Results 71 to 80 of about 271,842 (268)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Verification of correctness properties of programs that read input files

, 2019
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2019Cataloged from PDF version of thesis.Includes bibliographical references (pages 117-120).This thesis presents new techniques for ...
Kim, Deokhwan,Ph. D.Massachusetts Institute of Technology.
core  

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

INNOVATION TECHNOLOGY OF SUBCLINICAL ATHEROSCLEROSIS VERIFICATION

Наука и инновации в медицине, 2017
This review article presents duplex scanning of carotid arteries as a key and the most informative modern noninvasive innovation technology for diagnostics of subclinical atherosclerosis.
VV V Simerzin, OV V Fatenkov, IV V Gagloeva, MA A Galkina, ТЕ E Molchanova, YuR R Yunusova   +5 more
doaj   +1 more source

Development of a Three-Dimensional Optical Verification Technology without Environmental Pollution for Metal Components with Different Surface Properties. [PDF]

Materials (Basel), 2022
Kuo CC, He ZY, Lee CX.
europepmc   +1 more source

Practical Verification of Infinite Structures in agda2hs

, 2022
Agda allows for writing code that can be mathematically proven and verified to be correct, this type of languages is generally known as a proof assistant.
Schrijver, Remco (author)
core  

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Spatially resolved transcriptomics reveals gene expression characteristics in uveal melanoma

Holistic Integrative Oncology
Purpose Uveal melanoma (UM) is the most common intraocular malignancy in adults. Previous studies have examined the intra-tumoral heterogeneity. However, the spatial distribution of tumor cells within the tumor microenvironment and its relationship with ...
Jing-Ying Xiu, Yu-Ning Chen, Ya-Li Mao, Jing-Ting Luo, Hao-Wen Li, Yang Li, Wen-Bin Wei   +6 more
doaj   +1 more source

Molecular mechanism of Ganji Fang in the treatment of hepatocellular carcinoma based on network pharmacology, molecular docking and experimental verification technology. [PDF]

Front Pharmacol, 2023
Yang M, Yan Q, Luo Y, Wang B, Deng S, Luo H, Ye B, Wang X.   +7 more
europepmc   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source