Results 51 to 60 of about 698,039 (294)

Dynamic Modeling and Analysis of Nonlinear Compound Planetary System

Machines, 2022
In the vehicle composite planetary gear transmission system, nonlinear excitations such as time-varying meshing stiffness, backlash and comprehensive error would lead to large vibration and noise, uneven load distribution, unstable operation and other ...
Tingqiong Cui, Yinong Li, Chenglin Zan, Yuanchang Chen   +3 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Intrinsic Optimal Control for Mechanical Systems on Lie Group

Advances in Mathematical Physics, 2017
The intrinsic infinite horizon optimal control problem of mechanical systems on Lie group is investigated. The geometric optimal control problem is built on the intrinsic coordinate-free model, which is provided with Levi-Civita connection.
Chao Liu, Shengjing Tang, Jie Guo
doaj   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Geometric Controls for a Tethered Quadrotor UAV

, 2015
This paper deals with the dynamics and controls of a quadrotor unmanned aerial vehicle that is connected to a fixed point on the ground via a tether. Tethered quadrotors have been envisaged for long-term aerial surveillance with high-speed communications.
Lee, Taeyoung
core   +1 more source

Analysis and design of a capsule landing system and surface vehicle control system for Mars exploration [PDF]

Problems related to the design and control of a mobile planetary vehicle to implement a systematic plan for the exploration of Mars are reported. Problem areas include: vehicle configuration, control, dynamics, systems and propulsion; systems analysis ...
Frederick, D. K., Lashmet, P. K., Sandor, G. N., Shen, C. N., Smith, E. V., Yerazunis, S. W.   +5 more
core   +4 more sources

Basic study on vertical vibrations suppression in railway vehicle carbody by secondary suspension control using bogie vertical vibration velocity

Nihon Kikai Gakkai ronbunshu
This study investigates a new method for the effective application of active secondary suspension for reducing vertical vibration of the carbody to improve ride comfort of railway vehicles.
Yoshiki SUGAHARA, Ayumi AMANO
doaj   +1 more source

Proposal for objective evaluation criteria for steering feel by steering torque sinusoidal input

Nihon Kikai Gakkai ronbunshu, 2017
The steering feel is an important technical problem for handling and drivability of driver-vehicle system and various kinds of studies have been conducted.
Ikuo KUSHIRO, Keisuke SUZUKI
doaj   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Analysis for vehicle dynamics and steering system parameters effect on steering characteristics of steering feel (Fundamental study for performance design of objective target on steering feel)

Nihon Kikai Gakkai ronbunshu, 2017
The purpose of this paper is to clarify the effect of vehicle dynamics and steering system parameter on steering feel. The objective evaluation method for on-center and off-center evaluates steering effort, steering torque gradient, torque hysteresis and
Ikuo KUSHIRO, Keisuke SUZUKI
doaj   +1 more source