Results 71 to 80 of about 12,029,480 (253)

Naïve Bayesian Models for Vero Cell Cytotoxicity

Pharmaceutical Research, 2018
To advance translational research of potential therapeutic small molecules against infectious microbes, the compounds must display a relative lack of mammalian cell cytotoxicity. Vero cell cytotoxicity (CC50) is a common initial assay for this metric. We explored the development of naïve Bayesian models that can enhance the probability of identifying ...
Alexander L. Perryman, Jimmy S. Patel, Riccardo Russo, Eric Singleton, Nancy Connell, Sean Ekins, Joel S. Freundlich   +6 more
openaire   +3 more sources

Real-time Imaging of Rabies Virus Entry into Living Vero cells

Scientific Reports, 2015
Understanding the mechanism of rabies virus (RABV) infection is vital for prevention and therapy of virulent rabies. However, the infection mechanism remains largely uncharacterized due to the limited methods and viral models.
Haijiao Xu, Xian Hao, Shaowen Wang, Zhiyong Wang, Mingjun Cai, Junguang Jiang, Q. Qin, Maolin Zhang, Hongda Wang   +8 more
semanticscholar   +1 more source

Marburg Virus Glycoprotein Is a Remarkable Virulent Factor Linked to Hemorrhagic Pathology: Evidence from Multimodal Experimental Systems

Advanced Science, EarlyView.
By integrating data from in vitro, ex vivo, and in vivo models, our research identifies the MARV glycoprotein as a remarkable hemorrhagic factor, filling a major gap in this important field. It also provides practical experimental tools for the basic research on viral pathogenesis and applied research aimed at antiviral intervention for hemorrhagic ...
Ting Yao, Hang Liu, Yanfeng Yao, Wei Deng, Jiawen Sun, Zhenyu Kang, Ashaq Ali, Chao Shan, Zhiming Yuan, Fei Deng, Hualin Wang, Yun‐Jia Ning   +11 more
wiley   +1 more source

Immunofluorescence microscopy of NheA on Vero cells.

, 2016
Staining of cell-bound NheA after treatment of Vero cells with B. cereus supernatants. (A) MHI 1507 NheB (100 ng ml-1 and approx. 10 ng ml-1 NheC) with mAb 1G4 neutralized NheA untreated Vero cells stained with primary and secondary antibody.
E. Märtlbauer (3235083), R. Dietrich (3235086), A. Didier (3235080)   +2 more
core   +1 more source

Adaptation of Vero cells to chemically-defined suspension culture and implementation of a stirred tank reactor process for the production of oncolytic measles virus

Vaccine: X
Oncolytic measles virus (MeV) naturally targets cancer cells, inducing their lysis and stimulating anti-tumor immune responses. The high titers of infectious MeV for treatment (107–109 TCID₅₀ per dose) are currently produced in adherent Vero cells ...
Dustin Eckhardt, Jan-P. Klee, Irakli Sardlishvili, Jana Mueller, Lars E. Walter, Stefanie Fey, Jan Thorbow, Tim Hofmann, Aline Zimmer, Peter Czermak, Denise Salzig   +10 more
doaj   +1 more source

Suscetibilidade da linhagem de células Vero a cepas vacinais do vírus do sarampo Susceptibility of Vero cell line to vaccine strains of the measles virus

Revista de Saúde Pública, 1994
A suscetibilidade da linhagem de células Vero ao vírus do sarampo é bem conhecida e sua utilização no controle da potência da vacina contra o sarampo é amplamente difundida.
Célia Sayoko Takata, Flávia Saldanha Kubrusly, Cosue Miyaki, Inácio França Mendes, Edda de Rizzo   +4 more
doaj   +1 more source

Dengue-3 Virus Entry into Vero Cells: Role of Clathrin-Mediated Endocytosis in the Outcome of Infection

PLoS ONE, 2015
The endocytic uptake and intracellular trafficking for penetration of DENV-3 strain H-87 into Vero cells was analyzed by using several biochemical inhibitors and dominant negative mutants of cellular proteins.
Luana E. Piccini, V. Castilla, E. Damonte   +2 more
semanticscholar   +1 more source

UCHL3 Regulates Subgenomic Flaviviral RNA Condensates to Promote Virus Propagation

Advanced Science, EarlyView.
ABSTRACT Flavivirus subgenomic RNAs (sfRNAs) antagonise antiviral defences, yet how sfRNAs are organized and maintained in cells remains poorly understood. Here we identify ubiquitin C‐terminal hydrolase L3 (UCHL3) as a post‐translational regulator of flavivirus sfRNA stability and function.
Oscar Trejo‐Cerro, Anna Beekmayer‐Dhillon, Qi Wen Teo, Lewis Siu, Ming Yuan Li, Kate J. Heesom, Adán Pinto‐Fernández, Sumana Sanyal   +7 more
wiley   +1 more source

Preparation and evaluation of a novel, live, attenuated influenza H1N1 vaccine strain produced by a modified classical reassortment method

Human Vaccines & Immunotherapeutics, 2018
Live attenuated influenza vaccine (LAIV)-based Vero cells could provide a better choice to control and prevent influenza virus infections. This study used the human influenza virus A/Yunnan/1/2005Vca(H3N2) (YN/05Vca) as a donor strain.
Yunfeng Long, Lei Ma, Ze Liu, Shaohui Song, Xingliang Geng, Fan Yang, Qi Guo, Zhuofan Li, Weidong Li, Guoyang Liao   +9 more
doaj   +1 more source

Mycoplasma detection in a mouse cell line and possible contamination source

Revista Peruana de Biología, 2014
The detection of contaminating mycoplasma in a NS-1 myeloma celI line was studied comparing three methods The probable source of mycoplasma contamination were some batches of commercial sera Fetal Bovine Sera (FBS) mouse myeloma NS-1 cells and Vero ...
Willian Cornejo M., Libertad Alzamora G.
doaj   +1 more source