Results 31 to 40 of about 4,113,138 (281)

Midcourse Guidance Law Based on High Target Acquisition Probability Considering Angular Constraint and Line-of-Sight Angle Rate Control

International Journal of Aerospace Engineering, 2016
Random disturbance factors would lead to the variation of target acquisition point during the long distance flight. To acquire a high target acquisition probability and improve the impact precision, missiles should be guided to an appropriate target ...
Xiao Liu, Shengjing Tang, Jie Guo, Yuhang Yun, Zhe Chen   +4 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Modelling of suspension components in a rail vehicle dynamics context

, 2011
Suspension components play key roles in the running behaviour of rail vehicles, and therefore, mathematical models of suspension components are essential ingredients of railway vehicle multi-body models.
Jordi Vinolas, Sebastian Stichel, Bruni, Stefano, Polach, Oldrich, Stichel, Sebastian,, Vinolas, Jordi, Berg, Mats,, Oldrich Polach, Stefano Bruni, Mats Berg   +9 more
core   +1 more source

Broadband dual-anisotropic solid metamaterials

Scientific Reports, 2017
We have proposed solid elastic metamaterials with anisotropic stiffness and inertial mass simultaneously, denoted as the dual anisotropy, for the potential use of elastic wave controlling.
Yong Cheng, Xiaoming Zhou, Gengkai Hu
doaj   +1 more source

Modelling the vehicle in vehicle—infrastructure dynamic interaction studies [PDF]

Proceedings of the Institution of Mechanical Engineers, Part K: Journal of Multi-body Dynamics, 2009
This article presents the equations of motion for a general articulated road vehicle, with variable number of wheels for the tractor and trailer. The equations are applicable to vehicle—infrastructure dynamic interaction problems for two- and three-dimensional systems, allowing for the definition of a wide variety of vehicle configurations with the ...
Cantero, Daniel, O'Brien, Eugene J., González, Arturo   +2 more
openaire   +3 more sources

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

2022 Vehicle Dynamics seminar [Elektronisk resurs]

, 2022
The seminar is held annually. The full title of this year's seminar was "2021 Vehicle Dynamics seminar -- Connected and Electric"
Drugge, Lars,, Jacobson, Bengt J H,, Bruzelius, Fredrik,   +2 more
core  

Eigenvalue sensitivity analysis based on the transfer matrix method

International Journal of Mechanical System Dynamics, 2021
For linear mechanical systems, the transfer matrix method is one of the most efficient modeling and analysis methods. However, in contrast to classical modeling strategies, the final eigenvalue problem is based on a matrix which is a highly nonlinear ...
Dieter Bestle
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source