Results 341 to 350 of about 2,633,569 (375)

VEGF–VEGF receptor complexes as markers of tumor vascular endothelium

Journal of Controlled Release, 2001
Vascular endothelial growth factor (VEGF) is a primary stimulant of the vascularization of solid tumors and has therefore been the focus of intense research aimed at blocking its activity in solid tumors. VEGF production by tumor cells is induced by oncogenic gene mutations and hypoxic conditions inside the tumor mass.
R A, Brekken, P E, Thorpe
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Structure of a VEGF–VEGF receptor complex determined by electron microscopy

Nature Structural & Molecular Biology, 2007
Receptor tyrosine kinases are activated upon ligand-induced dimerization. Here we show that the monomeric extracellular domain of vascular endothelial growth factor (VEGF) receptor-2 (VEGFR-2) has a flexible structure. Binding of VEGF to membrane-distal immunoglobulin-like domains causes receptor dimerization and promotes further interaction between ...
Claudia, Ruch, Georgios, Skiniotis, Michel O, Steinmetz, Thomas, Walz, Kurt, Ballmer-Hofer   +4 more
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Regulation of Angiogenesis by Controlling VEGF Receptor

Annals of the New York Academy of Sciences, 2000
Abstract: The endothelial cells cultured in collagen gel caused upregulation of KDR expression, which resulted in an increase in tube formation. Endothelial cells exposed to high glucose (33 mmol/l) for 30 days increased the tube formation induced by VEGF, but not by serum and bFGF.
S I, Murota, M, Onodera, I, Morita
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VEGF Receptor Signaling and Endothelial Function

IUBMB Life, 2001
AbstractAngiogenesis, the formation of new blood vessels from preexisting ones, is a central process during normal development and during pathological repair. Vascular endothelial growth factor‐A (VEGF‐A) can stimulate both physiological and pathological angiogensis.
S, Kliche, J, Waltenberger
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Functions of the VEGF/VEGF Receptor System in the Vascular System

Seminars in Thrombosis and Hemostasis, 2000
The vascular endothelial growth factor (VEGF)/VEGF receptor system plays a central regulatory role in physiological and pathological angiogenesis. During embryogenesis, the VEGF/VEGF receptor system is critically involved in the formation of the vascular system by regulating both the growth and the survival of blood vessels.
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Human EP3I prostanoid receptor induces VEGF and VEGF receptor-1 mRNA expression

Biochemical and Biophysical Research Communications, 2008
A critical event in tumor development is the formation of new blood vessels to provide oxygen, nutrients and growth factors to the rapidly growing cancer cells. This process of angiogenesis is complex, however, it is well established that vascular endothelial growth factor (VEGF)-mediated signaling is an important early event.
Tomoko, Taniguchi, Hiromichi, Fujino, Davelene D, Israel, John W, Regan, Toshihiko, Murayama   +4 more
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The VEGF Receptor Family

2015
The vascular endothelial growth factor (VEGF) family of ligands and receptors has been implicated in vascular development during embryogenesis. There is now a consensus that VEGF receptor signaling is also central to pathological angiogenesis associated with cancer, intraocular neovascular disorders, and other conditions.
Guanglei Zhuang, Napoleone Ferrara
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Expression of VEGF and VEGF Receptors in Port‐Wine Stains

Otolaryngology–Head and Neck Surgery, 2008
ProblemPort‐wine stains (PWS) are vascular anomalies that may cause significant functional and psycho‐social ramifications worsening by age. Traditional management of port‐wine stains involves pulsed dye laser treatments, however only 10% of these lesions show complete response and 35% of these recur even after complete response.
Jeevan B Ramakrishnan, Chun‐Yang Fan, Neslihan Cetin, Lisa M Buckmiller, Emre A. Vural   +4 more
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VEGF‐A, VEGF‐D, VEGF receptor‐1, VEGF receptor‐2, NF‐KB, and RAGE in atherosclerotic lesions of diabetic Watanabe heritable hyperlipidemic rabbits

The FASEB Journal, 2006
Plaque angiogenesis may be associated with the development of unstable and vulnerable plaques. Vascular endothelial growth factors (VEGFs) are potent angiogenic factors that can affect plaque neovascularization. Our objective was to determine the effect of diabetes on atherosclerosis and on the expression of angiogenesis‐related ...
Himadri Roy, Shalini Bhardwaj, Mohan Babu, Ilze Kokina, Sanna Uotila, Tiia Ahtialansaari, Teemu Laitinen, Juhana Hakumaki, Markku Laakso, Karl‐Heinz Herzig, Seppo Ylä‐Herttuala, Himadri Roy, Shalini Bhardwaj, Mohan Babu, Ilze Kokina, Sanna Uotila, Tiia Ahtialansaari, Teemu Laitinen, Juhana Hakumaki, Markku Laakso, Karl‐Heinz Herzig, Seppo Ylä‐Herttuala   +21 more
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Gene expression for VEGF-A, VEGF-C, and their receptors in murine lymphocytes and macrophages

Biochemistry (Moscow), 2007
Vascular endothelial growth factors VEGF-A and VEGF-C are the main angiogenic factors that control growth of new blood and lymphatic vessels in the organism, and they also possess several immunoregulatory activities. Expression of VEGF-A and VEGF-C mRNA as well as mRNA for VEGF receptors in lymphocytes and macrophages of naive mice was investigated ...
O I, Stepanova, A V, Krylov, V I, Lioudyno, E P, Kisseleva   +3 more
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