Results 121 to 130 of about 24,477,013 (226)

Ｄｌｌ４和ＶＥＧＦＲ在氧诱导视网膜病小鼠模型中的表达及意义

Zhongshan Daxue xuebao. Yixue kexue ban, 2015
摘 要： 【目的】 为了分析Ｄｌｌ４、 ＶＥＧＦＲ－１、 ＶＥＧＦＲ－２在视网膜新生血管中的表达，探讨Ｎｏｔｃｈ１－Ｄｌｌ４信号通路在氧诱导视网膜病小鼠新生血管形成中的作用。【方法】 选用鼠龄７ ｄ的 Ｃ５７ＢＬ／６Ｊ 新生鼠３０只，分成实验组和对照组。实验组１５只，在氧浓度为（７５±２）％的密闭容器中生长５ ｄ，回到室内正常空气中；对照组１５只，在室内正常空气中生长。两组各取产后７ ｄ（７ ｄ ｐｏｓｔ－ｐａｒｔｕｍ，ｐ７）、ｐ１２、ｐ１７新生鼠 ５只，摘除眼球，取视网膜提取ＲＮＡ，以ＲＴ－ＰＣＲ ...
doaj  

VEGFR-2 and VEGFR-3 Specific Signaling in Lymphangiogenesis and Angiogenesis [PDF]

, 2007
The circulatory system consists of the blood and lymphatic vessels. While blood vessels transport oxygen, cells, and nutrients to tissues, the lymphatic vessels collect fluid, cells, and plasma proteins from tissues to return back to the blood ...
Wirzenius, Maria
core  

Generation of Self‐Organizing Macrovascular Constructs by Bioprinting Human iPSC‐Derived Mesodermal Progenitor Cells

Advanced Science, Volume 13, Issue 49, 3 September 2026.
ABSTRACT Vascularization remains a major obstacle in tissue engineering. Here, we introduce a bioprinting strategy to generate centimeter‐scale, self‐organizing “mother vessel” constructs from iPSC‐derived hiMPCs. By optimizing bioink composition, printing was accomplished in a single‐step approach. Within one week, hiMPCs differentiated into both CD31+
Leyla E. Dogan, Nathaly A. Chicaiza‐Cabezas, Florian Kleefeldt, Philipp Wörsdörfer, Jürgen Groll, Süleyman Ergün   +5 more
wiley   +1 more source

Targeting WDR12 Unleashes T‐Cell‐Mediated Antitumor Activity in Melanoma by Destabilizing CD276

Advanced Science, Volume 13, Issue 52, 18 September 2026.
WDR12 cooperates with the chaperonin subunit CCT7 to maintain CD276 stability on tumor cells, suppressing T‐cell activity and promoting immune escape. SU14813, a small‐molecule WDR12 inhibitor, reduces CD276 stability and relieves CD276‐mediated T‐cell suppression.
Jie Pan, Ruimin Chang, Meng Zhang, Qian Dong, Guanxiong Zhang, Xiang Chen, Mingliang Chen, Lixia Lu, Xiaowei Liang, Yeye Guo, Juan Su   +10 more
wiley   +1 more source

DHODH Drives Sunitinib Resistance Via a Non‐Enzymatic Mechanism by Inhibiting TRIM28 Ubiquitination and Consequent VEGFA Activation in RCC

Advanced Science, Volume 13, Issue 52, 18 September 2026.
This non‑enzymatic function of DHODH drives sunitinib resistance by competing with TRIM37 to block TRIM28 ubiquitination, thereby stabilizing TRIM28 and activating VEGFA transcription. Disrupting the DHODH–TRIM28 interaction with lisaftoclax restores drug sensitivity.
Shijie Qian, Shihang Pu, Zhipeng Xu, Yiheng Ding, Ling Jin, Baochao Li, Qi Li, Xiaohai Xi, Zengjun Wang, Jiajun Xing, Aiming Xu   +10 more
wiley   +1 more source

Assessment of the Targeted Therapeutic Potential of Naringenin‐Benzyl Piperazine Derivatives on Hypoxia‐Induced JAK/STAT Pathway in Breast and Ovarian Cancers

Archiv der Pharmazie, Volume 359, Issue 9, September 2026.
The synthesized naringenin‐benzyl piperazine derivatives 3b, 3f, and 3g exhibited potent antiproliferative and cytotoxic activities on breast tumors (MCF7 (ER‐α+), SK‐Br, MDA‐MB‐231) and ovarian cancer cells (NIH‐OVCAR‐3, and SKOV‐3). 3f was found to have the highest apoptotic effect among the other derivatives.
Hafize Özcan, Oğuzhan Doğanlar, Zeynep Banu Doğanlar, Ayşen Şuekinci Yılmaz, Ömer Zaim   +4 more
wiley   +1 more source

Recent Advances in Microwave and Ultrasound Assisted Synthesis of Quinoline Derivatives as Anticancer Agents

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
Green microwave‐ and ultrasound‐assisted synthesis enables the rapid, sustainable preparation of quinoline‐based anticancer agents with improved reaction efficiency, higher yields, and enhanced biological activity. ABSTRACT Quinoline derivatives represent a privileged class of heterocyclic compounds with remarkable structural diversity and broad ...
Rohit Pal, Gurubasavaraja Swamy Purawarga Matada, Ghanshyam Teli, Manjushree B V, Vipin K. Pandey, Shourya Pratap   +5 more
wiley   +1 more source

Mechanistic Pathways of Wound Healing: From Hemostasis to Scar‐Free Regeneration

Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.
ABSTRACT Wound healing is the critical process regulated through a harmonious coordination of cellular, molecular, pathological, and systemic communications. Normally, healing occurs in four overlapping phases, which are modified and controlled by various growth factor interactions and signaling pathways.
Devadass Jessy Mercy, Koyeli Girigoswami, Agnishwar Girigoswami   +2 more
wiley   +1 more source

Neurofibromatosis Type 1 Tumor Involving the Anterosuperior Mediastinum With a Rare c.147C>G Germline Mutation: A Case Report

Clinical Case Reports, Volume 14, Issue 9, September 2026.
ABSTRACT Neurofibromatosis type 1 (NF1) is an autosomal dominant disorder that affects multiple organ systems, most commonly the skin, peripheral nerves, and skeletal system. However, involvement of the anterior mediastinum is rare and has been sporadically reported in the literature.
Yuhao Qi, Shenghai Wang, Zhaokun Sun, Jianhua Du, Jun Li   +4 more
wiley   +1 more source

Primary Mammary Angiosarcoma in a Postmenopausal Woman: A Case Report

Cancer Reports, Volume 9, Issue 9, September 2026.
ABSTRACT Background Primary breast angiosarcoma (PAS) is a rare aggressive mesenchymal breast tumor, which predominantly affects young premenopausal women and is prone to misdiagnosis due to nonspecific clinical and imaging features. Surgical resection is the main treatment, while the efficacy of adjuvant chemoradiotherapy remains unclear.
Tingting Liu, Yueqin Xu, Qingwei Wang, Shiya Yu, Hongming Lin, Zeyi Ye, Zhiqiang Zheng, Changan Yang, Tianzi Hong   +8 more
wiley   +1 more source