Results 71 to 80 of about 24,477,013 (226)
Activation of VEGFR-1 and VEGFR-2 by UVA involves activation of PKC and SFK.
, 2013 (a) Western blotting detection of P-VEGFR-1 and P-VEGFR-2 in keratinocytes 12 h after treatment of 10 J/cm2 UVA with or without pre-incubation of Go6976 (0.5 µM), or rottlerin (5.0 µM) for 1 h. (b) The densitometric analysis of P-VEGFR-1 and P-VEGFR-2 in
Zhong-Fa Lu (285979) +5 more
core +1 more source
Arquivos Brasileiros de Cardiologia, 2018 Background: Pioglitazone has been widely used as an insulin-sensitizing agent for improving glycemic control in patients with type 2 diabetes mellitus. However, cardiovascular risk and protective effects of pioglitazone remain controversial. Objectives:
Wenliang Zhong +6 more
doaj +1 more source
iMeta, EarlyView.The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li +29 more
wiley +1 more source
Expression of VEGF-C and activation of its receptors VEGFR-2 and VEGFR-3 in trophoblast [PDF]
, 2011 Placental villous development requires the co-ordinated action of angiogenic factors on both endothelial and trophoblast cells. Like vascular endothelial growth factor (VEGF), VEGF-C increases vascular permeability, stimulates endothelial cell ...
Dunk, C., Ahmed, As¡ S.
core +2 more sources
iNew Medicine, EarlyView.ABSTRACT Ovarian cancer (OC) continues to be the deadliest gynecological malignancy and a significant cause of cancer‐related mortality among women worldwide. Standard treatment strategies typically entail platinum‐based chemotherapy in conjunction with cytoreductive surgery.
Zunera Khalid +4 more
wiley +1 more source
The Endothelial CXCR Family in Vascular Health and Disease
iNew Medicine, EarlyView.ABSTRACT Endothelial cells (ECs) form the dynamic interface between blood and tissue, serving as key regulators of vascular homeostasis, inflammation, and repair. Among the molecular systems governing endothelial behavior, the C‐X‐C motif chemokine receptor (CXCR) family—originally characterized in immunology for its roles in leukocyte trafficking and ...
Zhiming Wu +4 more
wiley +1 more source
VEGFR-2 conformational switch in response to ligand binding
eLife, 2016 VEGFR-2 is the primary regulator of angiogenesis, the development of new blood vessels from pre-existing ones. VEGFR-2 has been hypothesized to be monomeric in the absence of bound ligand, and to undergo dimerization and activation only upon ligand ...
Sarvenaz Sarabipour +2 more
doaj +1 more source
Gene expression of VEGFR–1 and VEGFR–2 in HD1 and HD2.
, 2022 Median and standard error of gene expression of VEGFR–1 and VEGFR–2 at all points of investigation in native ECs of HD1 and HD2 are shown.
Christina Herre (12475755) +4 more
core +1 more source
The FGF/FGFR System in the Biology and Therapeutic Landscape of Pediatric CNS Tumors
Medicinal Research Reviews, EarlyView.ABSTRACT Central nervous system (CNS) tumors are the most common solid malignancies in children, comprising a highly heterogeneous group of neoplasms defined by distinct molecular alterations and clinical behaviors. Advances in molecular genetics have underscored the relevance of specific signaling pathways in driving pediatric tumorigenesis, among ...
Serena Filiberti +6 more
wiley +1 more source
Scientific ReportsCervical cancer stands as a prevalent gynaecologic malignancy affecting women globally, often linked to persistent human papillomavirus infection. Biomarkers associated with cervical cancer, including VEGF-A, VEGF-B, VEGF-C, VEGF-D, and VEGF-E, show ...
Anuraj Nayarisseri +12 more
doaj +1 more source