Results 61 to 70 of about 4,113,138 (281)

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

Analysis for vehicle dynamics and steering system parameters effect on steering characteristics of steering feel (Fundamental study for performance design of objective target on steering feel)

Nihon Kikai Gakkai ronbunshu, 2017
The purpose of this paper is to clarify the effect of vehicle dynamics and steering system parameter on steering feel. The objective evaluation method for on-center and off-center evaluates steering effort, steering torque gradient, torque hysteresis and
Ikuo KUSHIRO, Keisuke SUZUKI
doaj   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Parametrisation of a Maxwell model for transient tyre forces by means of an extended firefly algorithm

Advances in Mechanical Engineering, 2016
Developing functions for advanced driver assistance systems requires very accurate tyre models, especially for the simulation of transient conditions. In the past, parametrisation of a given tyre model based on measurement data showed shortcomings, and ...
Andreas Hackl, Wolfgang Hirschberg, Cornelia Lex, Christian Magele   +3 more
doaj   +1 more source

Augmenting and Assaying Nav1.1 Protein Quantity for Dravet Syndrome Therapy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Dravet Syndrome (DS) is a developmental and epileptic encephalopathy predominantly caused by heterozygous loss‐of‐function variants in SCN1A, which encodes Nav1.1. Conserved upstream open reading frames (uORFs) in SCN1A were validated to regulate translation in reporter assays, demonstrating the therapeutic viability of increasing Nav1.1 from ...
Aiswarya Saravanan, Jordan Safran, Anna Loughman, Grace Lin, Shivanshi Vaid, Dana Allababidi, Peter M. Tessier, Louis T. Dang   +7 more
wiley   +1 more source

Robust Static Output Feedback Control of a Semi-Active Vehicle Suspension Based on Magnetorheological Dampers

Applied Sciences
This paper proposes a novel design method for a magnetorheological (MR) damper-based semi-active suspension system. An improved MR damper model that accurately describes the hysteretic nature and effect of the applied current is presented.
Fernando Viadero-Monasterio, Miguel Meléndez-Useros, Manuel Jiménez-Salas, Beatriz López Boada   +3 more
doaj   +1 more source

A Q‐Learning Algorithm to Solve the Two‐Player Zero‐Sum Game Problem for Nonlinear Systems

International Journal of Adaptive Control and Signal Processing, Volume 39, Issue 3, Page 566-581, March 2025.
A Q‐learning algorithm to solve the two‐player zero‐sum game problem for nonlinear systems. ABSTRACT This paper deals with the two‐player zero‐sum game problem, which is a bounded L2$$ {L}_2 $$‐gain robust control problem. Finding an analytical solution to the complex Hamilton‐Jacobi‐Issacs (HJI) equation is a challenging task.
Afreen Islam, Anthony Siming Chen, Guido Herrmann   +2 more
wiley   +1 more source

Numerical methods in vehicle system dynamics: state of the art and current developments

, 2011
Robust and efficient numerical methods are an essential prerequisite for the computer based dynamical analysis of engineering systems. In vehicle system dynamics, the methods and software tools from multibody system dynamics provide the integration ...
Arnold, Martin, Führer, Claus,, Hippmann, Gerhard, Rill, Georg, Lund University., Burgermeister, Bernhard   +5 more
core   +1 more source

Avoiding Lyapunov-Krasovskii Functionals: Simple Nonlinear Sampled–Data Control of a Semi-Active Suspension with Magnetorheological Dampers

Machines
This paper presents a novel control design methodology for a magnetorheological (MR) damper-based semi-active suspension system operating under communication-induced time delays, which introduce nonlinear sampled-data dynamics.
Fernando Viadero-Monasterio, Miguel Meléndez-Useros, Manuel Jiménez-Salas, María Jesús López Boada   +3 more
doaj   +1 more source

Air‐Pressure–Actuated Vibroacoustic Metamaterial With Tunable Bandgap: Design, Modeling, and Characterization

Advanced Engineering Materials, EarlyView.
This article presents the design, modeling, and characterization of air‐pressure–actuated programmable vibroacoustic metamaterials (PVAMM). The study focuses on leveraging air pressure to dynamically tune resonance frequencies for effective noise attenuation.
William Kaal, Michael M. Becker, Sarah C. L. Fischer   +2 more
wiley   +1 more source