Results 21 to 30 of about 94,145 (264)

New Insights into a Three-Sub-Step Composite Method and Its Performance on Multibody Systems

Mathematics, 2022
This paper develops a new implicit solution procedure for multibody systems based on a three-sub-step composite method, named TTBIF (trapezoidal–trapezoidal backward interpolation formula).
Yi Ji, Huan Zhang, Yufeng Xing
doaj   +1 more source

Dynamic traffic assignment for electric vehicles

Transportation Research Part B: Methodological, 2022
We initiate the study of dynamic traffic assignment for electrical vehicles addressing the specific challenges such as range limitations and the possibility of battery recharge at predefined charging locations. We pose the dynamic equilibrium problem within the deterministic queueing model of Vickrey and as our main result, we establish the existence ...
Lukas Graf, Tobias Harks, Prashant Palkar   +2 more
openaire   +5 more sources

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Midcourse Guidance Law Based on High Target Acquisition Probability Considering Angular Constraint and Line-of-Sight Angle Rate Control

International Journal of Aerospace Engineering, 2016
Random disturbance factors would lead to the variation of target acquisition point during the long distance flight. To acquire a high target acquisition probability and improve the impact precision, missiles should be guided to an appropriate target ...
Xiao Liu, Shengjing Tang, Jie Guo, Yuhang Yun, Zhe Chen   +4 more
doaj   +1 more source

Modelling the vehicle in vehicle—infrastructure dynamic interaction studies [PDF]

Proceedings of the Institution of Mechanical Engineers, Part K: Journal of Multi-body Dynamics, 2009
This article presents the equations of motion for a general articulated road vehicle, with variable number of wheels for the tractor and trailer. The equations are applicable to vehicle—infrastructure dynamic interaction problems for two- and three-dimensional systems, allowing for the definition of a wide variety of vehicle configurations with the ...
Cantero, Daniel, O'Brien, Eugene J., González, Arturo   +2 more
openaire   +3 more sources

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Broadband dual-anisotropic solid metamaterials

Scientific Reports, 2017
We have proposed solid elastic metamaterials with anisotropic stiffness and inertial mass simultaneously, denoted as the dual anisotropy, for the potential use of elastic wave controlling.
Yong Cheng, Xiaoming Zhou, Gengkai Hu
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Eigenvalue sensitivity analysis based on the transfer matrix method

International Journal of Mechanical System Dynamics, 2021
For linear mechanical systems, the transfer matrix method is one of the most efficient modeling and analysis methods. However, in contrast to classical modeling strategies, the final eigenvalue problem is based on a matrix which is a highly nonlinear ...
Dieter Bestle
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source