Results 121 to 130 of about 17,703,275 (296)
Brazilian Journal of Medical and Biological Research, 2018 Neonatal asphyxia occurs due to reduction in oxygen supply to vital organs in the newborn. Rapid restoration of oxygen to the lungs after a long period of asphyxia can cause lung injury and decline of respiratory function, which result from the activity ...
R.L. Figueira +6 more
doaj +1 more source
ISL suppressed VEGFR-2 kinase activity and its downstream signaling.
, 2013 (A) HUVECs were treated with various concentrations of ISL for 12 h under the stimulation of VEGF (20 ng/ml). Western blotting results showed that the p-VEGFR-2 expression was gradually down-regulated with the increasing dose of ISL; (B) ISL inhibited ...
Zhiyu Wang (282312) +9 more
core +1 more source
British Journal of Pharmacology, EarlyView.Abstract Vascular toxicity is a growing concern in cancer patients receiving vascular endothelial growth factor inhibitor (VEGFi) therapy, posing a significant threat to patient prognosis. While the primary mechanism of VEGFi‐induced vascular toxicity is linked to redox‐sensitive reactions that disrupt vascular tone, leading to hypertension and ...
Grace Whelan, Karla B. Neves
wiley +1 more source
British Journal of Pharmacology, EarlyView.Blood vascular permeability is a hallmark of cancer and acts as an active driver of metastatic dissemination. Metastasis accounts for the vast majority of cancer deaths, yet most work has focussed on tumour‐intrinsic traits and angiogenesis, while the specific contribution of endothelial barrier regulation to intravasation and extravasation remains ...
Pierre Boucher +6 more
wiley +1 more source
Cancer Science, EarlyView.An immune dysfunction score (IDS) provides independent prognostic information in MDS and CMML, complements current risk models, mirrors disease changes, and reflects underlying immune impairment. IDS may also highlight therapeutic sensitivities, supporting its use as a practical biomarker for risk stratification and clinical follow‐up.
Yu‐Hung Wang +16 more
wiley +1 more source
The function of VEGFR-2 in GSLCs.
, 2013 (A) VEGF-induced chemotactic of GSLCs (left).
Kequiang Chen (387688) +12 more
core +1 more source
Cancer Science, EarlyView.The dose escalation part of the first‐in‐human study of E7130 in patients with advanced solid tumors determined the Recommended Phase 2 Dose of E7130 (480 μg/m2 Q3W). The dose expansion part (presented here) examined safety/preliminary efficacy in patients with squamous cell carcinoma of the head and neck and urothelial carcinoma.
Nobuaki Matsubara +15 more
wiley +1 more source
Cell Proliferation, EarlyView.A schematic diagram illustrating how 3′tiRNA‐GlyGCC promotes the endoplasmic reticulum stress (ERS) and proliferation in hypoxic pulmonary artery smooth muscle cells (PASMCs) by inhibiting the expression of myelin regulatory factor (Myrf), ultimately leading to pulmonary hypertension (PH).
Lixin Zhang +11 more
wiley +1 more source
Expression of VEGF-C and activation of its receptors VEGFR-2 and VEGFR-3 in trophoblast
, 2011 Placental villous development requires the co-ordinated action of angiogenic factors on both endothelial and trophoblast cells. Like vascular endothelial growth factor (VEGF), VEGF-C increases vascular permeability, stimulates endothelial cell ...
Dunk, C., Ahmed, As¡ S.
core
Placental VEGFR-2 and sVEGFR-2 relative mRNA levels.
, 2012 A: Schematic representation of pre-mRNA exon-intron structure of VEGFR-2 (central shadowed box not at scale) with primers used to discriminate membrane bound VEGFR-2 mRNA (upper box, exon 13-exon 16; 634 bp) and soluble VEGFR-2 mRNA (lower box, exon 13 ...
Frédéric Goffin (178225) +10 more
core +1 more source