Results 131 to 140 of about 80,362 (282)
LACK OF REVERSAL WITH VERAPAMIL OF DRUG RESISTANCE IN MULTIPLE MYELOMA [PDF]
, 1990 Brian G.M. Durie
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Pyroptosis in Peripheral Neuropathy: From Molecular Mechanisms to Therapeutic Targeting
CNS Neuroscience &Therapeutics, Volume 32, Issue 1, January 2026.Pyroptosis is a key inflammatory cell death pathway in peripheral neuropathy, with opposing roles: it perpetuates neuropathic pain but can be induced to kill neuroblastoma cells. This review consolidates mechanistic understanding and therapeutic strategies, arguing for a shift from disease‐centric to target‐centric treatment approaches to improve ...
Jinhuan Wei +11 more
wiley +1 more source
Dynamics of ABC Transporter P-glycoprotein in Three Conformational States. [PDF]
, 2019 We used hydrogen-deuterium exchange mass spectrometry (HDX-MS) to obtain a comprehensive view of transporter dynamics (85.8% sequence coverage) occurring throughout the multidrug efflux transporter P-glycoprotein (P-gp) in three distinct conformational ...
Chang, Geoffrey +2 more
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, 2017 In this work, we study degradation of clofibric acid (CFA) in aqueous solution using either ionizing radiation from a $^{60}$Co source or a non-thermal plasma produced by discharges in the air above the solution.
Ceriani, Elisa +7 more
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A Human Mass Balance and Metabolism Study of [14C]‐Ubrogepant in Healthy Male Adults
Clinical Pharmacology in Drug Development, Volume 15, Issue 1, January 2026.Abstract Ubrogepant is a calcitonin gene–related peptide receptor antagonist approved for the acute treatment of migraine with or without aura in adults. The mass balance and metabolism of ubrogepant was evaluated in six healthy male adults administered a single oral dose of [14C]‐ubrogepant 50 mg (∼200 µCi).
Ramesh R. Boinpally +13 more
wiley +1 more source
Clinical Pharmacology &Therapeutics, Volume 119, Issue 1, Page 198-207, January 2026.Antiangiogenic therapy with bevacizumab improves outcomes in ovarian cancer but induces hypertension, leading to major adverse cardiovascular events (MACE). While calcium channel blockers (CCBs) and angiotensin‐converting enzyme inhibitors (ACEi) are recommended for managing bevacizumab‐associated hypertension, their impacts on cancer progression and ...
Floriane Jochum +10 more
wiley +1 more source
VErapamil Plus Antiarrhythmic drugs Reduce Atrial Fibrillation recurrences after an electrical cardioversion (VEPARAF Study) [PDF]
, 2003 Antonio De Simone
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Repurposing Verapamil to Enhance Killing of T-ALL Cells by the mTOR Inhibitor Everolimus [PDF]
, 2023 Micol Silic‐Benussi +10 more
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Food Frontiers, Volume 7, Issue 1, January 2026.The presented review provides the potential antihypertensive benefits of traditionally employed edible seeds, presenting new perspectives and avenues for future research. ABSTRACT Hypertension, often referred to as a silent killer, is responsible for 7.5 million deaths, representing approximately 12.8% of all global mortality.
Jinmin Shi +8 more
wiley +1 more source
Activation of Extracellular-signal Regulated Kinase (ERK1/2) by Fluid Shear is Ca\u3csup\u3e2+\u3c/sup\u3e- and ATP-dependent in MC3T3-E1 Osteoblasts [PDF]
, 2008 To determine the role of Ca2+ signaling in activation of the Mitogen-Activated Protein Kinase (MAPK) pathway, we subjected MC3T3-E1 pre-osteoblastic cells to inhibitors of Ca2+ signaling during application of fluid shear stress (FSS).
Duncan, Randall L. +7 more
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