Results 331 to 340 of about 2,650,230 (376)

VEGFs, receptors and angiogenesis

Seminars in Cancer Biology, 1999
Angiogenesis, the formation of new blood vessels from pre--existing ones, is central for both normal development and homeostasis as well as in certain pathological conditions. The vascular endothelial growth factors (VEGFs) and their receptors are prime regulators of both physiological and pathological angiogenesis. The different VEGFs have overlapping
T, Veikkola, K, Alitalo
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VEGF-receptor signal transduction

Trends in Biochemical Sciences, 2003
The vascular endothelial growth factor (VEGF) family of ligands and receptors has been the focus of attention in vascular biology for more than a decade. There is now a consensus that the VEGFs are crucial for vascular development and neovascularization in physiological and pathological processes in both embryo and adult.
Michael J, Cross, Johan, Dixelius, Taro, Matsumoto, Lena, Claesson-Welsh   +3 more
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VEGF Receptor Signal Transduction

Science Signaling, 2001
The family of vascular endothelial growth factors (VEGFs) currently includes VEGF-A, -B, -C, -D, -E, and placenta growth factor (PlGF). Several of these factors, notably VEGF-A, exist as different isoforms, which appear to have unique biological functions.
T, Matsumoto, L, Claesson-Welsh
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VEGF receptor trafficking in angiogenesis

Biochemical Society Transactions, 2009
The intracellular trafficking of receptors provides a way to control the overall sensitivity of a cell to receptor stimulation. These sorting pathways are also used to shape the balance of signals that are generated in response to receptor activation.
Scott, Alice, Mellor, Harry
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VEGF and VEGF receptors are differentially expressed in chondrocytes

Bone, 2007
During long bone development, cartilage replacement by bone is governed in part by angiogenesis. Although it has been demonstrated that vascular endothelial growth factor (VEGF-A) is crucial during endochondral ossification, little is known about the involvement of the other VEGF family members.
Bluteau, G., Julien, M., Magne, D., Mallein-Gerin, F., Weiss, P., Daculsi, G., Guicheux, J.   +6 more
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Human EP3I prostanoid receptor induces VEGF and VEGF receptor-1 mRNA expression

Biochemical and Biophysical Research Communications, 2008
A critical event in tumor development is the formation of new blood vessels to provide oxygen, nutrients and growth factors to the rapidly growing cancer cells. This process of angiogenesis is complex, however, it is well established that vascular endothelial growth factor (VEGF)-mediated signaling is an important early event.
Tomoko, Taniguchi, Hiromichi, Fujino, Davelene D, Israel, John W, Regan, Toshihiko, Murayama   +4 more
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VEGF and its receptors

International Congress Series, 2004
Abstract Vascular endothelial growth factor (VEGF) is a key regulator of physiological angiogenesis. The biological effects of VEGF are mediated by two tyrosine kinase receptors, VEGFR-1 and VEGFR-2. T here is now compelling evidence that VEGF is implicated in pathological angiogenesis such as that occurring in cancer and intraocular neovascular ...
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Gremlin: vexing VEGF receptor agonist

Blood, 2010
Abstract Gremlins are mischievous creatures in English folklore, believed to be the cause of otherwise unexplainable breakdowns (the word gremlins is derived from the Old English “gremian” or “gremman,” “to vex”). Gremlin (or Gremlin-1) is also the designation of a secreted protein that is known to regulate bone formation during ...
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VEGF–VEGF receptor complexes as markers of tumor vascular endothelium

Journal of Controlled Release, 2001
Vascular endothelial growth factor (VEGF) is a primary stimulant of the vascularization of solid tumors and has therefore been the focus of intense research aimed at blocking its activity in solid tumors. VEGF production by tumor cells is induced by oncogenic gene mutations and hypoxic conditions inside the tumor mass.
R A, Brekken, P E, Thorpe
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VEGF Receptor Signaling and Endothelial Function

IUBMB Life, 2001
AbstractAngiogenesis, the formation of new blood vessels from preexisting ones, is a central process during normal development and during pathological repair. Vascular endothelial growth factor‐A (VEGF‐A) can stimulate both physiological and pathological angiogensis.
S, Kliche, J, Waltenberger
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