Results 111 to 120 of about 24,477,013 (226)
Cytoskeletal Dynamics in Cancer: From Pathogenesis to Treatment
MedComm, Volume 7, Issue 10, October 2026.This review systematically addresses the fundamental roles of the cytoskeleton (actin filaments, microtubules, and intermediate filaments) in cancer progression. We focus on how cytoskeletal dynamics regulate tumor proliferation, metastasis, and programmed cell death, while also modulating the immune microenvironment. Understanding these mechanisms may
Jie Chen +9 more
wiley +1 more source
Knockdown of Lv-VEGFR-10-Ig in PMCs reduces their ability to suppress BC transfating.
, 2019 (A) Experimental design. The entire complement of PMCs was removed from a recipient embryo and replaced with 15–40 RITC-labeled PMCs from control or Lv-VEGFR-10-Ig morphant donor embryos.
Ashrifia Adomako-Ankomah (7401002) +1 more
core +1 more source
Machine Learning‐Based Development of Gadolinium Binding Peptides
NMR in Biomedicine, Volume 39, Issue 10, October 2026.In this study, Dayan et al. employed a machine‐learning‐driven peptide‐evolution platform, the Protein Optimization Engineering Tool (POET), to design and optimize short Gd‐binding motifs to enhance longitudinal relaxivity (r1). ABSTRACT Gadolinium‐based contrast agents (GBCAs) are indispensable tools in magnetic resonance imaging (MRI), yet their ...
Nir A. Dayan +7 more
wiley +1 more source
Fruquintinib: Mechanism of Action, Clinical, and Translational Science
Clinical and Translational Science, Volume 19, Issue 10, October 2026.ABSTRACT Fruquintinib is a highly selective, oral inhibitor of all three vascular endothelial growth factor receptors (‐1, ‐2, and ‐3) that was approved, including in China, the United States, and the European Union, for the treatment of previously treated metastatic colorectal cancer (mCRC).
Xiaofei Zhou +7 more
wiley +1 more source
, 2010 Tumors induce new blood vessel growth primarily from host organ microvascular endothelial cells (EC), and microvasculature differs significantly between the lung and liver.
Daniel L. Karl +13 more
core +1 more source
International Endodontic Journal, Volume 59, Issue 10, Page 2143-2163, October 2026.ABSTRACT Background Dental pulp inflammation triggers immune responses involving macrophages and dental pulp stem cells (DPSCs), which interact to regulate angiogenesis essential for tissue repair. M1 pro‐inflammatory macrophages predominate early in pulpitis, and clarifying their angiogenic role is vital in identifying inflammatory regenerative ...
Dineshi Sewvandi Thalakiriyawa +5 more
wiley +1 more source
The Role of “Adult‐Onset” Cancer Predisposition Genes in Pediatric Cancer: A Comprehensive Review
Pediatric Blood &Cancer, Volume 73, Issue 9, September 2026.ABSTRACT Current literature estimates that 10% of pediatric cancers are caused by pathogenic or likely pathogenic (P/LP) germline variants in cancer predisposition genes (CPGs). Variants in CPGs thought to increase cancer risk exclusively during adulthood are referred to as “adult‐onset” CPGs (aoCPGs).
Maria Rozo +5 more
wiley +1 more source
ABL enhances VEGFR-2 internalization in ECs.
, 2016 A) Colocalization of VEGFR-2 with endosome markers EEA1 in ECs. The ECs were pretreated with ABL for 2 h following fifteen minutes of VEGF stimulation, fixed, permeablized, and labeled with anti-VEGFR-2 (red) and anti-EEA1 (green) and processed for ...
Jingshan Zhao (849409) +3 more
core +1 more source
Advanced Healthcare Materials, Volume 15, Issue 35, 18 September 2026.A bicistronic rAAV8 vector encoding Aflibercept (Afb) and COMP‐cAng1 simultaneously coordinates VEGF clearance and Tie2‐mediated vessel maturation. In a 3D angiogenesis‐on‐a‐chip model, rAAV8‐Afb/cAng1 effectively reverses pathological barrier breakdown under clinical disease‐mimicking challenges.
Bong‐Kyu Kim +9 more
wiley +1 more source
Advanced Materials, Volume 38, Issue 52, 16 September 2026.Extracellular vesicles (EVs) are cell‐derived nanoparticles that mediate intercellular communication through their dynamic biointerfaces. Owing to their intrinsic biological functions, EVs have emerged as promising platforms for biomedical applications.
Leila Pourtalebi Jahromi +3 more
wiley +1 more source