Results 131 to 140 of about 24,477,013 (226)

Comprehensive Profiling of ac4C RNA Modification Identifies CERCAM in Cancer‐Associated Fibroblasts as a Key Prognostic and Microenvironmental Regulator in Colorectal Cancer

Cancer Reports, Volume 9, Issue 9, September 2026.
ABSTRACT Background N4‐acetylcytidine (ac4C) RNA modification has emerged as a critical epigenetic regulator in tumorigenesis and progression. However, the comprehensive landscape of ac4C modification in colorectal cancer (CRC), particularly its orchestration of the tumor microenvironment (TME) and stromal crosstalk, remains largely unexplored.
Yang Xia, Jialin Dai, Xinyi Zhou, Ruige Zhang   +3 more
wiley   +1 more source

New Chromene Derivatives as Promising VEGFR-2 Inhibitors: Experimental Cytotoxicity and Comprehensive Computational Characterization. [PDF]

Arch Pharm (Weinheim)
Elkady H, Alsfouk AA, Elkaeed EB, Elgammal WE, Mahdy HA, Nofal A, Eissa IH, Husein DZ, Amin FG, Metwaly AM.   +9 more
europepmc   +1 more source

Knockdown of RPL28 Inhibits the Progression of Clear Cell Renal Cell Carcinoma

Cancer Reports, Volume 9, Issue 9, September 2026.
ABSTRACT Background Clear cell renal cell carcinoma (ccRCC) is the most common and aggressive histological subtype of kidney cancer. Previous studies have implicated ribosomal protein L28 (RPL28) in the progression of various cancers; however, its role in ccRCC remains unclear.
Runbiao Luo, Guozhong Wu, Zhouzhou Xie, Yuchen Xiao, Wenbiao Zhu, Huiming Jiang   +5 more
wiley   +1 more source

Coumarin-based dual kinase inhibitors targeting CDK6 and VEGFR-2: experimental and computational validation. [PDF]

RSC Adv
Elkady H, Elgammal WE, Eissa IH, Husein DZ, Al-Ghulikah HA, Alshahrani GN, Amin FG, Metwaly AM, Elkaeed EB.   +8 more
europepmc   +1 more source

Cancer‐related pain: A bidirectional modulator of cancer progression

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
CRP and tumour progression engage in a dynamic, bidirectional circuit mediated by multiple mechanisms involving neuroimmunology and cancer ‐neuroscience. Analgesic interventions may affect tumour progression, while anticancer therapies can influence pain. Targeting pain in cancer may have promising therapeutic value in cancer progression.
Junzhe He, Yu Zhang, Qian Liu, Biao Yan, Peiwei Chai, Renbing Jia   +5 more
wiley   +1 more source

Endothelial VEGFR-2 Activation Precedes Severe Mucosal Injury in TNBS-Induced Colitis. [PDF]

Int J Mol Sci
Ceccariglia S, Sibilia D, Scattolini A, Saccone V, Parolini O, Armuzzi A, Papa A, Gasbarrini A, Pizzolante F.   +8 more
europepmc   +1 more source

Cinnamaldehyde From Cinnamon as a Food‐Derived Bioactive: Phytochemistry, Anticancer Mechanisms, Bioavailability, Nanoformulation and Safety

Food Frontiers, Volume 7, Issue 5, September 2026.
Cinnamaldehyde derived from Cinnamomum species exerts multitarget anticancer effects by promoting oxidative stress, mitochondrial dysfunction, apoptosis, cell‐cycle arrest, autophagy, and epigenetic changes, and by suppressing mitogen‐activated protein kinase (MAPK), phosphoinositide 3‐kinase/protein kinase B/mechanistic target of rapamycin (PI3K/Akt ...
Gervason Moriasi, Sally Kamau, Gulnaz Seitimova, Shynar Zhumagaliyeva, Javad Sharifi‐Rad, William N. Setzer, Daniela Calina   +6 more
wiley   +1 more source

Discovery of VEGFR-2 Inhibitors From Leonurus japonicus via Integrated Genetic Authentication, Molecular Networking, and In Silico Analysis. [PDF]

Arch Pharm (Weinheim)
Raviraj T, Yu CL, Intharuksa A, Lai SC, Tenderly VF, Loo YC, Chen PW, Wang SW, Purnomo KA, Kulandhaivel SR, Renadi S, Lirio S, Cheng YB, Yang YL, Hwang TL, Chang FR, Korinek M.   +16 more
europepmc   +1 more source

AKT, ATR, and Notch Inhibitors Radiosensitize a Preclinical Model of Adenoid Cystic Carcinoma

Head &Neck, Volume 48, Issue 9, Page 2364-2376, September 2026.
ABSTRACT Background Adenoid Cystic Carcinoma (ACC) is a rare and lethal type of head and neck cancer. Standard therapy involves surgery followed by radiation therapy. The majority of ACC has MYB overexpression and MYB‐NFIB gene fusions, while Notch mutations are associated with aggressive behavior.
Shivani Thoidingjam, Sushmitha Sriramulu, Asya Haider Muratoglu, Stephen Brown, Oudai Hassan, Benjamin Movsas, Haythem Ali, Steven Chang, Patrick Ha, Farzan Siddiqui, Shyam Nyati   +10 more
wiley   +1 more source

Dual Targeting Strategies in Cancer: Carbonic Anhydrase IX Inhibitors Targeting EGFR or VEGFR-2. [PDF]

Molecules
Charissopoulos E, Pontiki E.
europepmc   +1 more source