Results 101 to 110 of about 17,703,275 (296)

Causal Interplay Between Inflammatory Cytokines and Lipid Metabolites in Serous Ovarian Carcinoma: Insights From a Genetic Association Study

Journal of Clinical Laboratory Analysis, EarlyView.
This study utilizes a two‐sample Mendelian randomization framework to establish a causal link between circulating inflammatory proteins, blood metabolites, and the risk of serous ovarian carcinoma. Our findings identify Interleukin‐8 as a significant risk factor and demonstrate that 1‐Palmitoyl‐GPG (16:0) acts as a metabolic mediator within this ...
Chong‐ze Yang, Lan‐hui Qin, Cheng‐can Huang, Xiao‐li Huang, Ying‐xia Yang, Wei Lan, Miao Fan   +6 more
wiley   +1 more source

Cooperative and redundant roles of VEGFR-2 and VEGFR-3 signaling in adult lymphangiogenesis

Activation of vascular endothelial growth factor ( VEGF) receptor-3 (VEGFR-3) by VEGF-C initiates lymphangiogenesis by promoting lymphatic proliferation and migration.
Cui, Yingjie, Swartz, M. A., Hicklin, Daniel J., Pasquier, Miriella C., Rutkowski, Joseph M., Goldman, Jeremy, Shields, Jacqueline D., Schmoekel, Hugo G., Willey, Stephen, Pytowski, Bronislaw   +9 more
core   +1 more source

Differential Effects of VEGFR-1 and VEGFR-2 Inhibition on Tumor Metastases Based on Host Organ Environment

, 2010
Tumors induce new blood vessel growth primarily from host organ microvascular endothelial cells (EC), and microvasculature differs significantly between the lung and liver.
Daniel L. Karl, Rothrock, Courtney, D’Amore, Patricia A, Ryeom, Sandra, Yoon, Sam S, Sam S. Yoon, Sandra Ryeom, Patricia A. D'Amore, Lee, Yoon-Jin, Ugwuji N. Maduekwe, Courtney Rothrock, Maduekwe, Ugwuji N, Yoon-Jin Lee, Karl, Daniel L   +13 more
core   +1 more source

Stimulation of lymphangiogenesis via VEGFR-3 inhibits chronic skin inflammation [PDF]

, 2010
The role of lymphangiogenesis in inflammation has remained unclear. To investigate the role of lymphatic versus blood vasculature in chronic skin inflammation, we inhibited vascular endothelial growth factor (VEGF) receptor (VEGFR) signaling by function ...
Steven T. Proulx, Stefan Ullmann, Kari Alitalo, Alitalo, Kari, Detmar, Michael, Bronislaw Pytowski, Proulx, Steven T., Ullmann, Stefan, Reto Huggenberger, Pytowski, Bronislaw, Proulx, Steven T, Huggenberger, Reto, Michael Detmar   +12 more
core   +1 more source

PRDM1 Knockdown Promotes Ferroptosis and Sunitinib Sensitivity by Modulating the PI3K/Akt Signaling Through Inhibition of ESM1 Transcription in Renal Cell Carcinoma

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Renal cell carcinoma (RCC) is a commonly occurring and considerable burden on public health. Although chemotherapy benefits patients with advanced RCC, sunitinib resistance leads to a poor prognosis. Ferroptosis is also involved in sunitinib resistance in RCC.
Yi‐Shuai Zhang, Xin‐Qi Pei, Ji‐Ping Sun, Chen‐Hui Ma, Xin‐Yang Wang, Xu‐Dong Li   +5 more
wiley   +1 more source

Bioinformatics and computational studies of marine natural products in identifying novel VEGFR-2 inhibitors for breast cancer treatment

Results in Chemistry
Angiogenesis, a hallmark feature of cancer, is the process through which new blood vessels are formed from the preexisting vessels around the cancerous tissue.
Umar Yousuf, Humairah Tabasum, Urooj Un Nissa, Shazia Gul, Mushtaq A. Mir, Nasreena Bashir, Venkatramanan Varadharajan, Tanvir Ul Hassan Dar, Masood Ahmad Rizvi, Basharat Ahmad Bhat   +9 more
doaj   +1 more source

Dissecting VEGFR-2 and VEGFR-3 function : VEGFR-3 mediates lymphangiogenic signals

, 2002
ei ...
Veikkola, Tanja
core  

CLEC14A correlates with neutrophil infiltration in hepatocellular carcinoma and mediates neutrophil recruitment across liver endothelial cells

The Journal of Pathology, EarlyView.
Abstract Hepatocellular carcinoma (HCC) is a leading cause of cancer‐related deaths globally, and cases are predicted to rise dramatically over the next few years. Overcoming the immune microenvironment in HCC remains a challenge, and innate immune populations such as tumour‐associated neutrophils can potentially impair the success of immunotherapy ...
Joanne M O'Rourke, Dean Kavanagh, Ayla O'Keeffe, Kylie Savoye, Kaiyi Yang, Daniel A Patten, Catherine E Willoughby, Josep M Llovet, Georgiana Neag, Helen L Reeves, Peter W Hewett, Neena Kalia, Tahir Shah, Yuk Ting Ma, Kelly Hunter, Joe Flint, Jack L McMurray, Owen Cain, Fabian Spill, Derek A Mann, Amy J Naylor, Victoria Heath, Christopher J Weston, Roy Bicknell, Shishir Shetty   +24 more
wiley   +1 more source

From Deep Learning to the Discovery of Promising VEGFR‐2 Inhibitors

ChemMedChem
AbstractVascular endothelial growth factor receptor 2 (VEGFR‐2) stands as a prominent therapeutic target in oncology, playing a critical role in angiogenesis, tumor growth, and metastasis. FDA‐approved VEGFR‐2 inhibitors are associated with diverse side effects. Thus, finding novel and more effective inhibitors is of utmost importance. In this study, a
Mehmet Ali Yucel, Ercan Adal, Mine Buga Aktekin, Ceylan Hepokur, Nicola Gambacorta, Orazio Nicolotti, Oztekin Algul   +6 more
openaire   +2 more sources

Biomarkers to predict outcomes in diabetic foot ulcers

VIEW, EarlyView.
Studies attempting to predict the healing outcome of diabetic foot ulcers (DFUs) have investigated various biological materials and recovered molecules that may aid in discriminating wounds that will heal and those that will not heal. This graphical abstract captures the commonly studied classes of biomarkers in the context of DFUs.
Julie Okiro, Kellie Fortune, Eimear Daly, Luca McCann, Merhan Soltan, Seamus Sreenan, Fabio Quondamatteo   +6 more
wiley   +1 more source