Results 71 to 80 of about 17,703,275 (296)

The role of heterodimerization between VEGFR-1 and VEGFR-2 in the regulation of endothelial cell homeostasis [PDF]

, 2012
VEGF-A activity is tightly regulated by ligand and receptor availability. Here we investigate the physiological function of heterodimers between VEGF receptor-1 (VEGFR-1; Flt-1) and VEGFR-2 (KDR; Flk-1) (VEGFR(1-2)) in endothelial cells with a synthetic ...
Cudmore, Melissa J., Gu, Yuchun, Barleon, Bernhard, Hewett, Peter W, Al-Ani, Bahjat, Newby, David E., Cudmore, Melissa J, Fujisawa, Takeshi; id_orcid, Weich, Herbert, Hewett, Peter, Newby, David E, Sissaoui, Samir, Ahmed, Asif, Hewett, Peter W., Wang, Ke-Qing, Cai, Meng, Miller, Mark R., Ramma, Wenda, Fujisawa, Takeshi, Ahmad, Shakil, Miller, Mark R, Ma, Bin   +21 more
core   +1 more source

From anthelmintic to neuro‐oncology: A systematic review of mebendazole repurposing for brain tumour therapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum, Milli McMenamin, Tessa Khoo, John M. Edwin, Prathibha Jose, Liam A. O’Callaghan   +5 more
wiley   +1 more source

Single nucleotide polymorphisms: rs833061, rs699947, and rs35569394, and the expression of the vascular endothelial growth factor gene in Moroccan patients with lung cancer [PDF]

Exploration of Medicine
Aim: Angiogenesis is a universal hallmark of all cancers involving a variety of proteins including vascular endothelial growth factor (VEGF). Extensive studies have explored the potential implications of single nucleotide polymorphisms (SNPs) within VEGF-
Younes El Founini, Sara Hafidi, Hind Dehbi, Mohammed Attaleb, Mehdi Karkouri, Souheil Boubia, Mohammed Ridai, Fadila Guessous, Mohammed El Mzibri, Imane Chaoui   +9 more
doaj   +1 more source

Prognostic roles of cross-talk between peritumoral hepatocytes and stromal cells in hepatocellular carcinoma involving peritumoral VEGF-C, VEGFR-1 and VEGFR-3. [PDF]

PLoS ONE, 2013
BACKGROUND: Peritumoral liver tissue could play a potential role in hepatocellular carcinoma (HCC) progression and patient survival via angiogenesis- and lymphangiogensis-related factors.
Peng-Yuan Zhuang, Jun Shen, Xiao-Dong Zhu, Lu Lu, Lu Wang, Zhao-You Tang, Hui-Chuan Sun   +6 more
doaj   +1 more source

Cold atmospheric plasma‐mediated tumor microenvironment remodeling for cancer treatment

BMEMat, EarlyView.
Schematic presentation of CAP‐mediated TME remodeling. This review summarizes recent efforts in cold atmospheric plasma (CAP) application in cancer treatment, highlighting the anticancer potential of CAP, molecular mechanisms, and future perspectives for further improvement and clinical translation.
Israr Khan, Qiujie Fang, Cao Fei, Ziyuan Wang, Zhaowei Chen, Guojun Chen, Zhiming Xu, Shu Xu, Zhitong Chen   +8 more
wiley   +1 more source

The rs2071559 AA VEGFR-2 Genotype Frequency Is Significantly Lower in Neovascular Age-Related Macular Degeneration Patients

The Scientific World Journal, 2012
In this prospective, case-control genetic study, 120 consecutive neovascular age-related macular degeneration (AMD) cases and 78 controls were enrolled.
Stefano Lazzeri, Paola Orlandi, Michele Figus, Anna Fioravanti, Elisa Cascio, Teresa Di Desidero, Elisa Agosta, Bastianina Canu, Maria Sole Sartini, Romano Danesi, Marco Nardi, Guido Bocci   +11 more
doaj   +1 more source

Modulation of Receptor Tyrosine Kinase Activity through Alternative Splicing of Ligands and Receptors in the VEGF-A/VEGFR Axis

Cells, 2019
Vascular endothelial growth factor A (VEGF-A) signaling is essential for physiological and pathological angiogenesis. Alternative splicing of the VEGF-A pre-mRNA gives rise to a pro-angiogenic family of isoforms with a differing number of amino acids ...
Megan Stevens, Sebastian Oltean
doaj   +1 more source

Activation of VEGFR-1 and VEGFR-2 by UVA involves activation of PKC and SFK.

, 2013
(a) Western blotting detection of P-VEGFR-1 and P-VEGFR-2 in keratinocytes 12 h after treatment of 10 J/cm2 UVA with or without pre-incubation of Go6976 (0.5 µM), or rottlerin (5.0 µM) for 1 h. (b) The densitometric analysis of P-VEGFR-1 and P-VEGFR-2 in
Zhong-Fa Lu (285979), Sui-Qing Cai (285980), Jian-Wei Zhu (285977), Dan Luo (192943), Xian-Jie Wu (285978), Min Zheng (131026)   +5 more
core   +1 more source

AKT, ATR, and Notch Inhibitors Radiosensitize a Preclinical Model of Adenoid Cystic Carcinoma

Head &Neck, EarlyView.
ABSTRACT Background Adenoid Cystic Carcinoma (ACC) is a rare and lethal type of head and neck cancer. Standard therapy involves surgery followed by radiation therapy. The majority of ACC has MYB overexpression and MYB‐NFIB gene fusions, while Notch mutations are associated with aggressive behavior.
Shivani Thoidingjam, Sushmitha Sriramulu, Asya Haider Muratoglu, Stephen Brown, Oudai Hassan, Benjamin Movsas, Haythem Ali, Steven Chang, Patrick Ha, Farzan Siddiqui, Shyam Nyati   +10 more
wiley   +1 more source

UVA promoted tyrosine phosphorylation of VEGFR-1 and VEGFR-2 in normal human keratinocytes.

, 2013
(a) The time-dependent phosphorylation of VEGFR-1 and VEGFR-2 in keratinocytes induced by 10 J/cm2 UVA. Cells were harvested 0, 2, 4, 8, 12, 24 h after irradiation. (b) The densitometric analysis of (a).
Zhong-Fa Lu (285979), Sui-Qing Cai (285980), Jian-Wei Zhu (285977), Dan Luo (192943), Xian-Jie Wu (285978), Min Zheng (131026)   +5 more
core   +1 more source