Results 331 to 340 of about 2,633,569 (375)

VEGFs, receptors and angiogenesis

Seminars in Cancer Biology, 1999
Angiogenesis, the formation of new blood vessels from pre--existing ones, is central for both normal development and homeostasis as well as in certain pathological conditions. The vascular endothelial growth factors (VEGFs) and their receptors are prime regulators of both physiological and pathological angiogenesis. The different VEGFs have overlapping
T, Veikkola, K, Alitalo
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Abstract LB-346: Dual inhibition of Ang-2 and VEGF receptors normalizes tumor vasculature and prolongs survival in glioblastoma by altering macrophages

Tumor Biology, 2016
OBJECTIVE: Here we aimed to overcome resistance to anti-VEGF therapy in glioblastoma (GBM), the most common and aggressive adult primary brain tumor.
T. Peterson, N. Kirkpatrick, Yuhui Huang, C. Farrar, K. Marijt, Jonas Kloepper, Meenal Datta, Zohreh Amoozgar, G. Seano, K. Jung, W. Kamoun, Trupti D Vardam, M. Snuderl, J. Goveia, Sampurna Chatterjee, Ana L. Batista, A. Muzikansky, C. Leow, Lei Xu, T. Batchelor, D. Duda, D. Fukumura, R. Jain   +22 more
semanticscholar   +1 more source

VEGF and VEGF receptors are differentially expressed in chondrocytes

Bone, 2007
During long bone development, cartilage replacement by bone is governed in part by angiogenesis. Although it has been demonstrated that vascular endothelial growth factor (VEGF-A) is crucial during endochondral ossification, little is known about the involvement of the other VEGF family members.
Bluteau, G., Julien, M., Magne, D., Mallein-Gerin, F., Weiss, P., Daculsi, G., Guicheux, J.   +6 more
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VEGF receptor trafficking in angiogenesis

Biochemical Society Transactions, 2009
The intracellular trafficking of receptors provides a way to control the overall sensitivity of a cell to receptor stimulation. These sorting pathways are also used to shape the balance of signals that are generated in response to receptor activation.
Scott, Alice, Mellor, Harry
openaire   +3 more sources

VEGF-receptor signal transduction

Trends in Biochemical Sciences, 2003
The vascular endothelial growth factor (VEGF) family of ligands and receptors has been the focus of attention in vascular biology for more than a decade. There is now a consensus that the VEGFs are crucial for vascular development and neovascularization in physiological and pathological processes in both embryo and adult.
Michael J, Cross, Johan, Dixelius, Taro, Matsumoto, Lena, Claesson-Welsh   +3 more
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VEGF Receptor Signal Transduction

Science Signaling, 2001
The family of vascular endothelial growth factors (VEGFs) currently includes VEGF-A, -B, -C, -D, -E, and placenta growth factor (PlGF). Several of these factors, notably VEGF-A, exist as different isoforms, which appear to have unique biological functions.
T, Matsumoto, L, Claesson-Welsh
openaire   +2 more sources

VEGF and its receptors

International Congress Series, 2004
Abstract Vascular endothelial growth factor (VEGF) is a key regulator of physiological angiogenesis. The biological effects of VEGF are mediated by two tyrosine kinase receptors, VEGFR-1 and VEGFR-2. T here is now compelling evidence that VEGF is implicated in pathological angiogenesis such as that occurring in cancer and intraocular neovascular ...
openaire   +1 more source

Functional interaction of VEGF‐C and VEGF‐D with neuropilin receptors

The FASEB Journal, 2006
ABSTRACT Lymphatic vascular development is regulated by vascular endothelial growth factor receptor‐3 (VEGFR‐3), which is activated by its ligands VEGF‐C and VEGF‐D. Neuropilin‐2 (NP2), known to be involved in neuronal development, has also been implicated to play a role in lymphangiogenesis. We aimed to elucidate
KÄRPÄNEN T, HECKMAN CA, KESKITALO S, JELTSCH M, OLLILA H, NEUFELD G, TAMAGNONE, Luca, ALITALO K.   +7 more
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Molecular Biology of the VEGF and the VEGF Receptor Family

Seminars in Thrombosis and Hemostasis, 2000
Vascular endothelial growth factor (VEGF) is the founding member of a still growing family of endothelial cell growth factors. The diverse functions of VEGF and its homologues (PIGF, VEGF-B, VEGF-C, VEGF-D, and VEGF-E) can be explained by their differential binding to the three signaling VEGF receptors.
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Disease-specific expression of VEGF and its receptors in AML cells: possible autocrine pathway of VEGF/type1 receptor of VEGF in t(15;17) AML and VEGF/type2 receptor of VEGF in t(8;21) AML

Leukemia & Lymphoma, 2006
Various angiogenic factors, such as vascular endothelial growth factor (VEGF) and an associated molecule, placenta growth factor (PlGF), are thought to be important for normal and malignant hematopoiesis. This study examined mRNA expression of VEGF, PlGF and receptors for these molecules in AML cells and identified the disease-specific patterns of ...
A, Hiramatsu, H, Miwa, M, Shikami, T, Ikai, E, Tajima, H, Yamamoto, N, Imai, A, Hattori, T, Kyo, M, Watarai, K, Miura, A, Satoh, M, Itoh, A, Imamura, H, Mihara, Y, Katoh, M, Nitta   +16 more
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