Pathogens and Global Health, 2015 Invited commentary on ‘VEGF and LPS synergistically silence inflammatory response to Plasmodium berghei infection and protect against cerebral malaria’ and ‘Vascular Endothelial Growth factor (VEGF) and Lovastatin suppress the inflammatory response to Plasmodium berghei infection and protect against Experimental Cerebral Malaria’ by Canavese et al.
Georges E R, Grau +2 more
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Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma
Molecular Oncology, EarlyView.PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source