Results 151 to 160 of about 24,477,013 (226)

PRDM1 Knockdown Promotes Ferroptosis and Sunitinib Sensitivity by Modulating the PI3K/Akt Signaling Through Inhibition of ESM1 Transcription in Renal Cell Carcinoma

The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 9, September 2026.
ABSTRACT Renal cell carcinoma (RCC) is a commonly occurring and considerable burden on public health. Although chemotherapy benefits patients with advanced RCC, sunitinib resistance leads to a poor prognosis. Ferroptosis is also involved in sunitinib resistance in RCC.
Yi‐Shuai Zhang, Xin‐Qi Pei, Ji‐Ping Sun, Chen‐Hui Ma, Xin‐Yang Wang, Xu‐Dong Li   +5 more
wiley   +1 more source

From Synthesis to Mechanism: Biological Evaluation of a p-Toluidine-Based Thiazolidinone-Quinoline VEGFR-2 Candidate Supported by CADD. [PDF]

Int J Mol Sci
Manni E, Hussein MF, Elkady S, Abdel-Rahman AA, Hawata MA, El-Sayed WA, El-Sayed AF, El-Hema HS.   +7 more
europepmc   +1 more source

The Health Benefits of Exercise: Molecular and Cellular Mechanisms

MedComm, Volume 7, Issue 9, September 2026.
Our synthesis integrates evidence on exercise‐induced regulatory mechanisms across multiple systems (musculoskeletal, cardiovascular, nervous, metabolic and immune), cross‐system, and aging. We also discusses adaptive regulation of exercise in extreme environments, along with the prospects and challenges of multiomics and AI‐driven precision exercise ...
Peifeng Ying, Huilin Wang, Xiu Lu, Wenjuan Zhang, Zhehao Lin, Kai Wang, Shangxuan Li, Lu Chen, Mingchao Jiang, Sarkawt Hamad, Yi Wang, Jianmin Wu, Shukuan Ling   +12 more
wiley   +1 more source

IL-10 secretion by CD8 T cells orchestrates early NK cell recruitment and antitumor immunity after anti-VEGFR-2/PD-1 therapy. [PDF]

J Immunother Cancer
Geindreau M, Pignol C, Coënon L, Varin A, Racoeur C, Milian L, Roger N, Chalmin F, Vernet T, Alibert L, Bellaye PS, Thibaudin M, Louis C, Wicks I, Truntzer C, Boidot R, Paul C, Lamarthée B, Vegran F, Ghiringhelli F, Bruchard M.   +20 more
europepmc   +1 more source

Tissue‐Resident Macrophage in Inflammation and Cancer

MedComm, Volume 7, Issue 9, September 2026.
Opposing macrophage functions in inflammation and cancer converge on shared mechanistic nodes, informing cross‐disease therapeutic strategies. ABSTRACT Tissue‐resident macrophages (TRMs) are long‐lived immune cells strategically distributed across organs, where their functional plasticity enables both homeostatic maintenance and pathological ...
Siyuan Huang, Jiangbo Fan, Wenyi Liu, Di Liu, Rui Wang, Yuanyang Wang, Jianhui Sun, Huacai Zhang, Qingli Cai, Zhe Xu, Fang Xu, Jianxin Jiang, Zhen Wang, Ling Zeng   +13 more
wiley   +1 more source

Design, Synthesis, Molecular Docking, and Anticancer Activity of Chalcone Derivatives as VEGFR-2 Inhibitors. [PDF]

Molecules
Yu M, Zhang X, Zhu H, Zhang X.
europepmc   +1 more source

MRI‐based radiomics model for predicting VEGFA expression and prognosis in lower‐grade glioma

Medical Physics, Volume 53, Issue 9, September 2026.
Abstract Background Gliomas are the most common primary tumors of the central nervous system. Their treatment remains highly challenging, with high rates of associated disability and mortality. Conventional prognostic indicators no longer adequately satisfy the clinical demands of precision medicine.
Kun Zhao, Xinyu Hong, Hongrong Cheng, Shoucheng Xu, Dongliang Zhao, Jianyang Lin, Yongbing Gu, Guoqiang Ren, Baomin Chen, Liping Zhan, Yuanwei Wang   +10 more
wiley   +1 more source

Exploring market-approved azoles as potential breast cancer therapeutics targeting the VEGFR-2 biotarget. [PDF]

Sci Rep
Atta AM, Nafie MS, Ali HA, Saleh HK, Roshdy MA, Mahmoud MM, Eid EA, Ahmed MA, Gerges MS, Ghoneim AM, Refaie AH, Attia EE, Algandaby MM, Darwish KM.   +13 more
europepmc   +1 more source

Roadmap for the implementation of particle minibeam therapy

Medical Physics, Volume 53, Issue 9, September 2026.
Abstract Particle minibeam therapy (PMBT) has emerged as an advanced modality within spatially fractionated radiation therapy, using the physical properties of protons, ions, and electrons to achieve superior normal tissue sparing whilst preserving spatial dose distribution at depths that are unachievable in conventional kV or MV X‐rays.
Reem Ahmad, Oxana Actis, Adam H. Aitkenhead, Richard A. Amos, Niels Bassler, Catherine Burne, Pankaj Chaudhary, Gerd Datzmann, Umberto Deut, Fabio Di Martino, Rebecca Habgood, Simon Jolly, Emmanuel Jouglar, Eva Kasanda, Nigel Lee, Dominic Leiser, Xiangkun Li, Giuliana Milluzzo, Jessica Neubauer, Kelvin Ng Wei Siang, Hugo Palmans, Yolanda Prezado, Judith Reindl, Francesco Romano, Loris Roncali, Aikaterini Rousseti, Thomas E. Schmid, Ileana Silvestre Patallo, Frank Stephan, Anna Subiel, Edward Taylor, Annalisa Walpen, Samuel Flynn   +32 more
wiley   +1 more source

Potential Application of Cocoa Extract in Preventing Skin Cancer Through Inhibition of Adenosine Receptor A2, VEGFR-2, and BCL-2: <i>in vivo</i> and Docking Molecular Studies. [PDF]

Medeni Med J
Wahab S, Djawad K.
europepmc   +1 more source