Results 121 to 130 of about 101,449 (340)

Verapamil inhibits calcification and matrix vesicle activity of bovine vascular smooth muscle cells [PDF]

, 2010
Calcium channel activity in vascular smooth muscle cells is a critical component during vascular calcification and formation of matrix vesicles. Here, we examined whether the blockade of L-type calcium channels inhibits these functions.
Chen, Neal X., Chen, Xianming, Kircelli, Fatih, Moe, Sharon M., O'Neill, Kalisha D.   +4 more
core   +1 more source

Efflux Inhibition with Verapamil Potentiates Bedaquiline in Mycobacterium tuberculosis

Antimicrobial Agents and Chemotherapy, 2013
Drug efflux is an important resistance mechanism in Mycobacterium tuberculosis. We found that verapamil, an efflux inhibitor, profoundly decreases the MIC of bedaquiline and clofazimine to M. tuberculosis by 8- to 16-fold.
Shashank Gupta, K. Cohen, K. Winglee, M. Maiga, B. Diarra, W. Bishai   +5 more
semanticscholar   +1 more source

Clinical Assessment of the Drug–Drug Interaction Potential of Omaveloxolone in Healthy Adult Participants

The Journal of Clinical Pharmacology, EarlyView.
Abstract Omaveloxolone is approved in the United States and the European Union for the treatment of patients with Friedreich ataxia aged ≥16 years. It is mainly metabolized by cytochrome P450 (CYP) 3A4 in vitro. Two drug–drug interaction studies (NCT04008186 and NCT05909644) were performed to evaluate (1) the effect of drug‐metabolizing enzymes (DMEs ...
Hamim Zahir, Masako Murai, Lucy Wu, Michelle Valentine, Scott Hynes   +4 more
wiley   +1 more source

Osteoblast interactions within a biomimetic apatite microenvironment. [PDF]

, 2011
Numerous reports have shown that accelerated apatites can mediate osteoblastic differentiation in vitro and bone formation in vivo. However, how cells interact within the apatite microenvironment remains largely unclear, despite the vast literature ...
Arakawa, Christopher K, Tsang, Eric J, Wu, Benjamin M, Zuk, Patricia A   +3 more
core   +3 more sources

Things We Do for No Reason: Failing to consider primary aldosteronism in the initial evaluation of hypertension, hypertensive urgency, and hypertensive emergency

Journal of Hospital Medicine, EarlyView.
Abstract Hypertension is frequently treated as essential hypertension. However, secondary causes of hypertension should be considered, because distinct treatments are used for different causes of hypertension. Primary aldosteronism is considered a candidate for the most common cause of secondary hypertension.
Michael C. Shih, Tessa R. Lavorgna, Prerna Dogra, Christina N. Hirner, Kristen Payne   +4 more
wiley   +1 more source

Targeting cellular calcium homeostasis to prevent cytokine-mediated beta cell death [PDF]

, 2017
Pro-inflammatory cytokines are important mediators of islet inflammation, leading to beta cell death in type 1 diabetes. Although alterations in both endoplasmic reticulum (ER) and cytosolic free calcium levels are known to play a role in cytokine ...
Abreu, Damien, Clark, Amy L, Kanekura, Kohsuke, Lavagnino, Zeno, Mahadevan, Jana, Piston, David W, Semenkovich, Clay F, Spears, Larry D, Urano, Fumihiko, Yagi, Takuya   +9 more
core   +2 more sources

Verapamil Ameliorates Hepatic Metaflammation by Inhibiting Thioredoxin-Interacting Protein/NLRP3 Pathways

Frontiers in Endocrinology, 2018
Activation of thioredoxin-interacting protein (TXNIP)/nod-like receptor protein 3 (NLRP3) inflammasome plays a critical role in pathogenesis of non-alcoholic fatty liver disease.
Feng Zhou, Feng Zhou, Ying Zhang, Jing Chen, Yimeng Hu, Yancheng Xu   +5 more
doaj   +1 more source

Parathyroid Hormone Enhances Mechanically Induced Bone Formation, Possibly Involving L-Type Voltage- Sensitive Calcium Channels [PDF]

, 2003
PTH and mechanical loading might act synergistically on bone formation. We tested the in vivo effect of the L-type voltage-sensitive calcium channel (VSCC) blocker, verapamil, on bone formation induced by human PTH-(1–34) (PTH) injection with or without ...
Burr, David B., Duncan, Randall L, Gattone, Vincent H, Li, Jiliang, Turner, Charles H   +4 more
core   +1 more source

Mechanistic Physiologically Based Pharmacokinetic Modeling of Dry Powder and Nebulized Formulations of Orally Inhaled TMEM16A Potentiator GDC‐6988

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT The orally inhaled route of administration for respiratory indications can maximize drug exposure to the site of action (lung) to increase efficacy while minimizing systemic exposure to achieve an improved safety profile. However, due to the difficulty of taking samples from different regions of the human lung, often only systemic ...
Rui Zhu, Ian Sorrell, Fang Ma, Miaoran Ning, Yoen‐Ju Son, Gaohong She, Tom De Bruyn, Joshua Galanter, Nastya Kassir, Ryan Owen, Masoud Jamei, Iain Gardner, Yuan Chen   +12 more
wiley   +1 more source

Reproducibility of quantitative (R)-[11C]verapamil studies

EJNMMI Research, 2012
BackgroundP-glycoprotein [Pgp] dysfunction may be involved in neurodegenerative diseases, such as Alzheimer's disease, and in drug resistant epilepsy.
D. V. van Assema, M. Lubberink, R. Boellaard, R. Schuit, A. Windhorst, P. Scheltens, B. V. van Berckel, A. Lammertsma   +7 more
semanticscholar   +1 more source