Results 81 to 90 of about 12,029,480 (253)

Rational Design of Broad‐Spectrum Anti‐Enteroviral Molecular Glues Targeting Enteroviral RNAi Suppressors

Advanced Science, EarlyView.
By leveraging this homodimerization mechanism, molecular glues were rationally designed to induce dysfunctional 3A dimerization, thereby restoring antiviral RNAi. The optimal molecular glue, VTP‐32, demonstrated potent and pan‐enterovirus (groups A, B, D) antiviral effects.
Yuan Fang, Xiong Xie, Huidi Fan, Botao Wu, An Wang, Wenhao Dai, Zezhong Liu, Jian Li, Huoyan Tong, Jianan Li, Yujie Ren, Jinlin Wang, Xi Zhou, Hong Liu   +13 more
wiley   +1 more source

KDM6A regulates ACE2 and DPP4 in Vero E6 cells.

, 2023
(A) Volcano plot for RNA sequencing of control and KDM6A polyclonal KO Vero E6 cells. The x axis shows log2 fold change and the y axis shows -log10 of the adjusted P value (adj.P) as calculated by DESeq2.
Scott B. Biering (7165010), Qin Yan (281622), Jin Wei (424761), Sylvia A. Sarnik (16502840), Wesley L. Cai (5597987), Bridget L. Menasche (16502843), Robert C. Orchard (8677401), Mia Madel Alfajaro (10319201), Renata B. Filler (8677386), Sonam Patel (14909265), Craig B. Wilen (8677404), Silvana Konermann (9683935), Susan R. Compton (11747702), Patrick D. Hsu (16324564), Madison S. Strine (8677383), Vincent R. Graziano (8677380)   +15 more
core   +1 more source

Electrospun Poly (ε-Caprolactone) Nanofiber Mat as Extracellular Matrix [PDF]

Cell Journal, 2008
Objective: Investigation of the suitability of electrospun Poly (ε-caprolactone) (PCL)nanofiber scaffold for the Vero cell culture.Materials and Methods: Electrospinning was used for production of PCL nanofibersscaffolds.
Laleh Ghasemi-Mobarakeh, Mohammad Morshed,, Khadije Karbalaie, Mehrafarin Fesharaki, Mohammad Hossein Nasr-Esfahani, Hossein Baharvand   +5 more
doaj  

Dengue type 4 live-attenuated vaccine viruses passaged in vero cells affect genetic stability and dengue-induced hemorrhaging in mice. [PDF]

PLoS ONE, 2011
Most live-attenuated tetravalent dengue virus vaccines in current clinical trials are produced from Vero cells. In a previous study we demonstrated that an infectious cDNA clone-derived dengue type 4 (DEN-4) virus retains higher genetic stability in MRC ...
Hsiang-Chi Lee, Yu-Ting Yen, Wen-Yu Chen, Betty A Wu-Hsieh, Suh-Chin Wu   +4 more
doaj   +1 more source

Production of Toxoplasma gondii in Vero Cell Culture

Turkish Journal of Parasitology, 2011
To investigate parasite-host dynamics in cultures of Toxoplasma gondii (T. gondii).T. gondii tachyzoites were incubated in Vero-E6 cell cultures at 37°C, 5％CO₂. Tachyzoites and host cells were characterized by light microscopy. Growth kinetics of the parasite were determined.Doubling time of tachyzoites and viability of host cells were determined by ...
Gizem, Sivrikaya, Emin Ümit, Bağrıaçık   +1 more
openaire   +2 more sources

ZDHHC18‐Mediated Palmitoylation of ORF3a Promotes SARS‐CoV‐2 Pathogenesis by Antagonizing TRIM16‐Mediated Ubiquitination and Proteasomal Degradation

Advanced Science, EarlyView.
Palmitoylation by ZDHHC18 blocks ORF3a K27‐linked ubiquitination mediated by TRIM16, thereby preventing its proteasomal degradation and strengthening viral pathogenesis. Targeting palmitoylation through a pharmacological inhibitor (2‐BP), a competitive inhibitory peptide (OPIP), or adenovirus‐mediated knockdown of ZDHHC18 expression presents a ...
Sidi Yang, Kun Li, Lihong Liu, Linsen Zeng, Qifeng Deng, Jiacheng Huang, Xiaoran Dong, Xin Wang, Jianwei Liang, Hongchao Liu, Hong Peng, Yuxin Lin, Xiaolu Xie, Yuzhen Ye, Tiefeng Xu, Zhaohuan Wang, Chun‐Mei Li, Deyin Guo   +17 more
wiley   +1 more source

Expression of Gn/Gc in Vero-G cells.

, 2014
(A) Vero E6 cells were infected with MP-12 at an MOI of 1 and cell extracts were prepared at 12 h p.i. (MP-12). The same amounts of cell extracts were prepared from Vero-G cells (Vero-G).
Shinji Makino (19911), John C. Morrill (250938), Shin Murakami (241776), Kaori Terasaki (250950), Sydney I. Ramirez (540018)   +4 more
core   +1 more source

Clathrin- and serine proteases-dependent uptake of porcine epidemic diarrhea virus into Vero cells

Virus Research, 2014
Highlights • PEDV enters Vero cells via clathrin-mediated endocytosis.• PEDV entry in Vero cells is low pH sensitive.• PEDV requires serine proteolysis during entry.
Jung-Eun Park, D. J. Cruz, Hyun-Jin Shin
semanticscholar   +1 more source

A Humanized Anti‐gD Broadly Neutralizing Antibody Confers Complete Post‐Exposure Protection against Pseudorabies Virus

Advanced Science, EarlyView.
Pseudorabies virus (PRV), an emerging zoonotic α‐herpesvirus, causes life‐threatening human encephalitis. We identified a broad‐spectrum neutralizing antibody 6F7 targeting PRV gD. It blocks gD‐Nectin‐1 binding and membrane fusion, inhibiting replication across all PRV variants, representing a promising candidate for anti‐PRV therapy.
Yue Sun, Jianbo Liu, Shi‐Jia Xu, Meng‐Xin Wang, Hongliang Zhang, Yanhe Zhang, Zhi‐Jun Tian, Jin‐Mei Peng, Xin Yin, Tong‐Qing An, Xue‐Hui Cai, Yan‐Dong Tang   +11 more
wiley   +1 more source

Parainfluenza virus 5 genomes are located in viral cytoplasmic bodies whilst the virus dismantles the interferon-induced antiviral state of cells

, 2009
This work was supported by the Wellcome Trust.Although the replication cycle of parainfluenza virus type 5 (PIV5) is initially severely impaired in cells in an interferon (IFN)-induced antiviral state, the virus still targets STAT1 for degradation.
Carlos, T S, Schneider, M, Simas, J P, Randall, Richard Edward, Young, Dan Frushard   +4 more
core   +1 more source