Results 111 to 120 of about 17,703,275 (296)
Journal of Experimental & Clinical Cancer Research, 2017 Background Glioblastoma (GBM) is a highly migratory, invasive, and angiogenic brain tumor. Like vascular endothelial growth factor-A (VEGF-A), placental growth factor (PlGF) promotes GBM angiogenesis. VEGF-A is a ligand for both VEGF receptor-1 (VEGFR-1)
Maria Grazia Atzori +16 more
doaj +1 more source
ABL enhances VEGFR-2 internalization in ECs.
, 2016 A) Colocalization of VEGFR-2 with endosome markers EEA1 in ECs. The ECs were pretreated with ABL for 2 h following fifteen minutes of VEGF stimulation, fixed, permeablized, and labeled with anti-VEGFR-2 (red) and anti-EEA1 (green) and processed for ...
Jingshan Zhao (849409) +3 more
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Allergy, EarlyView.ABSTRACT In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal ...
F. Roth‐Walter +20 more
wiley +1 more source
Design and Synthesis VEGFR-2 Kinase Inhibitors
, 2021 The goal of this project was to synthesize VEGFR-2 Kinase inhibitors to control cancer metastasis. Twelve different VEGFR inhibitors were synthesized and analyzed with molecular docking.
Sichula, Vincent +2 more
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Andrology, EarlyView.ABSTRACT Background Cell therapy, particularly those utilizing mesenchymal stem/stromal cells (MSCs), is gaining traction as a therapeutic option for regenerative treatment in patients with limited therapeutic options. Although the safety of MSC‐based interventions is well established, uncertainties remain regarding how genetic abnormalities and ...
Marzena Zychowicz +12 more
wiley +1 more source
, 2013 (a) Keratinocytes were incubated with or without neutralizing antibodies against VEGFR-1 (A-VEGFR-1, 5 µg/ml) and VEGFR-2 (AVEGFR-2, 5 µg/ml) 24 h after treatment of 0 or 10 J/cm2 UVA, and cell apoptosis rate was examined by flow cytometry.
Zhong-Fa Lu (285979) +5 more
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New perspectives on VEGF signalling in Alzheimer's disease
Brain Pathology, EarlyView.Emery et al. bring together findings from recent multi‐omic studies, including single‐cell mRNA analysis of human post‐mortem brain tissue, and proteomic analysis of matched CSF and blood samples in large clinical studies. The authors present evidence of the involvement of altered VEGF signalling in vascular and immune dysfunction and neurodegeneration
Cherelle E. G. Emery +2 more
wiley +1 more source
Immunohistochemical study of neoangiogenesis markers in squamous cell lung cancer
Patologìâ, 2019 Aim – to study VEGFR-2 and CD34 immunohistochemical expression in squamous cell lung cancer. Materials and methods. Pathomorphological and immunohistochemical studies of surgical material from 20 patients, which were treated in ZRCOD because of SCLC ...
M. M. Baudarbekova
doaj +1 more source
, 2007 To maintain a tumour vasculature in proportion of the tumour growth, the endothelial cells proliferate and up-regulate the expression of the VEGF receptor 2 (VEGFR-2), whose expression is restricted to this cell type.
Waelti, Ernst +5 more
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Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges
British Journal of Pharmacology, EarlyView.This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu +6 more
wiley +1 more source