Results 81 to 90 of about 2,427 (259)

A synthetic biology approach for consistent production of plant-made recombinant polyclonal antibodies against snake venom toxins [PDF]

, 2018
Antivenoms developed from the plasma of hyperimmunized animals are the only effective treatment available against snakebite envenomation but shortage of supply contributes to the high morbidity and mortality toll of this tropical disease.
Arnold, Beerli, Bendandi, Bolanos, Chippaux, Elena, Frauches, Gene, Graham, Gutierrez, Gutierrez, Gutierrez, Gutierrez, Gutierrez, Gutierrez, Gutierrez, Harrison, Julve, Laustsen, Laustsen, Lavonas, Marillonnet, Marillonnet, Paul, Paul, Pla, Qiu, Ramos, Rasmussen, Sarrion-Perdigones, Segura, Soller, Stock, Stoger, Syller, Theakston, Walwyn, Wang, Zheng   +38 more
core   +2 more sources

Open‐land‐derived agroforestry and effects of abandonment of management of the main crop on ecosystem services and woody plant diversity

PLANTS, PEOPLE, PLANET, EarlyView.
Tropical forests are rapidly declining. One promising strategy to reverse the loss of tropical forest is the establishment of agroforestry on open land. We combined interviews with biodiversity surveys to learn general lessons from success and nonsuccess stories of the establishment of open‐land‐derived coffee agroforests in one of the world's ...
Lucas M. Fonzaghi, Kristoffer Hylander, Thiago S. de Melo, Ayco J. M. Tack   +3 more
wiley   +1 more source

Venom-derived peptides for breaking through the glass ceiling of drug development

Frontiers in Chemistry
Venoms are complex mixtures produced by animals and consist of hundreds of components including small molecules, peptides, and enzymes selected for effectiveness and efficacy over millions of years of evolution.
Lou Freuville, Chloé Matthys, Loïc Quinton, Jean-Pierre Gillet   +3 more
doaj   +1 more source

Bioinformatics‐Driven Design and Evaluation of Recombinant Multi‐Epitope Immunogens Derived From Snake Venom Toxins as Potential Antivenom Candidates

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Snakebite envenomation is a major public health concern, particularly in low‐ and middle‐income regions where access to safe and effective antivenoms is limited. Traditional antivenoms, derived from immunization with crude venom, often trigger adverse reactions and lack specificity against key venom components.
Hanan Maoz, Amir Elalouf
wiley   +1 more source

An Economic Dilemma between Molecular Weapon Systems May Explain an Arachno-Atypical Venom in Wasp Spiders (Argiope bruennichi)

Biomolecules, 2020
Spiders use venom to subdue their prey, but little is known about the diversity of venoms in different spider families. Given the limited data available for orb-weaver spiders (Araneidae), we selected the wasp spider Argiope bruennichi for detailed ...
Tim Lüddecke, Björn M. von Reumont, Frank Förster, André Billion, Thomas Timm, Günter Lochnit, Andreas Vilcinskas, Sarah Lemke   +7 more
doaj   +1 more source

Lecanicillium aphanocladii: a biocontrol agent against insect pests and phytopathogens

Pest Management Science, EarlyView.
Recent research findings on the biocontrol potential of Lecanicillium aphanocladii fungus against insect‐pests and plant diseases were highlighted. This review indicates that several L. aphanocladii strains show great potential to be developed as multipurpose biocontrol agents active against several insect‐pests, plant diseases and plant parasitic ...
Qianhe Liu, Richard Johnson, Kwasi Adusei‐Fosu   +2 more
wiley   +1 more source

Characterisation of three alpha-helical antimicrobial peptides from the venom of Scorpio maurus palmatus. [PDF]

, 2016
Scorpion venoms provide a rich source of anti-microbial peptides. Here we characterise three from the venom of Scorpion maurus palmatus. Smp13 is biologically inactive, despite sharing homology with other antimicrobial peptides, probably because it lacks
Abdel-Rahman, Andrews, Bahar, Baumann, Bobone, Calvete, Corzo, Dai, Dempsey, Gajski, Galanth, Glukhov, Hancock, Harrison, Hilliard, Holak, Huang, Jenssen, Jiang, Kaduk, Keith Miller, Kobayashi, Livermore, Ludtke, Matsuzaki, Melo, Moerman, Mohamed A. Abdel-Rahman, Mohamed M. Tawfik, Nelson, Nomura, Nomura, Park, Park, Patrick L. Harrison, Peter N. Strong, Powers, Rodríguez, Rodríguez, Shai, Shin, Sreerama, Teixeira, Torres-Larios, Urban, Whitmore, Yamaguchi, Yeaman, Yonezawa, Zasloff, Zasloff, Zeng, Zhang   +52 more
core   +1 more source

Potential targets for renal cell carcinoma therapy: Mechanistic research and prospects of CAFs in renal cell carcinoma

VIEW, EarlyView.
Cancer‐associated fibroblasts exert intricate mechanisms in the progression and metastasis of renal cell carcinoma. Existing studies have validated the relevant mechanisms of three signaling pathways, which hold promising potential as novel therapeutic targets.
Ruiqiang Sun, Jiankun Zhang, Meixi Liu, Xiyue Dong, Yuanshan Cui   +4 more
wiley   +1 more source

A Polychaete’s Powerful Punch: Venom Gland Transcriptomics of Glycera Reveals a Complex Cocktail of Toxin Homologs [PDF]

, 2014
© The Author(s) 2014. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/
Abdel-Rahman, Aird, Alarcon-Chaidez, Altschul, Alves-Silva, Ambrose, Anatriello, Anderluh, Bakrac, Bakrac, Balasubramanian, Barlic, Binford, Binford, Björn M. von Reumont, Bon, Borda, Bradnam, Brinkman, Böggemann, Casewell, Castaneda, Castaneda, Chagas, Chang, Chen, Christoph Bleidorn, Conesa, Conesa, Cuypers, Dan Sykes, Darriba, De Colibus, Earl, Eddy, Fauchald, Favreau, Fernandes-Pedrosa, Francischetti, Fry, Fry, Garb, Garcia, Garcia-Ortega, Ghadessy, Giese, Giray, Grabherr, Hargreaves, He, Honma, Jungo, Jörg Hetmank, Kagan, Katoh, Kawashima, Khalturin, King, King, Kircher, Kiriake, Klawe, Kobayashi, Koua, Krebs, Kristan, Kvist, Lahcen I. Campbell, Lars Hering, Lin, Low, Low, Manaranche, Mancheno, Margres, Martin, Meunier, Meunier, Meyer, Michel, Michel, Min, Morgenstern, Morgenstern, Moses, Nakamura, Olivera, O’Neil, Peng, Pennington, Petersen, Rangaraju, Rigoni, Rokyta, Ronald A. Jenner, Rosenberg, Rouse, Safavi-Hemami, Sandy Richter, Schenning, Shiomi, Shiomi, Smeds, Stamatakis, Sukumwang, Sunagar, Terrat, Ueda, Ungerer, Violette, von Reumont, Vonk, Warren, Watala, Weston, Whittington, Wong, Zdobnov, Zhang, Zimmerberg, Zobel-Thropp   +120 more
core   +1 more source

Structure and composition of supported lipid bilayers: a comparison between solvent‐assisted lipid bilayer and vesicle fusion methods

Journal of Applied Crystallography, EarlyView.
Neutron reflectometry is used to compare supported lipid bilayers formed by vesicle fusion and solvent‐assisted lipid bilayer (SALB) methods, revealing structurally comparable architectures with minor differences in acyl chain thickness and low residual solvent incorporation.
Birgit Felderer, Claire Buchanan, Shuhong Wang, Hsin-Hui Shen, Andrew Nelson, Stephen C. L. Hall, Marité Cárdenas   +6 more
wiley   +1 more source