Results 171 to 180 of about 24,477,013 (226)

Discovery of Novel Piperidinyl-Based Benzoxazole Derivatives as Anticancer Agents Targeting VEGFR-2 and c-Met Kinases. [PDF]

Pharmaceuticals (Basel)
Eldehna WM, Elsayed ZM, Elnagar MR, El-Said AH, Majrashi TA, Negmeldin AT, Saleh AM, Elrayess R, Elnahriry KA, Chen ZL, Elagawany M, Tawfik HO.   +11 more
europepmc   +1 more source

Oral Nintedanib for Refractory Generalized Keloids: A Prospective Exploratory Pilot Study

Journal of Cosmetic Dermatology, Volume 25, Issue 9, September 2026.
ABSTRACT Background Generalized keloids are severe, treatment‐refractory, disfiguring dermatoses that substantially impair physical and psychosocial well‐being and have limited effective systemic treatment options. Objective To assess the short‐term safety, tolerability, and exploratory clinical outcomes of oral nintedanib in patients with refractory ...
Chenmei Liu, Lian Zhang, Dan Sun, Aiqing Lin, Renliang He, Bin Yang   +5 more
wiley   +1 more source

The influence of VEGFR-2 blockade and focused ultrasound blood-brain barrier opening on the glioma-immune landscape. [PDF]

Neurooncol Adv
Nowak KM, Hoch MR, Breza VR, Gorick CM, Song J, Debski AC, Samuels JD, DeWitt MR, Purow BW, Bullock TN, Harris TH, Price RJ.   +11 more
europepmc   +1 more source

The High‐Intensity Zone: A Dynamic Inflammatory Hub in Lumbar Disc Degeneration

Orthopaedic Surgery, Volume 18, Issue 9, Page 1804-1818, September 2026.
The HIZ, a dynamic inflammatory hub in lumbar disc degeneration, links inflammation‐degeneration‐pain; integrating advanced diagnostics and targeted therapies offers precise management for discogenic low back pain. ABSTRACT The lumbar intervertebral disc high‐intensity zone (HIZ), a focal hyperintensity within the annulus fibrosus on T2‐weighted ...
Qi Zhou, Jingyi Cai, Weijian Zhu, Sirui Zhou, Liling Zhou, Yiyao Pei, Gang Wu   +6 more
wiley   +1 more source

Pyrazole/pyrimidine derivatives endowed with azobenzenes as dual EGFR^T790M and VEGFR-2 inhibitors: anticancer, docking, synthesis, design and ADMET assessments. [PDF]

RSC Adv
Anwer KE, Abdelgawad MA, Abdulhaleem M FA, Abd El-Sattar NEA, El-Morsy A, Nasr T, Elmowafy M, El-Adl K, Ahmed NM.   +8 more
europepmc   +1 more source

Comparative Response of Canine and Human Osteosarcoma Tumour Cell Lines to Molecularly Targeted Anticancer Agents at Clinically Relevant Exposures With Analysis of Genomic Biomarkers

Veterinary and Comparative Oncology, Volume 24, Issue 3, Page 532-544, September 2026.
ABSTRACT Osteosarcoma (OSA) is a primary bone tumour occurring in children but is also prevalent in large breed dogs. Canine OSA (cOSA) has long been viewed as analogous to human OSA (hOSA) with cOSA serving as a surrogate for development of therapeutic approaches to treat the rarer human form.
Daniel L. Gustafson, Kala A. Early, Maritza A. Morales, Klaudia A. Poplawski, Sunetra Das, Dawn L. Duval   +5 more
wiley   +1 more source

Structure-Guided Design of Benzothiazole and Benzimidazole-Based Urea Derivatives Curtailing Oncogenic Signaling via Concurrent Inhibition of VEGFR-2, EGFR, and c‑Met. [PDF]

ACS Omega
Shaheen S, Siddique A, Iftikhar A, Faisal A, Rehman HM, Murtaza G, Tahir A, Saeed A, Hassan A, Rashid U.   +9 more
europepmc   +1 more source

Identification of Novel Therapeutic Agent Candidates Through High Throughput Screening With Chemical Library Based on Molecular Subclassification in Canine Histiocytic Sarcoma Cell Lines

Veterinary and Comparative Oncology, Volume 24, Issue 3, Page 554-567, September 2026.
ABSTRACT Effective chemotherapy for canine histiocytic sarcoma (CHS) has yet to be established. In our previous study, CHS cell lines were subclassified into two groups based on their gene expression profiles: Group A and Group B. This study aimed to identify novel therapeutic agents that are effective against each CHS subgroup, and we performed high ...
Hiroki Sakuma, Hirotaka Tomiyasu, Mari Takamiya, Yuko Goto‐Koshino, Atsushi Tsukamoto, Makoto Bonkobara, Masaru Okuda   +6 more
wiley   +1 more source

Discovery of new thiadiazole-based VEGFR-2 inhibitors: design, synthesis, cytotoxicity, and apoptosis induction. [PDF]

Future Med Chem
Elkaeed EB, Elgammal WE, Elkady H, Mahdy HA, Alsfouk AA, Husein DZ, Soliman OA, Omara M, Eissa IH, Metwaly AM.   +9 more
europepmc   +1 more source

Exacerbated expansive vascular remodeling due to disturbed flow in male mice overexpressing protein disulfide isomerase‐A1

Physiological Reports, Volume 14, Issue 17, September 2026.
Abstract Vascular expansive remodeling is involved in atherosclerosis/restenosis; however, its mechanisms need further investigation. Protein‐disulfide isomerase (PDIA1), a redox chaperone from the endoplasmic reticulum and cell surface, supports vascular smooth muscle mechanoadaptation.
Júlia Martins Felipe de Souza, Tiphany Coralie De Bessa, Amanda de Almeida Silva, Carolina Gonçalves Fernandes, Leonardo Yuji Tanaka, Francisco Rafael Martins Laurindo   +5 more
wiley   +1 more source