Results 91 to 100 of about 271,842 (268)

Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila

FEBS Letters, EarlyView.
Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia, Anna Dósa, Asha Kiran Maddali, András Jipa, Hajnalka Laczkó‐Dobos, Péter Lőw, Gábor Juhász   +6 more
wiley   +1 more source

Automatic Clock Domain Crossing Verification Flow For Dynamic Partial Reconfiguration

, 2018
Dynamic Partial Reconfiguration (DPR) on Field Programmable Gate Arrays (FPGAs) allows some of the logic to be configured while the rest of the logic keeps operating.
Ahmed Nader Mohieldin, Ahmed, Islam, Mostafa, Hassan, Mohieldin, Ahmed Nader, Hassan Mostafa, Islam Ahmed   +5 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Tools of risk management in product verification

, 2003
Thesis (S.M.)--Massachusetts Institute of Technology, Engineering Systems Division, Technology and Policy Program; and, (S.M.)--Massachusetts Institute of Technology, Dept. of Aeronautics and Astronautics, 2003.Includes bibliographical references (leaves
Zhang, Peng
core  

Modular Deductive Verification of Multiprocessor Hardware Designs

, 2019
We present a new framework for modular verification of hardware designs in the style of the Bluespec language. That is, we formalize the idea of components in a hardware design, with well-defined input and output channels; and we show how to specify and ...
Chlipala, Adam, Nirav, Dave, Arvind, Arvind, Vijayaraghavan, Muralidaran   +3 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Formal Verification based Security Verification in a System-On-Chip [PDF]

, 2023
This thesis deals with formal verification based security verification in a System-on-Chip. First, the absolute basics of functional verification, such as simulation and emulation, are presented.
Salminen, Niko
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

The correlation between uveal melanoma and iris nevus

Holistic Integrative Oncology
Purpose To investigate the impact of iris nevus on the incidence and prognosis of uveal melanoma (UM). Methods A retrospective cohort study was conducted involving 1128 UM cases and 4356 healthy controls. Participants were categorized based on iris nevus
Yuhang Yang, Jingting Luo, Zhaoxun Feng, Yang Li, Wenbin Wei, Yueming Liu   +5 more
doaj   +1 more source

Effect of different charge number metal ions on mechanical properties of carboxylated nitrile rubber composites

Hecheng xiangjiao gongye
Three types of metal oxide, magnesium oxide(MgO), zinc oxide(ZnO) and aluminium oxide(Al2O3), were added into carboxylated nitrile rubber (XNBR) to prepared XNBR/metal oxide composites, the properties of which, such as interactions between metal ions and
LUO Jiang1, XIE Qing-jun1, YANG Shu-yan2
doaj   +1 more source