PROTECTIVE EFFECTS OF VERAPAMIL AGAINST HEXACHLOROBUTADIENE NEPHROTOXICITY IN RATS [PDF]
Pakistan Veterinary Journal, 2008 In order to evaluate the protective effect of verapamil against hexachlorobutadiene (HCBD) nephrotoxicity, 30 adult Wistar albino rats were divided into five equal groups, A, B, C, D and E and were given intra-peritonially corn oil (I ml/kg; control ...
E. MOGHTADAI KHORASGANI, K. MANOCHEHRI AND M. HOSSEINI1
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PLoS ONE, 2021 The global incidence of diabetes mellitus (DM) is increasing. Types 1 and 2 DM are associated with declining β-cell function. Verapamil (50% S-verapamil and 50% R-verapamil) can treat DM by downregulating thioredoxin-interacting protein (TXNIP), which ...
Yu-Syuan Chen +8 more
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Pharmaceutical Biology, 2022 Context Solanaceae glycoalkaloids (SGAs) possess cardiomodulatory activity.Objective This study investigated the potential interaction between verapamil and glycoalkaloids.Material and methods The cardioactivity of verapamil and glycoalkaloids (α ...
Szymon Chowański +9 more
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Effect of calcium channel blocker on steroid hormone profile of primary cultured aldosterone producing adenoma cells [PDF]
Jichu yixue yu linchuang, 2022 Objective To explore the influence of calcium channel blocker(CCB), verapamil, on steroid hormone profile of primary cultured aldosterone producing adenoma(APA)cells.
GAO Yin-jie, YU Song-lin, YIN Yi-cong, CUI Yun-ying, ZHANG Yu-shi, QIU Ling, TONG An-li
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The cardiac work-loop technique:An in vitro model for identifying and profiling drug-induced changes in inotropy using rat papillary muscles [PDF]
, 2020 The cardiac work-loop technique closely mimics the intrinsic in vivo movement and characteristics of cardiac muscle function. In this study, six known inotropes were profiled using the work-loop technique to evaluate the potential of this method to ...
AJ Taberner +56 more
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Journal of Tehran University Heart Center, 2022 Background: The trans-radial approach significantly reduces access bleeding and underlying vascular complications and is associated with lower healthcare costs than the transfemoral approach.
Mohammadreza Beyranvand +3 more
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Anti-arrhythmic effect of verapamil is accompanied by preservation of cx43 protein in rat heart. [PDF]
PLoS ONE, 2013 The present study was to test the hypothesis that anti-arrhythmic properties of verapamil may be accompanied by preserving connexin43 (Cx43) protein via calcium influx inhibition.
Peng Zhou +5 more
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Effect of verapamil on the pharmacokinetics of hydroxycamptothecin and its potential mechanism
Pharmaceutical Biology, 2020 Context Hydroxycamptothecin (HCPT) has antitumor activity in various cancers, but its poor bioavailability and efflux limit its clinical application. Verapamil has been demonstrated to improve the bioavailability of many drugs.
Hua Xing +6 more
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Verapamil protects against cartilage degradation in osteoarthritis by inhibiting Wnt/β-catenin signaling. [PDF]
PLoS ONE, 2014 In past years, the canonical Wnt/β-catenin signaling pathway has emerged as a critical regulator of cartilage development and homeostasis. FRZB, a soluble antagonist of Wnt signaling, has been studied in osteoarthritis (OA) animal models and OA patients ...
Akira Takamatsu +6 more
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Mechanism Underlying the Reversal of Drug Resistance in P-Glycoprotein-Expressing Leukemia Cells by Pinoresinol and the Study of a Derivative [PDF]
, 2017 P-glycoprotein (P-gp) is a membrane protein associated with multidrug resistance (MDR) due to its key role in mediating the traffic of chemotherapeutic drugs outside cancer cells, leading to a cellular response that hinders efforts toward successful ...
Carpinella, Maria Cecilia +10 more
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