Results 341 to 350 of about 2,650,230 (376)

Functional interaction of VEGF‐C and VEGF‐D with neuropilin receptors

The FASEB Journal, 2006
ABSTRACT Lymphatic vascular development is regulated by vascular endothelial growth factor receptor‐3 (VEGFR‐3), which is activated by its ligands VEGF‐C and VEGF‐D. Neuropilin‐2 (NP2), known to be involved in neuronal development, has also been implicated to play a role in lymphangiogenesis. We aimed to elucidate
KÄRPÄNEN T, HECKMAN CA, KESKITALO S, JELTSCH M, OLLILA H, NEUFELD G, TAMAGNONE, Luca, ALITALO K.   +7 more
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VEGF‐A, VEGF‐D, VEGF receptor‐1, VEGF receptor‐2, NF‐KB, and RAGE in atherosclerotic lesions of diabetic Watanabe heritable hyperlipidemic rabbits

The FASEB Journal, 2006
Plaque angiogenesis may be associated with the development of unstable and vulnerable plaques. Vascular endothelial growth factors (VEGFs) are potent angiogenic factors that can affect plaque neovascularization. Our objective was to determine the effect of diabetes on atherosclerosis and on the expression of angiogenesis‐related ...
Himadri Roy, Shalini Bhardwaj, Mohan Babu, Ilze Kokina, Sanna Uotila, Tiia Ahtialansaari, Teemu Laitinen, Juhana Hakumaki, Markku Laakso, Karl‐Heinz Herzig, Seppo Ylä‐Herttuala, Himadri Roy, Shalini Bhardwaj, Mohan Babu, Ilze Kokina, Sanna Uotila, Tiia Ahtialansaari, Teemu Laitinen, Juhana Hakumaki, Markku Laakso, Karl‐Heinz Herzig, Seppo Ylä‐Herttuala   +21 more
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The VEGF Receptor Family

2015
The vascular endothelial growth factor (VEGF) family of ligands and receptors has been implicated in vascular development during embryogenesis. There is now a consensus that VEGF receptor signaling is also central to pathological angiogenesis associated with cancer, intraocular neovascular disorders, and other conditions.
Guanglei Zhuang, Napoleone Ferrara
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Molecular Biology of the VEGF and the VEGF Receptor Family

Seminars in Thrombosis and Hemostasis, 2000
Vascular endothelial growth factor (VEGF) is the founding member of a still growing family of endothelial cell growth factors. The diverse functions of VEGF and its homologues (PIGF, VEGF-B, VEGF-C, VEGF-D, and VEGF-E) can be explained by their differential binding to the three signaling VEGF receptors.
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VEGF and VEGF Receptor Expression after Experimental Brain Contusion in Rat

Journal of Neurotrauma, 2005
Angiogenesis following traumatic brain injury (TBI) may be of importance not only for post-traumatic reparative processes but also for the development of secondary injuries. Vascular endothelial growth factor (VEGF) is a major regulator of endothelial cell proliferation, angiogenesis, and vascular permeability, though its possible involvement in ...
Mattias K, Sköld, Christina, von Gertten, Ann-Christin, Sandberg-Nordqvist, Tiit, Mathiesen, Staffan, Holmin   +4 more
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Structure of a VEGF–VEGF receptor complex determined by electron microscopy

Nature Structural & Molecular Biology, 2007
Receptor tyrosine kinases are activated upon ligand-induced dimerization. Here we show that the monomeric extracellular domain of vascular endothelial growth factor (VEGF) receptor-2 (VEGFR-2) has a flexible structure. Binding of VEGF to membrane-distal immunoglobulin-like domains causes receptor dimerization and promotes further interaction between ...
Claudia, Ruch, Georgios, Skiniotis, Michel O, Steinmetz, Thomas, Walz, Kurt, Ballmer-Hofer   +4 more
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VEGF receptor signal transduction.

Methods in enzymology, 2009
Signal transduction by vascular endothelial growth factors (VEGFs) through their cognate VEGF receptor tyrosine kinases follows the consensus scheme for receptor tyrosine kinases. Thus, binding of ligand induces receptor dimerization and activation of the tyrosine kinase through transphosphorylation between receptor molecules, leading to initiation of ...
Xiujuan, Li, Lena, Claesson-Welsh, Masabumi, Shibuya   +2 more
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Disease-specific expression of VEGF and its receptors in AML cells: possible autocrine pathway of VEGF/type1 receptor of VEGF in t(15;17) AML and VEGF/type2 receptor of VEGF in t(8;21) AML

Leukemia & Lymphoma, 2006
Various angiogenic factors, such as vascular endothelial growth factor (VEGF) and an associated molecule, placenta growth factor (PlGF), are thought to be important for normal and malignant hematopoiesis. This study examined mRNA expression of VEGF, PlGF and receptors for these molecules in AML cells and identified the disease-specific patterns of ...
A, Hiramatsu, H, Miwa, M, Shikami, T, Ikai, E, Tajima, H, Yamamoto, N, Imai, A, Hattori, T, Kyo, M, Watarai, K, Miura, A, Satoh, M, Itoh, A, Imamura, H, Mihara, Y, Katoh, M, Nitta   +16 more
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Regulation of Angiogenesis by Controlling VEGF Receptor

Annals of the New York Academy of Sciences, 2000
Abstract: The endothelial cells cultured in collagen gel caused upregulation of KDR expression, which resulted in an increase in tube formation. Endothelial cells exposed to high glucose (33 mmol/l) for 30 days increased the tube formation induced by VEGF, but not by serum and bFGF.
S I, Murota, M, Onodera, I, Morita
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Functions of the VEGF/VEGF Receptor System in the Vascular System

Seminars in Thrombosis and Hemostasis, 2000
The vascular endothelial growth factor (VEGF)/VEGF receptor system plays a central regulatory role in physiological and pathological angiogenesis. During embryogenesis, the VEGF/VEGF receptor system is critically involved in the formation of the vascular system by regulating both the growth and the survival of blood vessels.
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